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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $82 | In Stock | |
10 mg | $127 | In Stock | |
25 mg | $246 | In Stock | |
50 mg | $317 | In Stock | |
200 mg | $694 | In Stock | |
1 mL x 10 mM (in DMSO) | $88 | In Stock |
Description | Volinanserin (MDL100907) (MDL 100907) is a potent and selective antagonist of the serotonin receptor 5-HT2 (Ki: 0.36 nM) and shows 300-fold selectivity for 5-HT2 receptor over 5-HT1c, alpha-1 adrenergic and sigma receptors. |
Targets&IC50 | 5-HT2 receptor:0.36 nM (Ki) |
In vitro | Volinanserindemonstrated low nanomolar or subnanomolar binding in vitro at the 5-HT2A receptor and showed a > 100-fold separation from all other receptors measured. Volinanserinhad subnanomolar potency as a 5-HT2A antagonist in vitro in reversing 5-HT-stimulated inositol phosphate accumulation in NIH 3T3 cells transfected with the rat 5-HT2A receptor [2]. |
In vivo | In mice, Volinanserinblocked amphetamine-stimulated locomotion at doses that did not significantly affect apomorphine-stimulated climbing behavior. When administered chronically, Volinanserinselectively reduced the number of spontaneously active A10 neurons [1]. In vivo, Volinanserinpotently inhibited 5-methoxy-N, N-dimethyltryptamine-induced head twitches in mice or 5-hydroxytryptophan-induced head twitches in rats. In vivo, functional tests in mice revealed a > 500-fold separation between doses that produced 5-HT2A antagonism and doses that produced alpha 1-adrenergic or striatal D2 antagonism [2]. |
Alias | M 100907, MDL100907 |
Molecular Weight | 373.46 |
Formula | C22H28FNO3 |
Cas No. | 139290-65-6 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 100 mg/mL (267.8 mM) Ethanol: 18 mg/mL (48.2 mM) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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