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Rocuronium bromide (ORG 9426) is a muscle relaxant or aminosteroid non-depolarizing neuromuscular blocker. During surgery or mechanical ventilation, it is used to facilitate endotracheal intubation and to provide skeletal muscle relaxation.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
10 mg | $45 | In Stock | |
50 mg | $61 | In Stock | |
100 mg | $81 | In Stock | |
200 mg | $105 | In Stock | |
500 mg | $142 | In Stock | |
1 mL x 10 mM (in DMSO) | $50 | In Stock |
Description | Rocuronium bromide (ORG 9426) is a muscle relaxant or aminosteroid non-depolarizing neuromuscular blocker. During surgery or mechanical ventilation, it is used to facilitate endotracheal intubation and to provide skeletal muscle relaxation. |
In vitro | Rocuronium effectively reduces indirectly elicited twitch tensions in both normal diaphragms (IC50: 9.84 μM) and those pretreated, showing a significant decrease (P < .01, n = 6) in a concentration-dependent manner [1]. It exhibits a similar ED95 for both children and adults, with a duration of action comparable to vecuronium but is shorter in children. Conventional doses of cholinesterase inhibitors can readily reverse its effects [2]. The onset time for maximum block is 1.7 (32) minutes, with the duration until 25% recovery of twitch height at 53 (19) minutes, and recovery from 25% to 75% of twitch height taking 20 (37) minutes [3]. |
Alias | ORG 9426 (Bromide), ORG 9426 |
Molecular Weight | 609.68 |
Formula | C32H53BrN2O4 |
Cas No. | 119302-91-9 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 113 mg/mL (185.3 mM) H2O: 112 mg/mL (183.7 mM) Ethanol: 113 mg/mL (185.3 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O/DMSO/Ethanol
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