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Nebivolol hydrochloride
Nebivolol hydrochloride (R 065824 hydrochloride) is a cardioselective ADRENERGIC BETA-1 RECEPTOR ANTAGONIST (beta-blocker) that functions as a VASODILATOR through the endothelial L-arginine/ NITRIC OXIDE system. It is used to manage HYPERTENSION and chronic HEART FAILURE in elderly patients.
Catalog No. T0154Cas No. 152520-56-4
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Purity:100%
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Nebivolol hydrochloride
Catalog No. T0154Alias R-65824, R 065824 hydrochloride, Nebivolol HClCas No. 152520-56-4
Nebivolol hydrochloride (R 065824 hydrochloride) is a cardioselective ADRENERGIC BETA-1 RECEPTOR ANTAGONIST (beta-blocker) that functions as a VASODILATOR through the endothelial L-arginine/ NITRIC OXIDE system. It is used to manage HYPERTENSION and chronic HEART FAILURE in elderly patients.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | $43 | In Stock | |
| 25 mg | $63 | In Stock | |
| 50 mg | $97 | In Stock | |
| 100 mg | $166 | In Stock | |
| 200 mg | $282 | In Stock | |
| 500 mg | $488 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $38 | In Stock |
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CitedProduct Introduction
Bioactivity
Chemical Properties
| Description | Nebivolol hydrochloride (R 065824 hydrochloride) is a cardioselective ADRENERGIC BETA-1 RECEPTOR ANTAGONIST (beta-blocker) that functions as a VASODILATOR through the endothelial L-arginine/ NITRIC OXIDE system. It is used to manage HYPERTENSION and chronic HEART FAILURE in elderly patients. |
| Targets&IC50 | β1-adrenoceptor:0.8 nM |
| Cell Research | Cells are exposed to different concentrations of Nebivolol (10-7~10-5 M) for 1, 2, 4, 7 and 14 days. Cell proliferation is analyzed by bromodeoxyuridine (BrdU) incorporation, and cell apoptosis is detected by PI or annexin V staining.(Only for Reference) |
| Alias | R-65824, R 065824 hydrochloride, Nebivolol HCl |
| Molecular Weight | 441.9 |
| Formula | C22H25F2NO4·HCl |
| Cas No. | 152520-56-4 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: 4.4 mg/mL (10 mM) DMSO: 60 mg/mL (135.78 mM), Sonication is recommended.  | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords
R-065824 Hydrochlorideadrenergic blockingAdrenergic Receptorischemic heart diseaseR65824R 065824congestive heart failurecoronary artery diseaseR065824NebivololoralinhibithypertensionR 065824 HydrochlorideNebivolol hydrochlorideInhibitorR065824 HydrochlorideBeta ReceptorvasodilatorR 65824ApoptosisR-065824Nebivolol Hydrochloride
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