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Metoclopramide

Catalog No. T4616 CAS 364-62-5

Synonyms: 5-Chloro-2-methoxyprocainamide

Metoclopramide (5-Chloro-2-methoxyprocainamide) is a dopamine D2 antagonist which has been used for treatment of a variety of gastrointestinal symptoms over the last thirty years. In various countries, metoclopramide is the antiemetic drug of choice in pregnant women. Findings provide reassurance regarding the safety of metoclopramide for the fetus when the drug is given to women to relieve nausea and vomiting during pregnancy. Evidence also supports its use for gastroparesis (poor stomach emptying) and gastroesophageal reflux disease. It appears to bind to dopamine D2 receptors where it is a receptor antagonist, and is also a mixed 5-HT3 receptor antagonist/ 5-HT4 receptor agonist.

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Metoclopramide, CAS 364-62-5

Pack Size	Availability	Price/USD
50 mg	In stock	$ 40.00
100 mg	In stock	$ 55.00
500 mg	In stock	$ 125.00
1 mL * 10 mM (in DMSO)	In stock	$ 39.00

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Purity: 99.81%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Targets&IC50

5-HT3 receptor:308 nM (IC50), D2 receptor:483 nM (IC50)

Synonyms	5-Chloro-2-methoxyprocainamide
Molecular Weight	299.8
Formula	C14H22ClN3O2
CAS No.	364-62-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (183.46 mM)

References and Literature

1. Navari RM, Nagy CK, Gray SE. The use of olanzapine versus metoclopramide for the treatment of breakthrough chemotherapy-induced nausea and vomiting in patients receiving highly emetogenic chemotherapy. Support Care Cancer. 2013 Jan 12. 2. Gutiérrez-Hermosillo H, Díaz de León-González E, Beltrán Santiago D et al. Metoclopramide as a risk factor for postprandial hyperglycemia in type 2 diabetes. Nutr Hosp. 2012 Jul-Aug;27(4):1267-71. 3. Ilan Matok, Sc.Pharm., Rafael Gorodischer, et al. The Safety of Metoclopramide Use in the First Trimester of Pregnancy. N Engl J Med 2009; 360:2528-2535. 4. DN Bateman, C Kahn, K Mashiter, DS Davies. Pharmacokinetic and concentration-effect studies with intravenous metoclopramide. British Journal of Clinical Pharmacology.1978,6(5): 401-407.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Inhibitor Library Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Anti-Neurodegenerative Disease Compound Library Drug Repurposing Compound Library Anti-Parkinson's Disease Compound Library Approved Drug Library Bioactive Compounds Library Max Human Metabolite Library

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Related compounds with same targets

Syrosingopine DOPEXAMINE L-745870 trihydrochloride Cariprazine Losulazine Flunarizine dihydrochloride Halopemide Veralipride

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Keywords

Metoclopramide 364-62-5 GPCR/G Protein Neuroscience 5-HT Receptor Dopamine Receptor gastro-oesophageal inhibit Serotonin Receptor 5-hydroxytryptamine Receptor 5-Chloro-2-methoxyprocainamide gastroparesis Inhibitor nausea reflux vomiting inhibitor

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