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Brilaroxazine

🥰Excellent
Catalog No. T14782Cas No. 1239729-06-6
Alias RP5063

Brilaroxazine (RP5063) is a potent multimodal dopamine/5-HT modulator. Brilaroxazine is a partial agonist of dopamine D2, D3, and D4 receptors, 5-HT1A (Ki =1.5 nM) and 5-HT2A (Ki = 2.5 nM), and has antagonist activity 5-HT2B, and 5-HT7 receptors with Kis of 0.19 nM and 2.7 nM, respectively. Brilaroxazine can be used for research about cognitive impairments in neuropsychiatric and neurological diseases.

Brilaroxazine

Brilaroxazine

🥰Excellent
Purity: 98.00%
Catalog No. T14782Alias RP5063Cas No. 1239729-06-6
Brilaroxazine (RP5063) is a potent multimodal dopamine/5-HT modulator. Brilaroxazine is a partial agonist of dopamine D2, D3, and D4 receptors, 5-HT1A (Ki =1.5 nM) and 5-HT2A (Ki = 2.5 nM), and has antagonist activity 5-HT2B, and 5-HT7 receptors with Kis of 0.19 nM and 2.7 nM, respectively. Brilaroxazine can be used for research about cognitive impairments in neuropsychiatric and neurological diseases.
Pack SizePriceAvailabilityQuantity
1 mg$107In Stock
5 mg$263In Stock
10 mg$428In Stock
25 mg$737In Stock
50 mg$1,060In Stock
100 mg$1,450In Stock
500 mg$2,880In Stock
1 mL x 10 mM (in DMSO)$387In Stock
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Purity:98.00%
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Product Introduction

Bioactivity
Description
Brilaroxazine (RP5063) is a potent multimodal dopamine/5-HT modulator. Brilaroxazine is a partial agonist of dopamine D2, D3, and D4 receptors, 5-HT1A (Ki =1.5 nM) and 5-HT2A (Ki = 2.5 nM), and has antagonist activity 5-HT2B, and 5-HT7 receptors with Kis of 0.19 nM and 2.7 nM, respectively. Brilaroxazine can be used for research about cognitive impairments in neuropsychiatric and neurological diseases.
Targets&IC50
5-HT2B receptor:0.19 nM (Ki), 5-HT2A receptor:2.5 nM (Ki), 5-HT7 receptor:2.7 nM (Ki), 5-HT1A receptor:1.5 nM (Ki)
In vivo
Brilaroxazine (10 mg/kg) had efficacy in PAH, and mitigated the functional and structural effects of MCT-induced PAH, with significant improvements in pulmonary hemodynamics, right ventricular (RV) hypertrophy, SO2, and pulmonary blood vessel structural changes[3].
AliasRP5063
Chemical Properties
Molecular Weight450.36
FormulaC22H25Cl2N3O3
Cas No.1239729-06-6
SmilesClc1cccc(N2CCN(CCCCOc3ccc4OCC(=O)Nc4c3)CC2)c1Cl
Relative Density.1.301 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 95 mg/mL (210.94 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2204 mL11.1022 mL22.2045 mL111.0223 mL
5 mM0.4441 mL2.2204 mL4.4409 mL22.2045 mL
10 mM0.2220 mL1.1102 mL2.2204 mL11.1022 mL
20 mM0.1110 mL0.5551 mL1.1102 mL5.5511 mL
50 mM0.0444 mL0.2220 mL0.4441 mL2.2204 mL
100 mM0.0222 mL0.1110 mL0.2220 mL1.1102 mL

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