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Ranolazine dihydrochloride
🥰Excellent
Catalog No. T0207Cas No. 95635-56-6
Alias RS 43285, Ranolazine 2HCl
Ranolazine dihydrochloride (Ranolazine 2HCl) , an antianginal agent, can treat arrhythmia via a novel mechanism of action (inhibition of the late phase of the inward sodium current), and do not affect blood pressure or heart rate.
Ranolazine dihydrochloride
🥰Excellent
Purity: 100%
Catalog No. T0207Alias RS 43285, Ranolazine 2HClCas No. 95635-56-6
Ranolazine dihydrochloride (Ranolazine 2HCl) , an antianginal agent, can treat arrhythmia via a novel mechanism of action (inhibition of the late phase of the inward sodium current), and do not affect blood pressure or heart rate.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 mg | $44 | In Stock | |
| 100 mg | $62 | In Stock | |
| 200 mg | $97 | In Stock | |
| 500 mg | $158 | In Stock | |
| 1 g | $217 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $63 | In Stock |
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Purity:100%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Ranolazine dihydrochloride (Ranolazine 2HCl) , an antianginal agent, can treat arrhythmia via a novel mechanism of action (inhibition of the late phase of the inward sodium current), and do not affect blood pressure or heart rate. |
| Targets&IC50 | IKr:12 μM (IC50), INa:6 μM (IC50) |
| In vitro | Ranolazine (5 mM and 10 mM) reversibly shortened the duration of twitch contractions and abolished postcontractions.Ranolazine bound more to sodium channels in the inactivated state. In cardiomyocytes, selective inhibition of late I (sodium) by Ranolazine reduced sodium-dependent calcium overload and attenuated ventricular repolarization and contraction, which correlated with abnormalities in heart failure and ischemia/reperfusion injury. In dog left ventricular myocytes, in a concentration-dependent manner Ranolazine was able to reversibly shorten myocyte action potential duration in response to 0.25/0.5 Hz stimulation. |
| In vivo | Ranolazine (5 mM and 10 mM) reversibly shortened the duration of twitch contractions and abolished postcontractions.Ranolazine bound more to sodium channels in the inactivated state. In cardiomyocytes, selective inhibition of late I (sodium) by Ranolazine reduced sodium-dependent calcium overload and attenuated ventricular repolarization and contraction, which correlated with abnormalities in heart failure and ischemia/reperfusion injury. In dog left ventricular myocytes, in a concentration-dependent manner Ranolazine was able to reversibly shorten myocyte action potential duration in response to 0.25/0.5 Hz stimulation. |
| Alias | RS 43285, Ranolazine 2HCl |
| Molecular Weight | 500.46 |
| Formula | C24H35Cl2N3O4 |
| Cas No. | 95635-56-6 |
| Smiles | Cl.Cl.COc1ccccc1OCC(O)CN1CCN(CC(=O)Nc2c(C)cccc2C)CC1 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 45 mg/mL (89.92 mM)  H2O: 50.1 mg/mL (100 mM) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
DMSO/H2O
H2O
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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