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Xanomeline

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Purity:99.61%

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COA HNMR HPLC

Xanomeline

Catalog No. T36640Cas No. 131986-45-3

Xanomeline (LY-246708) is a functionally selective M1/M4 activator used in the study of neurological disorders such as schizophrenia and has shown promising treatment in preclinical trials. Xanomeline is well absorbed orally, crosses the blood-brain barrier and undergoes extensive liver metabolism with at least six metabolites.

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Pack Size	Price	Availability
5 mg	$30	In Stock
10 mg	$48	In Stock
25 mg	$97	In Stock
50 mg	$157	In Stock
100 mg	$253	In Stock
1 mL x 10 mM (in DMSO)	$31	In Stock

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Product Introduction

Bioactivity

Description	Xanomeline (LY-246708) is a functionally selective M1/M4 activator used in the study of neurological disorders such as schizophrenia and has shown promising treatment in preclinical trials. Xanomeline is well absorbed orally, crosses the blood-brain barrier and undergoes extensive liver metabolism with at least six metabolites.
In vitro	In binding studies pre-incubating cells for one hour with 1 μM xanomeline, but not carbachol, reduced N-[3H]methylscopolamine saturation binding affinity but not maximal receptor density in cells [1].
In vivo	Animal studies have shown the role of M4 and M1 receptors in modulating psychotic and behavioral disturbances and correction of negative and/or cognitive symptoms, respectively. The time to reach maximum plasma concentration (Tmax) for xanomeline is 2.5 hours, and maximum plasma concentration following xanomeline 150mg is 13.8ng/mL. Xanomeline is widely distributed, including to the CNS in animal studies, and the majority of the drug is excreted via the kidneys within 24 hours of administration[2].
Alias	LY-246708

Chemical Properties

Molecular Weight	281.42
Formula	C14H23N3OS
Cas No.	131986-45-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 4.5 mg/mL (15.99 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5534 mL	17.7670 mL	35.5341 mL	177.6704 mL
5 mM	0.7107 mL	3.5534 mL	7.1068 mL	35.5341 mL
10 mM	0.3553 mL	1.7767 mL	3.5534 mL	17.7670 mL

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