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Trifluoperazine dihydrochloride

Catalog No. T1222   CAS 440-17-5
Synonyms: Trifluoperazine 2HCl, SKF5019, Urinox

Trifluoperazine dihydrochloride (SKF5019) is a potent dopamine D2 receptor inhibitor used as an antipsychotic and an antiemetic.

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Trifluoperazine dihydrochloride Chemical Structure
Trifluoperazine dihydrochloride, CAS 440-17-5
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100 mg In stock $ 50.00
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Purity: 100%
Purity: 99.96%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Trifluoperazine dihydrochloride (SKF5019) is a potent dopamine D2 receptor inhibitor used as an antipsychotic and an antiemetic.
Targets&IC50 Dopamine D2 receptor:1.1 nM
In vitro Trifluoperazine binds to α1A- and α1B-adrenoceptor with Ki value of 27.6 nM and 19.2 nM, respectively, with α1B/α1A ratio of 0.7. [2] Trifluoperazine inhibits Mycobacterium tuberculosis (Mtb) with MICs of 7.6 μg/mL. [3] Trifluoperazine (< 14.78 mM) suppresses the activities of the mouse splenic NK cell cytotoxicity and the effector-target cell conjugation in a dose dependent manner. Trifluoperazine suppresses interferon-alpha or interleukin-2 induced augmentation of the cytolytic activity of NK cells. [4] Trifluoperazine inhibits the gene expression of voltage-dependent potassium channel Kv2.1 from human brain (hKv2.1). [5]
In vivo Trifluoperazine dose dependently decreases avoidance responses and increases response failures in rats where behavior is maintained under a discrete-trial avoidance. [6]
Synonyms Trifluoperazine 2HCl, SKF5019, Urinox
Molecular Weight 480.43
Formula C21H26Cl2F3N3S
CAS No. 440-17-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 88 mg/mL (183.2 mM)

DMSO: 82 mg/mL (170.7 mM)

Ethanol: 89 mg/mL (185.3 mM)

TargetMolReferences and Literature

1. Lahti RA, et al. Eur J Pharmacol, 1993, 236(3), 483-486. 2. Cahir M, et al. Eur Neuropsychopharmacol, 2005, 15(2), 231-234. 3. Madrid PB, et al. Bioorg Med Chem Lett, 2007, 17(11), 32014-32017. 4. Won SJ, et al. Experientia, 1995, 51(4), 343-348. 5. Motohashi N, et al. Curr Drug Targets, 2000, 1(3), 237-245.

TargetMolCitations

1. Wang J, Liang M, Shang Q, et al.Psilocin suppresses methamphetamine‐induced hyperlocomotion and acquisition of conditioned place preference via D2R‐mediated ERK signaling.CNS Neuroscience & Therapeutics.2023

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Drug Library Anti-Cancer Active Compound Library Anti-Cancer Approved Drug Library Anti-Neurodegenerative Disease Compound Library Anti-Alzheimer's Disease Compound Library NO PAINS Compound Library Neuronal Signaling Compound Library CNS-Penetrant Compound Library Anti-Cancer Compound Library GPCR Compound Library

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Keywords

Trifluoperazine dihydrochloride 440-17-5 Autophagy GPCR/G Protein Membrane transporter/Ion channel Microbiology/Virology Neuroscience CaMK Dopamine Receptor Influenza Virus Adrenergic Receptor P-gp SKF 5019 Inhibitor anticancer Multidrug resistance protein 1 Trifluoperazine 2HCl MDR1 inhibit Beta Receptor Calmodulin-dependent protein kinases ABCB1 SKF-5019 schizophrenia SKF5019 Cluster of differentiation 243 Trifluoperazine Trifluoperazine Dihydrochloride P-glycoprotein CD243 Calmodulin-dependent kinases Urinox NUPR1 morphogenesis Pgp antipsychotic inhibitor

 

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