Shopping Cart
- Remove All
Your shopping cart is currently empty
suvn-911
🥰Excellent
Catalog No. T9787Cas No. 2414674-71-6
suvn-911 is a potent and selective antagonist of neuronal nicotinic acetylcholine α4β2 receptor (Ki = 1.5 nM) with antidepressant activity.
suvn-911
🥰Excellent
Purity: 98.88%
Catalog No. T9787Cas No. 2414674-71-6
suvn-911 is a potent and selective antagonist of neuronal nicotinic acetylcholine α4β2 receptor (Ki = 1.5 nM) with antidepressant activity.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $65 | In Stock | |
| 5 mg | $143 | In Stock | |
| 10 mg | $227 | In Stock | |
| 25 mg | $377 | In Stock | |
| 50 mg | $536 | In Stock | |
| 100 mg | $732 | In Stock | |
| 200 mg | $986 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $191 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "suvn-911"
Adiphenine hydrochloride
Spasnil, Sentiv, Patrovina, Adiphenine HCl
T007250-42-0
Adiphenine hydrochloride (Patrovina), a nicotinic receptor inhibitor, can be used as an antispasmodic drug.
- $39
Size
QTY
D-Menthol
Menthol, (+)-MENTHOL
TN154415356-60-2
D-Menthol ((+)-MENTHOL) is a common compound in pharmaceutical and commercial products and a popular additive to cigarettes, it attenuates α±7 mediated Ca 2+ transients in the cell body and neurite, suggests that menthol inhibits α±7-nACh receptors in a noncompetitive manner.
- $39
Size
QTY
Ribavirin
Cited
Tribavirin, RTCA, NSC-163039, ICN-1229
T068436791-04-5
Ribavirin (Tribavirin) is a synthetic nucleoside analog of ribofuranose with activity against hepatitis C virus and other RNA viruses.
- $39
Size
QTY
CitedCholine chloride
Hepacholine, Biocoline, Biocolina
T103967-48-1
Choline chloride (Biocoline) is a basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism.
- $33
Size
QTY
Propoxur
Propoxure, Baygon, Aprocarb
T0976114-26-1
Propoxur (Propoxure) is an insecticide used to control cockroaches, flies, mosquitoes, and lawn and turf insects. Acute (short-term) exposure of humans to propoxur by ingestion leads to cholinesterase inhibition of red blood cells, with mild cholinergic symptoms including blurred vision, nausea, vomiting, sweating, and tachycardia; however, the effects are transient. Chronic (long-term) inhalation exposure has resulted in depressed cholinesterase levels, headaches, vomiting, and nausea in humans. Chronic ingestion studies in animals have reported depressed cholinesterase levels, depressed body weight, effects to the liver and bladder, and a slight increase in neuropathy. No information is available on the reproductive, developmental, or carcinogenic effects of propoxur in humans. Mixed results are available from cancer studies of propoxur in animals. EPA has not classified propoxur for carcinogenicity.
- $29
Size
QTY
Nanofin
Naniopinum, Lupetidine, Lupetidin, 2,6-Lupetidine, 2,6-Dimethylpiperidine
T1007504-03-0
Nanofin (Lupetidine) is a neuropathic blocker, with antihypertensive effect.
- $31
Size
QTY
Clozapine N-Oxide
Cited
T449434233-69-7
Clozapine N-oxide is the major metabolite of Clozapine and is blood-brain barrier permeable. Clozapine N-oxide is an agonist of DREADDs and activates the DREADD receptors hM3Dq and hM4Di. Clozapine N-oxide is also a dopamine antagonist and selective muscarinic M4 receptor agonist.
- $30
Size
QTY
CitedPilocarpine nitrate Cited
Pilofrin, Pilagan
T1231148-72-1
Pilocarpine nitrate (Pilagan) is a slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
- $41
Size
QTY
CitedForskolin Cited
FSK, Colforsin, Coleonol
T293966575-29-9
Forskolin (Coleonol) is a natural product, an adenylate cyclase activator (EC50=0.5 μM). Forskolin increases cAMP levels, activates PXR and FXR, and induces autophagy. Forskolin produces positive inotropic effects in the heart, and has platelet anticoagulant and antihypertensive effects.
- $36
Size
QTY
CitedAmitriptyline hydrochloride
Tryptizol, Domical, Annoyltin, Amitriptyline HCl
T0678549-18-8
Amitriptyline hydrochloride (Annoyltin) is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptive activities.
5-HT ReceptorAChRAdrenergic ReceptorHistamine ReceptorNorepinephrineSerotonin TransporterSigma receptorSodium ChannelTrk receptor
- $45
Size
QTY
Pilocarpine Hydrochloride Cited
Pilocarpine HCl, NSC 5746 HCl, (+)-Pilocarpine hydrochloride
T080454-71-7
Pilocarpine Hydrochloride (NSC 5746 HCl) , a nonselective muscarinic acetylcholine receptor agonist, is utilized to produce an experimental model of epilepsy.
- $54
Size
QTY
Cited(+)-Sparteine
Pachycarpine
T7853492-08-0
(+)-Sparteine is a quinoline alkaloid extracted from Scotch broom, a sodium channel blocker and a class 1a antiarrhythmic agent. It competitively inhibits the activity of nicotinic acetylcholine receptors in nerve cells and is a ganglionic blocking agent.
- $42
Size
QTY
Select Batch
Purity:98.88%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | suvn-911 is a potent and selective antagonist of neuronal nicotinic acetylcholine α4β2 receptor (Ki = 1.5 nM) with antidepressant activity. |
| Targets&IC50 | α4β2 nAChR:1.5 nM(Ki) |
| In vitro | SUVN-911 demonstrates high selectivity towards α4β2 over α3β4 nACh receptors, standing out against a broad spectrum of over 70 targets, including GPCRs, ion channels, enzymes, peptides, steroids, second messengers, growth factors, and prostaglandins. This specificity underscores its promising potential in targeted pharmacological applications. |
| In vivo | In male Wistar rats, suvn-911 (1.0-10.0 mg/kg; p.o.) showed significant antidepressant-like activity with no signs of tachyphylaxis. suvn-911 (3 mg/kg; p.o.) showed high oral exposures, longer half-lives(T1/2 = 3.34 hr), and adequate brain penetration in Wistar rats. suvn-911 showed metabolic stability and no cardiovascular and gastrointestinal side effects[1]. |
| Molecular Weight | 261.15 |
| Formula | C11H14Cl2N2O |
| Cas No. | 2414674-71-6 |
| Smiles | Cl.Clc1ccc(OC[C@@H]2C[C@H]3C[C@H]3N2)cn1 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50.00 mg/mL (191.46 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
| ||||||||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy suvn-911 | purchase suvn-911 | suvn-911 cost | order suvn-911 | suvn-911 chemical structure | suvn-911 in vivo | suvn-911 in vitro | suvn-911 formula | suvn-911 molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.