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Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $38 | In Stock | |
5 mg | $60 | In Stock | |
10 mg | $98 | In Stock | |
25 mg | $162 | In Stock | |
50 mg | $238 | In Stock | |
100 mg | $357 | In Stock | |
1 mL x 10 mM (in DMSO) | $62 | In Stock |
Description | DOV-216,303 Free Base (DOV-216303) is an inhibitor of serotonin, norepinephrine, and dopamine reuptake with with IC50s of 14, 20 and 78 nM. DOV-216,303 Free Base exhibits antidepressant effects. |
Targets&IC50 | Norepinephrine:20 nM , 5-HT:14 nM , Dopamine:78 nM |
In vivo | In male Sprague Dawley rats of OBX or Sham surgery, DOV 216,303 (20 mg/kg; i.p.; choronic) increases extracellular concentrations of dopamine, norepinephrine and serotonin and significantly increases extracellular baseline serotonin concentrations while DOV-216,303 (20 mg/kg; i.p.; acute) significantly increases dopamine, norepinephrine and serotonin levels[2]. |
Alias | DOV-216303 |
Molecular Weight | 228.12 |
Formula | C11H11Cl2N |
Cas No. | 66504-40-3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 125 mg/mL (547.96 mM) Ethanol: 95 mg/mL (416.45 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
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