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Desipramine hydrochloride
🥰Excellent
Catalog No. T0991Cas No. 58-28-6
Alias NSC-114901, Norimipramine, JB-8181, G-35020, EX-4355, Desmethylimipramine
Desipramine hydrochloride (Norimipramine) ,a secondary amine tricyclic antidepressant (TCA), is the hydrochloride salt form of desipramine. In the central nervous system (CNS), Desipramine hydrochloride blocks the re-uptake of neurotransmitters, including norepinephrine and serotonin. This leads to an increase in the amount of these neurotransmitters in the synaptic cleft and prolongs their activities postsynaptically.
Desipramine hydrochloride
🥰Excellent
Purity: 99.94%
Catalog No. T0991Alias NSC-114901, Norimipramine, JB-8181, G-35020, EX-4355, DesmethylimipramineCas No. 58-28-6
Desipramine hydrochloride (Norimipramine) ,a secondary amine tricyclic antidepressant (TCA), is the hydrochloride salt form of desipramine. In the central nervous system (CNS), Desipramine hydrochloride blocks the re-uptake of neurotransmitters, including norepinephrine and serotonin. This leads to an increase in the amount of these neurotransmitters in the synaptic cleft and prolongs their activities postsynaptically.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 mg | $35 | In Stock | |
| 100 mg | $48 | In Stock | |
| 200 mg | $61 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $30 | In Stock |
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- $45
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Purity:99.94%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Desipramine hydrochloride (Norimipramine) ,a secondary amine tricyclic antidepressant (TCA), is the hydrochloride salt form of desipramine. In the central nervous system (CNS), Desipramine hydrochloride blocks the re-uptake of neurotransmitters, including norepinephrine and serotonin. This leads to an increase in the amount of these neurotransmitters in the synaptic cleft and prolongs their activities postsynaptically. |
| Targets&IC50 | SERT:61 nM (Ki), NET:4 nM (Ki), DAT:78720 nM (Ki) |
| Alias | NSC-114901, Norimipramine, JB-8181, G-35020, EX-4355, Desmethylimipramine |
| Molecular Weight | 302.842 |
| Formula | C18H23ClN2 |
| Cas No. | 58-28-6 |
| Smiles | Cl.CNCCCN1c2ccccc2CCc2ccccc12 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (165.1 mM)  | |||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords
SLC6A4SLC6A3SERTSerotoninTransporterSerotonin TransporterNSC114901NSC 114901JB8181JB 8181InhibitorinhibitG35020G 35020EX4355EX 4355DopamineReceptorDopamine TransporterDopamine ReceptorDesipramine hydrochlorideDesipramine HydrochlorideDesipramineDATAdrenergicReceptorAdrenergic Receptor5-HTT5HTReceptor5HT Receptor
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