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SEP-363856 hydrochloride
🥰Excellent
Catalog No. T12899LCas No. 1310422-41-3
Alias SEP-856 hydrochloride
SEP-363856 hydrochloride (SEP-856 hydrochloride) is an orally active, CNS-active psychotropic agent with a unique non-D2/5-HT2A mechanism of action, demonstrating antipsychotic-like effects and potential for schizophrenia treatment.
SEP-363856 hydrochloride
🥰Excellent
Purity: 99.99%
Catalog No. T12899LAlias SEP-856 hydrochlorideCas No. 1310422-41-3
SEP-363856 hydrochloride (SEP-856 hydrochloride) is an orally active, CNS-active psychotropic agent with a unique non-D2/5-HT2A mechanism of action, demonstrating antipsychotic-like effects and potential for schizophrenia treatment.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $64 | In Stock | |
| 2 mg | $93 | In Stock | |
| 5 mg | $156 | In Stock | |
| 10 mg | $255 | In Stock | |
| 25 mg | $448 | In Stock | |
| 50 mg | $662 | In Stock | |
| 100 mg | $987 | In Stock | |
| 500 mg | $1,980 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $172 | In Stock |
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CitedSelect Batch
Purity:99.99%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | SEP-363856 hydrochloride (SEP-856 hydrochloride) is an orally active, CNS-active psychotropic agent with a unique non-D2/5-HT2A mechanism of action, demonstrating antipsychotic-like effects and potential for schizophrenia treatment. |
| Targets&IC50 | 5-HT1D receptor:0.262 μM （EC50）, 5-HT1A receptor:2.3 μM （EC50）, 5-HT2C receptor:30 μM （EC50）, 5-HT1B receptor:15.6 μM （EC50）, 5-HT7 receptor:6.7 μM （EC50）, 5-HT2A receptor:10 μM （EC50）, TAAR1:0.140 μM （EC50） |
| In vitro | SEP-856 (10μM) specifically inhibits α2A, α2B, D2, 5-HT1A, 5-HT1B, 5-HT1D, 5-HT2A, 5-HT2B, 5-HT2C and 5-HT7> 50% receptor. |
| In vivo | SEP-856 (0.3, 1, and 10 mg/kg, i.p.) is CNS active and exhibits a behavioral signature similar to known antipsychotic drugs. PCP-induced hyperactivity is significantly reduced by SEP-856 (0.3, 1, and 10 mg/kg, orally once). Oral SEP-856 administration (1, 3, and 10 mg/kg) produces a dose-dependent decrease in REM sleep, increase in latency to REM sleep, and increase in cumulative wake (W) time. |
| Alias | SEP-856 hydrochloride |
| Molecular Weight | 219.73 |
| Formula | C9H14ClNOS |
| Cas No. | 1310422-41-3 |
| Smiles | Cl.CNC[C@@H]1OCCc2ccsc12 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 55 mg/mL (250.31 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords
Serotonin ReceptorSEP-856 HydrochlorideSEP856 HydrochlorideSEP-856SEP856SEP-363856 HydrochlorideSEP363856 HydrochlorideSEP363856 hydrochlorideSEP-363856SEP363856SEP 856 HydrochlorideSEP 856SEP 363856 hydrochlorideSEP 363856 HydrochlorideSEP 363856Inhibitorinhibit5-hydroxytryptamine Receptor5HTReceptor5-HT Receptor5HT Receptor
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