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Xanomeline

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Catalog No. T36640Cas No. 131986-45-3
Alias LY-246708

Xanomeline (LY-246708) is a functionally selective M1/M4 activator used in the study of neurological disorders such as schizophrenia and has shown promising treatment in preclinical trials. Xanomeline is well absorbed orally, crosses the blood-brain barrier and undergoes extensive liver metabolism with at least six metabolites.

Xanomeline

Xanomeline

🥰Excellent
Purity: 99.61%
Catalog No. T36640Alias LY-246708Cas No. 131986-45-3
Xanomeline (LY-246708) is a functionally selective M1/M4 activator used in the study of neurological disorders such as schizophrenia and has shown promising treatment in preclinical trials. Xanomeline is well absorbed orally, crosses the blood-brain barrier and undergoes extensive liver metabolism with at least six metabolites.
Pack SizePriceAvailabilityQuantity
5 mg$50In Stock
10 mg$96In Stock
25 mg$168In Stock
50 mg$298In Stock
100 mg$489In Stock
1 mL x 10 mM (in DMSO)$60In Stock
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Purity:99.61%
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Product Introduction

Bioactivity
Description
Xanomeline (LY-246708) is a functionally selective M1/M4 activator used in the study of neurological disorders such as schizophrenia and has shown promising treatment in preclinical trials. Xanomeline is well absorbed orally, crosses the blood-brain barrier and undergoes extensive liver metabolism with at least six metabolites.
In vitro
In binding studies pre-incubating cells for one hour with 1 μM xanomeline, but not carbachol, reduced N-[3H]methylscopolamine saturation binding affinity but not maximal receptor density in cells
[1].
In vivo
Animal studies have shown the role of M4 and M1 receptors in modulating psychotic and behavioral disturbances and correction of negative and/or cognitive symptoms, respectively. The time to reach maximum plasma concentration (Tmax) for xanomeline is 2.5 hours, and maximum plasma concentration following xanomeline 150mg is 13.8ng/mL. Xanomeline is widely distributed, including to the CNS in animal studies, and the majority of the drug is excreted via the kidneys within 24 hours of administration[2].
AliasLY-246708
Chemical Properties
Molecular Weight281.42
FormulaC14H23N3OS
Cas No.131986-45-3
SmilesCCCCCCOc1nsnc1C1=CCCN(C)C1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 4.5 mg/mL (15.99 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.5534 mL17.7670 mL35.5341 mL177.6704 mL
5 mM0.7107 mL3.5534 mL7.1068 mL35.5341 mL
10 mM0.3553 mL1.7767 mL3.5534 mL17.7670 mL

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