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T-1101 tosylate

Catalog No. T8216 CAS 2250404-95-4

Synonyms: TAI-95 tosylate

T-1101 tosylate (TAI-95 tosylate) is an inhibitor of Hec1/Nek2, with antitumor activity.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

T-1101 tosylate, CAS 2250404-95-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 74.00
5 mg	In stock	$ 178.00
10 mg	In stock	$ 289.00
25 mg	In stock	$ 538.00
50 mg	In stock	$ 778.00
100 mg	In stock	$ 1,090.00
1 mL * 10 mM (in DMSO)	In stock	$ 265.00

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Purity: 98.47%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	T-1101 tosylate (TAI-95 tosylate) is an inhibitor of Hec1/Nek2, with antitumor activity.
In vitro	T-1101 has good oral absorption, along with potent in?vitro antiproliferative activity (IC50: 14.8-21.5?nM).
In vivo	T-1101 tosylate can achieve high concentrations in Huh-7 and MDA-MB-231 tumor tissues, and showed promise in antitumor activity in mice bearing human tumor xenografts of liver cancer (Huh-7).
Animal Research	SCID mice bearing human Huh-7, BT-474, MCF-7, and MDA-MB-231 xenografts. Dosage:25 mg/kg, 50 mg/kg. Oral administration; twice per day; 28 days

Synonyms	TAI-95 tosylate
Molecular Weight	665.8
Formula	C31H31N5O6S3
CAS No.	2250404-95-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 11 mg/mL (16.52 mM)

References and Literature

1. Chuang SH, et al. Discovery of T-1101 tosylate as a first-in-class clinical candidate for Hec1/Nek2 inhibition in cancer therapy. Eur J Med Chem. 2020 Apr 1;191:112118.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Anti-Cancer Clinical Compound Library Microtubule-Targeted Compound Library Anti-Cancer Drug Library Inhibitor Library Drug Repurposing Compound Library Apoptosis Compound Library Bioactive Compounds Library Max Bioactive Compound Library Anti-Cancer Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

T-1101 tosylate 2250404-95-4 Apoptosis Cytoskeletal Signaling Microtubule Associated TAI95 T1101 Tosylate T1101 tosylate T-1101 Tosylate TAI95 Tosylate TAI-95 T 1101 Tosylate T1101 Inhibitor inhibit T 1101 T-1101 TAI-95 tosylate TAI-95 Tosylate PPI TAI 95 Hec1/Nek2 TAI 95 Tosylate T 1101 tosylate inhibitor

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