Home Tools
Log in
Cart

Verapamil hydrochloride

Catalog No. T1010   CAS 152-11-4
Synonyms: Manidon, (±)-Verapamil hydrochlorid, Verapamil HCl, Calcan hydrochloride

Verapamil hydrochloride (Verapamil HCl) is a calcium channel blocker that is a class IV anti-arrhythmia agent.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Verapamil hydrochloride Chemical Structure
Verapamil hydrochloride, CAS 152-11-4
Pack Size Availability Price/USD Quantity
500 mg In stock $ 41.00
1 g In stock $ 48.00
1 mL * 10 mM (in DMSO) In stock $ 45.00
Bulk Inquiry
Get quote
Select Batch  
Purity: 99.98%
Purity: 99.91%
Purity: 99.79%
Purity: 98.7%
Contact us for more batch information
Biological Description
Chemical Properties
Storage & Solubility Information
Description Verapamil hydrochloride (Verapamil HCl) is a calcium channel blocker that is a class IV anti-arrhythmia agent.
Cell Research Verapamil is dissolved in DMSO and stored, and then diluted with appropriate media before use[1]. Cells (1×105) are treated with 10 nM Bortezomib and/or 70 μM Verapamil for 16 hours and incubated for another 4 hours with Alamar-Blue. Activity of the mitochondrial dehydrogenase results in conversion of the coloring, which is followed by measurement of the absorption using a spectrophotometer[1].
Synonyms Manidon, (±)-Verapamil hydrochlorid, Verapamil HCl, Calcan hydrochloride
Molecular Weight 491.06
Formula C27H39ClN2O4
CAS No. 152-11-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 24.6 mg/mL (50 mM)

H2O: 24.6 mg/mL (50 mM)

TargetMolReferences and Literature

1. Yanjiao X, et al. Drug Metab Pharmacokinet, 2013. 2. Zhou P, et al. PLoS One, 2013, 8(8), e71567. 3. Mao J Y, Su L X, Li D K, et al. The effects of UCP2 on autophagy through the AMPK signaling pathway in septic cardiomyopathy and the underlying mechanism[J]. Annals of Translational Medicine. 2021, 9(3).

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Drug Library Anti-Neurodegenerative Disease Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Clinical Compound Library Bioactive Compound Library NO PAINS Compound Library Anti-Hypertension Compound Library Drug Repurposing Compound Library FDA-Approved Drug Library Ion Channel Inhibitor Library

Related Products

Related compounds with same targets
Efonidipine hydrochloride monoethanolate Urolithin C SQ-31765 Nilvadipine Palonidipine β-Amino Acid Imagabalin Hydrochloride Verapamil Ethacrynic acid

TargetMolDose Conversion

You can also refer to dose conversion for different animals. More

TargetMol In vivo Formulation Calculator (Clear solution)

Step One: Enter information below
Dosage
mg/kg
Average weight of animals
g
Dosing volume per animal
ul
Number of animals
Step Two: Enter the in vivo formulation
% DMSO
%
% Tween 80
% ddH2O
Calculate Reset

TargetMolCalculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculation
Molecular Weight Calculator
=
X
X

Molarity Calculator allows you to calculate the

  • Mass of a compound required to prepare a solution of known volume and concentration
  • Volume of solution required to dissolve a compound of known mass to a desired concentration
  • Concentration of a solution resulting from a known mass of compound in a specific volume
See Example

An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
Press calculate
The answer of 19.713 mg appears in the Mass box

X
=
X

Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

See Example

An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
Press calculate
The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

=
/

Calculate the volume of solvent required to reconstitute your vial.

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial.
Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

g/mol

Enter the chemical formula of a compound to calculate its molar mass and elemental composition

Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

bottom

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Verapamil hydrochloride 152-11-4 Membrane transporter/Ion channel Metabolism Neuroscience Calcium Channel P450 P-gp Ca channels Verapamil inhibit Inhibitor Verapamil Hydrochloride Manidon pressure Pgp ABCB1 Verapamil hydrochlorid Ca2+ channels P-glycoprotein (±)-Verapamil hydrochlorid lysosomotropic Verapamil HCl MDR1 high Calcan hydrochloride (±)-Verapamil angina Palbociclib Cytochrome P450 Calcan Hydrochloride CD243 Cluster of differentiation 243 CYP3A4 Multidrug resistance protein 1 antiarrhythmic CYPs blood inhibitor

 

TargetMol