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Risperidone

Catalog No. T0351   CAS 106266-06-2
Synonyms: R 64 766, Risperidal

Risperidone is a selective blocker of dopamine D2 receptors and serotonin 5-HT2 receptors that act as an atypical antipsychotic agent.

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Risperidone, CAS 106266-06-2
Pack Size Availability Price/USD Quantity
10 mg In stock $ 45.00
25 mg In stock $ 54.00
50 mg In stock $ 85.00
100 mg In stock $ 130.00
200 mg In stock $ 221.00
500 mg In stock $ 377.00
1 mL * 10 mM (in DMSO) In stock $ 50.00
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Purity: 100%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Risperidone is a selective blocker of dopamine D2 receptors and serotonin 5-HT2 receptors that act as an atypical antipsychotic agent.
Targets&IC50 D2 receptor:3.57 nM(Ki), α2c-adrenergic receptor:1.3 nM(Ki), D2L Receptor:4.16 nM(Ki), D3 receptor:3.6 nM(Ki), 5-HT2A:0.17 nM(Ki)
Synonyms R 64 766, Risperidal
Molecular Weight 410.48
Formula C23H27FN4O2
CAS No. 106266-06-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

DMSO: 4.1 mg/mL (10 mM)

Ethanol: 4.1 mg/mL (10 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Angelucci F, et al. J Neurosci Res,2000, 60(6), 783-794. 2. Tarazi FI, et al. J Pharmacol Exp Ther,2001, 297(2), 711-717. 3. Kato T, et al. Schizophr Res,2007, 92(1-3), 108-115. 4. Zhu HJ, et al. Neuropsychopharmacology,2007, 32(4), 757-764. 5. Baptista T, et al. Brain Res,2002, 957(1), 144-151.

Citations

1. Wesołowska A, Rychtyk J, Gdula-Argasińska J, et al Effect of 5-HT6 Receptor Ligands Combined with Haloperidol or Risperidone on Antidepressant-/Anxiolytic-Like Behavior and BDNF Regulation in Hippocampus and Prefrontal Cortex of Rats. Neuropsychiatric Disease and Treatment. 2021, 17: 2105. 2. Partyka A, Górecka K, Gdula-Argasińska J, et al.Selective 5-HT6 Receptor Ligands (Agonist and Antagonist) Show Different Effects on Antipsychotic Drug-Induced Metabolic Dysfunctions in Rats.Pharmaceuticals.2023, 16(2): 154.

Related compound libraries

This product is contained In the following compound libraries:
Neurotransmitter Receptor Compound Library FDA-Approved & Pharmacopeia Drug Library Histamine & Melatonin Receptor-Targeted Compound Library Orally Active Compound Library Bioactive Compound Library Anti-Cancer Drug Library Anti-Alzheimer's Disease Compound Library Anti-Hypertension Compound Library Anti-Parkinson's Disease Compound Library Anti-Cancer Clinical Compound Library

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Keywords

Risperidone 106266-06-2 GPCR/G Protein Membrane transporter/Ion channel Neuroscience P-gp 5-HT Receptor Dopamine Receptor Adrenergic Receptor inhibit Cluster of differentiation 243 Multidrug resistance protein 1 5-hydroxytryptamine Receptor CD243 MDR1 Inhibitor R 64 766 P-glycoprotein Serotonin Receptor Risperidal Pgp ABCB1 inhibitor