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Fedratinib hydrochloride hydrate

Catalog No. T9251 CAS 1374744-69-0

Synonyms: TG-101348 hydrochloride hydrate, SAR 302503 hydrochloride hydrate

Fedratinib hydrochloride hydrate (SAR 302503 hydrochloride hydrate) is a potent, selective, ATP-competitive and orally active JAK2 inhibitor.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Fedratinib hydrochloride hydrate Chemical Structure

Fedratinib hydrochloride hydrate, CAS 1374744-69-0

Pack Size	Availability	Price/USD
5 mg	In stock	$ 39.00
10 mg	In stock	$ 55.00
25 mg	In stock	$ 78.00
50 mg	In stock	$ 102.00
100 mg	In stock	$ 122.00
200 mg	In stock	$ 197.00
1 mL * 10 mM (in DMSO)	In stock	$ 61.00

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Purity: 98.96%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Fedratinib hydrochloride hydrate (SAR 302503 hydrochloride hydrate) is a potent, selective, ATP-competitive and orally active JAK2 inhibitor.
Targets&IC50	JAK2:3 nM, FLT3:15 nM, RET:48 nM, JAK2 (V617F):3 nM

Synonyms	TG-101348 hydrochloride hydrate, SAR 302503 hydrochloride hydrate
Molecular Weight	615.61
Formula	C27H40Cl2N6O4S
CAS No.	1374744-69-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 120 mg/mL (194.92 mM), Sonification is recommended.

H2O: 97 mg/mL (157.56 mM), Sonification is recommended.

References and Literature

1. Wernig G, et al. Efficacy of TG101348, a selective JAK2 inhibitor, in treatment of a murine model of JAK2V617F-induced polycythemia vera. Cancer Cell. 2008 Apr;13(4):311-20. 2. Geron I, et al. Selective inhibition of JAK2-driven erythroid differentiation of polycythemia vera progenitors. Cancer Cell. 2008 Apr;13(4):321-30.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library EMA Approved Drug Library Anti-Cancer Approved Drug Library Anti-Cancer Drug Library Drug Repurposing Compound Library Approved Drug Library FDA-Approved Kinase Inhibitor Library NO PAINS Compound Library FDA-Approved Drug Library Reprogramming Compound Library

Related Products

Related compounds with same targets

Amentoflavone CPTH2 Oleuropein PF-543 hydrochloride Antiproliferative agent-27 DC_AC50 Dextran sulfate sodium salt (MW 4500-5500) Lidocaine

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Fedratinib hydrochloride hydrate 1374744-69-0 Angiogenesis Apoptosis Chromatin/Epigenetic JAK/STAT signaling Stem Cells JAK STAT5 JAK2V617F myeloproliferative TG-101348 hydrochloride Janus kinase phosphorylation anti-proliferation TG-101348 hydrochloride hydrate FLT3 inhibit TG-101348 hydrochloride Hydrate RET SAR 302503 hydrochloride hydrate orally Fedratinib hydrochloride Hydrate SAR 302503 hydrochloride anti-cancer SAR 302503 hydrochloride Hydrate JAK2 Inhibitor Fedratinib hydrochloride inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.