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Mivacurium dichloride

Catalog No. T22371Cas No. 106861-44-3
Alias Mivacurium chloride

Mivacurium dichloride (Mivacurium chloride) is a non-depolarising, rapid neuromuscular blocker of short duration, used therefore as anesthetic, to provide skeletal muscle relaxation in minor surgical operations, in emergency surgical procedures of short to intermediate duration and during intubation of the trachea.

Mivacurium dichloride

Mivacurium dichloride

Purity: 99.52%
Catalog No. T22371Alias Mivacurium chlorideCas No. 106861-44-3
Mivacurium dichloride (Mivacurium chloride) is a non-depolarising, rapid neuromuscular blocker of short duration, used therefore as anesthetic, to provide skeletal muscle relaxation in minor surgical operations, in emergency surgical procedures of short to intermediate duration and during intubation of the trachea.
Pack SizePriceAvailabilityQuantity
2 mg$40In Stock
5 mg$63In Stock
10 mg$91In Stock
25 mg$132In Stock
50 mg$209In Stock
100 mg$318In Stock
200 mg$482In Stock
1 mL x 10 mM (in DMSO)$97In Stock
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Purity:99.52%
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Product Introduction

Bioactivity
Description
Mivacurium dichloride (Mivacurium chloride) is a non-depolarising, rapid neuromuscular blocker of short duration, used therefore as anesthetic, to provide skeletal muscle relaxation in minor surgical operations, in emergency surgical procedures of short to intermediate duration and during intubation of the trachea.
In vitro
Mivacurium caused pseudo-allergic reactions in wild-type mice by inducing mast cells to release histamine.?However, it did not induce a similar phenomenon in KitW-sh/W-sh mice.?Furthermore, MrgprB2-knockout mice displayed no inflammatory response to mivacurium.?Mivacurium induced LAD2 cell degranulation in a dose-dependent manner.?Mivacurium stimulated intracellular calcium ion (Ca2+) influx in MRGPRX2-HEK293 cells but not in NC-HEK293 cells.?However, mivacurium induced the release of only low levels of mediators in LAD2 cells transfected with MRGPRX2-targeted small interfering (si)RNA.?Notably, cytokine release was not observed in LAD2 cells even when stimulated with high concentrations of mivacurium[1].
In vivo
Mivacurium is rapidly hydrolyzed in the plasma with a short duration of action(< 10 min). Mivacurium has lots of advantages, like a rapid effect, nonneurological toxicity and a lack of heart rate alteration. Mivacurium causes pseudo-allergic reactions in C57 wild-type mice by inducing mast cells to release histamine and a decrease in body temperature[1]. 
AliasMivacurium chloride
Chemical Properties
Molecular Weight1100.17
FormulaC58H80Cl2N2O14
Cas No.106861-44-3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
Ethanol: 100 mg/ml (90.9 mM)
DMSO: 100 mg/ml (90.9 mM)
H2O: 100 mg/ml (90.9 mM)
Solution Preparation Table
Ethanol/DMSO/H2O
1mg5mg10mg50mg
1 mM0.9090 mL4.5448 mL9.0895 mL45.4475 mL
5 mM0.1818 mL0.9090 mL1.8179 mL9.0895 mL
10 mM0.0909 mL0.4545 mL0.9090 mL4.5448 mL
20 mM0.0454 mL0.2272 mL0.4545 mL2.2724 mL
50 mM0.0182 mL0.0909 mL0.1818 mL0.9090 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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