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Mitoxantrone dihydrochloride

Catalog No. T0158   CAS 70476-82-3
Synonyms: Mitoxantrone 2HCl, Mitoxantrone hydrochloride, NSC-301739, mitozantrone dihydrochloride

Mitoxantrone dihydrochloride (NSC-301739) is the hydrochloride salt of an anthracenedione antibiotic with antineoplastic activity. It is a type II topoisomerase inhibitor.

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Mitoxantrone dihydrochloride Chemical Structure
Mitoxantrone dihydrochloride, CAS 70476-82-3
Pack Size Availability Price/USD Quantity
50 mg In stock $ 50.00
100 mg In stock $ 72.00
500 mg In stock $ 183.00
1 mL * 10 mM (in DMSO) In stock $ 51.00
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Purity: 100%
Purity: 99.85%
Purity: 98.63%
Purity: 97.81%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Mitoxantrone dihydrochloride (NSC-301739) is the hydrochloride salt of an anthracenedione antibiotic with antineoplastic activity. It is a type II topoisomerase inhibitor.
Targets&IC50 kinase C (PKC):8.5 μM
In vitro In a murine air pouch model of inflammation, methotrexate demonstrated an inhibitory concentration 50 (IC50) of 0.08 mg/kg per week.
In vivo Methotrexate inhibits the de novo synthesis of purines and pyrimidines, the formation of polyamines, and the transmethylation reactions of DNA, RNA, phospholipids, and proteins. It suppresses the enzyme thymidylate synthase, leading to a deficiency of thymidylate inside cells, which ultimately results in antiproliferative cytotoxicity. Methotrexate enters cells either through active transport or facilitated diffusion and, once inside, polyglutamation inhibits dihydrofolate reductase, preventing the conversion of dihydrofolate to tetrahydrofolate.
Cell Research The human breast carcinoma cell lines MDA-MB-231 and MCF-7 are seeded in standard 96-well plates. One day after seeding, the culture medium is changed and replaced by medium containing different concentration of Mitoxantrone (10-5 to 5 μM) with or without DHA (30 μM) during 7 days. Viability of cells are measured as a whole by the tetrazolium salt assay[3].
Synonyms Mitoxantrone 2HCl, Mitoxantrone hydrochloride, NSC-301739, mitozantrone dihydrochloride
Molecular Weight 517.4
Formula C22H30Cl2N4O6
CAS No. 70476-82-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 38.8 mg/mL (75 mM)

H2O: 2.6 mg/mL (5 mM)

TargetMolReferences and Literature

1. Seitz M. Curr Opin Rheumatol, 1999, 11(3), 226-232. 2. Hirata S, et al. Arthritis Rheum, 1989, 32(9), 1065-1073. 3. Segal R, et al. Semin Arthritis Rheum, 1990, 20(3), 190-200. 4. Genestier L, et al. J Clin Invest, 1998, 102(2), 322-328. 5. Cronstein BN, et al. J Clin Invest, 1993, 92(6):2675-2682.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Anti-Cancer Clinical Compound Library Anti-Cancer Approved Drug Library Anti-Neurodegenerative Disease Compound Library Anti-Cancer Drug Library Drug Repurposing Compound Library Pediatric Drug Library Chemotherapy Drug Library Epigenetics Compound Library Antibiotics Library

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Keywords

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