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suvn-911

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COA HPLC HNMR

suvn-911

Catalog No. T9787Cas No. 2414674-71-6

suvn-911 is a potent and selective antagonist of neuronal nicotinic acetylcholine α4β2 receptor (Ki = 1.5 nM) with antidepressant activity.

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Pack Size	Price	Availability
1 mg	$108	In Stock
5 mg	$239	In Stock
10 mg	$378	In Stock
25 mg	$629	In Stock
50 mg	$893	In Stock
100 mg	$1,220	In Stock
1 mL x 10 mM (in DMSO)	$318	In Stock

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Product Introduction

Bioactivity

Description	suvn-911 is a potent and selective antagonist of neuronal nicotinic acetylcholine α4β2 receptor (Ki = 1.5 nM) with antidepressant activity.
In vitro	SUVN-911 demonstrates high selectivity towards α4β2 over α3β4 nACh receptors, standing out against a broad spectrum of over 70 targets, including GPCRs, ion channels, enzymes, peptides, steroids, second messengers, growth factors, and prostaglandins. This specificity underscores its promising potential in targeted pharmacological applications.
In vivo	In male Wistar rats, suvn-911 (1.0-10.0 mg/kg; p.o.) showed significant antidepressant-like activity with no signs of tachyphylaxis. suvn-911 (3 mg/kg; p.o.) showed high oral exposures, longer half-lives(T1/2 = 3.34 hr), and adequate brain penetration in Wistar rats. suvn-911 showed metabolic stability and no cardiovascular and gastrointestinal side effects[1].

Chemical Properties

Molecular Weight	224.69
Formula	C11H13ClN2O
Cas No.	2414674-71-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (222.53 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.4506 mL	22.2529 mL	44.5058 mL	222.5288 mL
5 mM	0.8901 mL	4.4506 mL	8.9012 mL	44.5058 mL
10 mM	0.4451 mL	2.2253 mL	4.4506 mL	22.2529 mL
20 mM	0.2225 mL	1.1126 mL	2.2253 mL	11.1264 mL
50 mM	0.0890 mL	0.4451 mL	0.8901 mL	4.4506 mL
100 mM	0.0445 mL	0.2225 mL	0.4451 mL	2.2253 mL

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In Vivo Formulation Calculator (Clear solution)

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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