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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $64 | In Stock | |
2 mg | $93 | In Stock | |
5 mg | $156 | In Stock | |
10 mg | $255 | In Stock | |
25 mg | $448 | In Stock | |
50 mg | $662 | In Stock | |
100 mg | $987 | In Stock | |
500 mg | $1,980 | In Stock | |
1 mL x 10 mM (in DMSO) | $172 | In Stock |
Description | SEP-363856 hydrochloride (SEP-856 hydrochloride) is an orally active, CNS-active psychotropic agent with a unique non-D2/5-HT2A mechanism of action, demonstrating antipsychotic-like effects and potential for schizophrenia treatment. |
Targets&IC50 | 5-HT1D receptor:0.262 μM (EC50), 5-HT2C receptor:30 μM (EC50), 5-HT7 receptor:6.7 μM (EC50), 5-HT1A receptor:2.3 μM (EC50), TAAR1:0.140 μM (EC50), 5-HT2A receptor:10 μM (EC50), 5-HT1B receptor:15.6 μM (EC50) |
In vitro | SEP-856 (10μM) specifically inhibits α2A, α2B, D2, 5-HT1A, 5-HT1B, 5-HT1D, 5-HT2A, 5-HT2B, 5-HT2C and 5-HT7> 50% receptor. |
In vivo | SEP-856 (0.3, 1, and 10 mg/kg, i.p.) is CNS active and exhibits a behavioral signature similar to known antipsychotic drugs. PCP-induced hyperactivity is significantly reduced by SEP-856 (0.3, 1, and 10 mg/kg, orally once). Oral SEP-856 administration (1, 3, and 10 mg/kg) produces a dose-dependent decrease in REM sleep, increase in latency to REM sleep, and increase in cumulative wake (W) time. |
Alias | SEP-856 hydrochloride |
Molecular Weight | 219.73 |
Formula | C9H14ClNOS |
Cas No. | 1310422-41-3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 55 mg/mL (250.31 mM), Sonication is recommended. ![]() | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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