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Valproic Acid

Catalog No. T7064 CAS 99-66-1

Synonyms: Sodium valproate, 2-Propylpentanoic Acid, VPA, Depakine, 2-Propylvaleric Acid

Valproic Acid (2-Propylpentanoic Acid) is an HDAC inhibitor that inhibits HDAC1 activity, induces HDAC2 degradation, and is orally active. Valproic Acid can be used in epilepsy and bipolar disorder research.

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Valproic Acid, CAS 99-66-1

Pack Size	Availability	Price/USD	Quantity
1 g	In stock	$ 50.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.49%

Purity: 99%

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Description	Valproic Acid (2-Propylpentanoic Acid) is an HDAC inhibitor that inhibits HDAC1 activity, induces HDAC2 degradation, and is orally active. Valproic Acid can be used in epilepsy and bipolar disorder research.
Targets&IC50	HDAC1:0.4 mM
In vitro	METHODS: Esophageal squamous cell carcinoma (ESCC) cell lines TE9, TE10, TE11, and TE14 were treated with Valproic Acid (0.01-5 mM) for 72 h, and cell viability was assayed using MTT Assay. RESULTS: Valproic Acid inhibited the viability of all ESCC cells in a dose-dependent manner. The IC50 values of Valproic Acid ranged from 1.02-2.15 mM in each cell line. [1] METHODS: Mouse teratoma cells, F9, and human cervical cancer cells, HeLa, were treated with Valproic Acid (0.25-5 mM) for 4-24 h. The expression levels of target proteins were detected by Western Blot. RESULTS: Only trace amounts of acetylated histones were detected in untreated F9 or HeLa cells. Treatment with Valproic Acid at concentrations as low as 0.25 mM increased the amount of acetylated histone H4, and significant acetylation was found with 2 mM Valproic Acid. [2]
In vivo	METHODS: To study the effects on Machado Joseph disease (MJD), Valproic Acid (200 mg/kg) was administered intraperitoneally to the CMVMJD135 mouse model five times per week for twenty-five weeks. RESULTS: Chronic Valproic Acid treatment had limited effects on motor deficits in these mice, observed primarily in the late stages of locomotor swimming, beam swimming, rotational bar and spontaneous motor activity tests, and did not alter ATXN3 inclusion body loads and astrocyte proliferation in affected brain regions. [3] METHODS: To assay antitumor activity in vivo, Valproic Acid (500 mg/kg, 10% DMSO 25% w/v Kleptose HPB buffer) was administered by gavage to BALB/c nude mice harboring the human AML tumor, Kasumi-1, once daily for twelve days. RESULTS: Valproic Acid inhibited tumor growth in mice transplanted with Kasumi-1 cells. At the end of the experiment, the incidence of IR in the Valproic Acid group was 57.25%. [4]

Synonyms	Sodium valproate, 2-Propylpentanoic Acid, VPA, Depakine, 2-Propylvaleric Acid
Molecular Weight	144.21
Formula	C8H16O2
CAS No.	99-66-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (693.43 mM), Sonification is recommended.

H2O: 1 mg/mL (6.93 mM), Sonification and heating are recommended.

References and Literature

1. Shoji M, et al. Valproic acid, a histone deacetylase inhibitor, enhances radiosensitivity in esophageal squamous cell carcinoma. Int J Oncol. 2012 Jun;40(6):2140-6. 2. Göttlicher M, et al. Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells. EMBO J. 2001 Dec 17;20(24):6969-78. 3. Esteves S, et al. Limited Effect of Chronic Valproic Acid Treatment in a Mouse Model of Machado-Joseph Disease. PLoS One. 2015 Oct 27;10(10):e0141610. 4. Zhang ZH, et al. Valproic acid inhibits tumor angiogenesis in mice transplanted with Kasumi‑1 leukemia cells. Mol Med Rep. 2014 Feb;9(2):443-9.

Citations

1. Zhu Z A, Li Y Y, Xu J, et al.CDKL5 deficiency in adult glutamatergic neurons alters synaptic activity and causes spontaneous seizures via TrkB signaling.Cell Reports.2023, 42(10). 2. Han L, Song B, Zhang P, et al.PC3T: a signature-driven predictor of chemical compounds for cellular transition.Communications Biology.2023, 6(1): 989.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Clinical Compound Library Anti-Neurodegenerative Disease Compound Library Anti-Cancer Active Compound Library Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Inhibitor Library Drug Repurposing Compound Library RO5 Drug-like Natural Product Library Natural Product Library for HTS Stem Cell Differentiation Compound Library

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Keywords

Valproic Acid 99-66-1 Autophagy Chromatin/Epigenetic DNA Damage/DNA Repair Membrane transporter/Ion channel Microbiology/Virology Neuroscience Proteases/Proteasome Stem Cells Mitophagy Gamma-secretase GABA Receptor HIV Protease HDAC Sodium Channel Histone deacetylases Mitochondrial Autophagy bipolar disorder epilepsy Apoptosis hepatic fat accumulation headaches Inhibitor Sodium valproate migraine anticancer Human immunodeficiency virus small cell lung cancer inhibit 2-Propylpentanoic Acid proteasomal degradation SCLC anticonvulsant Endogenous Metabolite VPA Notch1 Depakine HIV Notch 2-Propylvaleric Acid inhibitor

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