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L-Ascorbic acid

Catalog No. T0928 CAS 50-81-7

Synonyms: Vitamin C, Ascorbic acid, L(+)-Ascorbic acid, L-Ascorbate

L-Ascorbic acid (Vitamin C) is a natural product that is a potent reducing agent and antioxidant. L-Ascorbic acid functions in fighting bacterial infections, in detoxifying reactions, and in the formation of collagen. L-Ascorbic acid is used in the treatment of scurvy.

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L-Ascorbic acid, CAS 50-81-7

Pack Size	Availability	Price/USD	Quantity
1 g	In stock	$ 42.00
1 mL * 10 mM (in DMSO)	In stock	$ 30.00

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Purity: 99.89%

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Description	L-Ascorbic acid (Vitamin C) is a natural product that is a potent reducing agent and antioxidant. L-Ascorbic acid functions in fighting bacterial infections, in detoxifying reactions, and in the formation of collagen. L-Ascorbic acid is used in the treatment of scurvy.
In vitro	METHODS: Human osteosarcoma cells MG-63 were treated with L-Ascorbic acid (62.5-1000 µM) for 3-24 h. Cell viability was measured by XTT Assay. RESULTS: Cell viability was consistently >95% when cells were treated with L-Ascorbic acid at concentrations of 0-250 µM. When higher concentrations were used, a dose-dependent decrease in cell viability was observed. [1] METHODS: Melanoma cells WM1366 were treated with L-Ascorbic acid (5-50 µM) for 24 h. The expression levels of target proteins were measured using Western Blot. RESULTS: The lowest concentration of L-Ascorbic acid (5 µM) significantly reduced the normoxic expression of HIF-1α protein in human melanoma cell lines. [2]
In vivo	METHODS: L-Ascorbic acid (1-4.5 g/kg) was administered intraperitoneally to irradiated C57BL/6 mice to detect radioprotective activity. RESULTS: Administration of 3 g/kg L-Ascorbic acid immediately after exposure significantly increased the survival rate of mice after 7-8 Gy WBI. However, administration of less than 3 g/kg L-Ascorbic acid was ineffective, and 4 g/kg and above was harmful to mice. [3] METHODS: To investigate the effects on amnesia, L-Ascorbic acid (60-160 mg/kg) was administered intraperitoneally to diazepam, scopolamine, and aging-induced amnesic Swiss mice once daily for 3-8 days. RESULTS: L-Ascorbic acid improved learning and memory in aging mice, as evidenced by decreased transfer latency and increased descending latency. [4]

Synonyms	Vitamin C, Ascorbic acid, L(+)-Ascorbic acid, L-Ascorbate
Molecular Weight	176.12
Formula	C6H8O6
CAS No.	50-81-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 35.7mg/ml（202.8mM)

DMSO: 33 mg/mL (187.4 mM)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. Valenti MT, et al. Ascorbic acid induces either differentiation or apoptosis in MG-63 osteosarcoma lineage. Anticancer Res. 2014 Apr;34(4):1617-27. 2. Miles SL, et al. Ascorbic acid and ascorbate-2-phosphate decrease HIF activity and malignant properties of human melanoma cells. BMC Cancer. 2015 Nov 7;15:867. 3. Sato T, et al. Treatment of irradiated mice with high-dose ascorbic acid reduced lethality. PLoS One. 2015 Feb 4;10(2):e0117020. 4. Parle M, et al. Ascorbic Acid: a promising memory-enhancer in mice. J Pharmacol Sci. 2003 Oct;93(2):129-35. 5. Kida T, et al. Exp Eye Res, 2010, 91(1), 85-91. 6. Wang S, Li F, Qiao R, et al. Arginine-Rich Manganese Silicate Nanobubbles as a Ferroptosis-Inducing Agent for Tumor-Targeted Theranostics[J]. ACS nano. 2018 Dec 26;12(12):12380-12392.

Citations

1. Wang S, Li F, Qiao R, et al. Arginine-Rich Manganese Silicate Nanobubbles as a Ferroptosis-Inducing Agent for Tumor-Targeted Theranostics. ACS nano. 2018 Dec 26;12(12):12380-12392. 2. Lin X, Lin T, Wang X, et al.Sesamol serves as a p53 stabilizer to relieve rheumatoid arthritis progression and inhibits the growth of synovial organoids.Phytomedicine.2023: 155109. 3. Jin T, Wu L, Wang J, et al.Exosomes derived from diabetic serum accelerate the progression of osteoarthritis.Archives of Biochemistry and Biophysics.2024: 109960.

Related compound libraries

This product is contained In the following compound libraries：

Membrane Protein-targeted Compound Library Drug Repurposing Compound Library Anti-Cancer Drug Library Inhibitor Library Tobacco Monomer Library Anti-Cancer Clinical Compound Library Miao medicine Compound Library Anti-Cancer Approved Drug Library Microbial Natural Product Library Pyroptosis Compound Library

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Keywords

L-Ascorbic acid 50-81-7 Apoptosis Immunology/Inflammation Membrane transporter/Ion channel Metabolism NF-Κb Endogenous Metabolite Calcium Channel Reactive Oxygen Species donor antioxidant ROS oxygen Ca channels cancer Electron channel Inhibitor Ca2+ channels inhibit collagen L Ascorbic acid reactive Vitamin C Cav3.2 Ascorbic acid species deposition L(+)-Ascorbic acid L-Ascorbate LAscorbic acid inhibitor

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