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Cinanserin hydrochloride
🥰Excellent
Catalog No. T14968Cas No. 54-84-2
Alias SQ 10643
Cinanserin hydrochloride (SQ 10643), a high-affinity antagonist of the 5-HT2 receptor (Ki: 41 nM), is also a 3C-like protease inhibitor of severe acute respiratory syndrome coronavirus.
Cinanserin hydrochloride
🥰Excellent
Purity: 99.32%
Catalog No. T14968Alias SQ 10643Cas No. 54-84-2
Cinanserin hydrochloride (SQ 10643), a high-affinity antagonist of the 5-HT2 receptor (Ki: 41 nM), is also a 3C-like protease inhibitor of severe acute respiratory syndrome coronavirus.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $30 | In Stock | |
| 5 mg | $68 | In Stock | |
| 10 mg | $109 | In Stock | |
| 25 mg | $218 | In Stock | |
| 50 mg | $397 | In Stock | |
| 100 mg | $597 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $119 | In Stock |
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Purity:99.32%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Cinanserin hydrochloride (SQ 10643), a high-affinity antagonist of the 5-HT2 receptor (Ki: 41 nM), is also a 3C-like protease inhibitor of severe acute respiratory syndrome coronavirus. |
| Targets&IC50 | 3CLpro:, 5-HT2 receptor:41 nM (ki) |
| In vitro | Cinanserin and Cinanserin hydrochloride inhibit the catalytic activity of SARS-CoV 3CLpro and HCoV-229E 3CLpro (IC50: 4.68 μM and 5.68 μM). Cinanserin/Cinanserin hydrochloride has a binding affinity to SARS-CoV 3CLpro, HCoV-229E 3CLpro, with the KD values of 49.4 μM/78.0 μM for SARS-associated coronavirus (SARS-CoV) 3CLpro[1]. |
| In vivo | Cinanserin (5 mg/kg; intravenous injection; 2 hours; male Wistar rats) treatment significantly reduces systemic burn edema to shamburn levels[2]. |
| Alias | SQ 10643 |
| Molecular Weight | 376.94 |
| Formula | C20H25ClN2OS |
| Cas No. | 54-84-2 |
| Smiles | Cl.CN(C)CCCSc1ccccc1NC(=O)C=Cc1ccccc1 |
| Relative Density. | 1.22 g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 125 mg/mL (331.62 mM), Sonication is recommended. H2O: 100 mg/mL (265.29 mM）, Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O/DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords
virussystemicSQ-10643SQ10643Serotonin ReceptorreplicationproteinaseleukocyteInhibitorinhibitInfluenzaVirusInfluenza VirusendothelialedemaCinanserin hydrochlorideCinanserin HydrochlorideCinanserinburn5-hydroxytryptamine Receptor5HTReceptor5-HT2 Receptor5-HT25-HT Receptor5HT Receptor3C-like proteinase3C-like
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