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Pack Size | Price | Availability | Quantity |
---|---|---|---|
100 mg | $49 | In Stock |
Description | 5-Benzyloxygramine is a N protein PPI orthosteric stabilizer that exhibits both antiviral and N-NTD protein-stabilizing activities[1]. 5-benzyloxygramine stabilizes the N-NTD dimers through simultaneous hydrophobic interactions with both partners, resulting in abnormal N protein oligomerization that was further confirmed in the cell[1]. [1]. Shan-Meng Lin, et al. Structure-Based Stabilization of Non-native Protein-Protein Interactions of Coronavirus Nucleocapsid Proteins in Antiviral Drug Design. J Med Chem. 2020 Mar 26;63(6):3131-3141. |
In vitro | 5-Benzyloxygramine induces stabilization of N-NTD dimers via concurrent hydrophobic interactions with both entities, leading to irregular N protein oligomerization, a finding further substantiated in cellular studies[1]. |
Molecular Weight | 280.36 |
Formula | C18H20N2O |
Cas No. | 1453-97-0 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 250 mg/mL (891.71 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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