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Risperidone

Catalog No. T0351 CAS 106266-06-2

Synonyms: Dopamine Receptor, inhibit, P-gp, Cluster of differentiation 243, Multidrug resistance protein 1, 5-hydroxytryptamine Receptor, CD243, MDR1, Inhibitor, R 64 766, P-glycoprotein, Serotonin Receptor, Risperidal, Pgp, ABCB1, 5-HT Receptor, Risperidone

Risperidone is a selective blocker of dopamine D2 receptors and serotonin 5-HT2 receptors that act as an atypical antipsychotic agent.

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Risperidone, CAS 106266-06-2

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Risperidone is a selective blocker of dopamine D2 receptors and serotonin 5-HT2 receptors that act as an atypical antipsychotic agent.
Targets&IC50	α2c-adrenergic receptor:1.3 nM(Ki), D2 receptor:3.57 nM(Ki), 5-HT2A:0.17 nM(Ki), D2L Receptor:4.16 nM(Ki), D3 receptor:3.6 nM(Ki)

Synonyms	Dopamine Receptor, inhibit, P-gp, Cluster of differentiation 243, Multidrug resistance protein 1, 5-hydroxytryptamine Receptor, CD243, MDR1, Inhibitor, R 64 766, P-glycoprotein, Serotonin Receptor, Risperidal, Pgp, ABCB1, 5-HT Receptor, Risperidone
Molecular Weight	410.493
Formula	C23H27FN4O2
CAS No.	106266-06-2

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 4.1 mg/mL (10 mM)

Ethanol: 4.1 mg/mL (10 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Angelucci F, et al. J Neurosci Res,2000, 60(6), 783-794. 1. Wesołowska A, Rychtyk J, Gdula-Argasińska J, et al Effect of 5-HT6 Receptor Ligands Combined with Haloperidol or Risperidone on Antidepressant-/Anxiolytic-Like Behavior and BDNF Regulation in Hippocampus and Prefrontal Cortex of Rats. Neuropsychiatric Disease and Treatment. 2021, 17: 2105. 2. Wesołowska, Anna, et al. Effect of 5-HT 6 Receptor Ligands Combined with Haloperidol or Risperidone on Antidepressant-/Anxiolytic-Like Behavior and BDNF Regulation in Hippocampus and Prefrontal Cortex of Rats. Neuropsychiatric Disease and Treatment 17. (2021): 2105-2127. 2. Tarazi FI, et al. J Pharmacol Exp Ther,2001, 297(2), 711-717. 3. Kato T, et al. Schizophr Res,2007, 92(1-3), 108-115. 4. Zhu HJ, et al. Neuropsychopharmacology,2007, 32(4), 757-764. 5. Baptista T, et al. Brain Res,2002, 957(1), 144-151.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Anti-Cardiovascular Disease Compound Library Serotonin Receptor-Targeted Compound Library Histamine & Melatonin Receptor-Targeted Compound Library Anti-Obesity Compound Library Neurotransmitter Receptor Compound Library Endocrinology-Hormone Compound Library Anti-Parkinson's Disease Compound Library Inhibitor Library Drug-induced Liver Injury (DILI) Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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