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Propantheline bromide

🥰Excellent
Catalog No. T1006Cas No. 50-34-0
Alias Pro-Banthine, Neopepulsan, Neometantyl

Propantheline bromide (Pro-Banthine) competitively antagonizes acetylcholine activity mediated by muscarinic receptors at neuroeffector sites on smooth muscle and exocrine gland cells. Propantheline Bromide is the bromide salt form of propantheline, a quaternary ammonium compound structurally related to belladonna alkaloids. An aspartic acid residue present in the N-terminal portion of the third transmembrane helix of the muscarinic receptor is believed to form an ionic bond with the tertiary or quaternary nitrogen of the antagonist. Antagonism leads to a reduction of exocrine glands secretions and to relax the bronchial muscle and reduce tone and motility of intestinal smooth muscle.

Propantheline bromide

Propantheline bromide

🥰Excellent
Purity: 98%
Catalog No. T1006Alias Pro-Banthine, Neopepulsan, NeometantylCas No. 50-34-0
Propantheline bromide (Pro-Banthine) competitively antagonizes acetylcholine activity mediated by muscarinic receptors at neuroeffector sites on smooth muscle and exocrine gland cells. Propantheline Bromide is the bromide salt form of propantheline, a quaternary ammonium compound structurally related to belladonna alkaloids. An aspartic acid residue present in the N-terminal portion of the third transmembrane helix of the muscarinic receptor is believed to form an ionic bond with the tertiary or quaternary nitrogen of the antagonist. Antagonism leads to a reduction of exocrine glands secretions and to relax the bronchial muscle and reduce tone and motility of intestinal smooth muscle.
Pack SizePriceAvailabilityQuantity
50 mg$33In Stock
100 mg$47In Stock
200 mg$68In Stock
500 mg$109In Stock
1 mL x 10 mM (in DMSO)$39In Stock
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Purity:98%
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Product Introduction

Bioactivity
Description
Propantheline bromide (Pro-Banthine) competitively antagonizes acetylcholine activity mediated by muscarinic receptors at neuroeffector sites on smooth muscle and exocrine gland cells. Propantheline Bromide is the bromide salt form of propantheline, a quaternary ammonium compound structurally related to belladonna alkaloids. An aspartic acid residue present in the N-terminal portion of the third transmembrane helix of the muscarinic receptor is believed to form an ionic bond with the tertiary or quaternary nitrogen of the antagonist. Antagonism leads to a reduction of exocrine glands secretions and to relax the bronchial muscle and reduce tone and motility of intestinal smooth muscle.
AliasPro-Banthine, Neopepulsan, Neometantyl
Chemical Properties
Molecular Weight448.4
FormulaC23H30BrNO3
Cas No.50-34-0
Smiles[Br-].CC(C)[N+](C)(CCOC(=O)C1c2ccccc2Oc2ccccc12)C(C)C
Relative Density.1.2916 g/cm3 (Estimated)
Storage & Solubility Information
Storagestore under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 50 mg/ml (111.51 mM), Sonication is recommended.
DMSO: 60 mg/mL (133.81 mM)
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM2.2302 mL11.1508 mL22.3015 mL111.5076 mL
5 mM0.4460 mL2.2302 mL4.4603 mL22.3015 mL
10 mM0.2230 mL1.1151 mL2.2302 mL11.1508 mL
20 mM0.1115 mL0.5575 mL1.1151 mL5.5754 mL
50 mM0.0446 mL0.2230 mL0.4460 mL2.2302 mL
100 mM0.0223 mL0.1115 mL0.2230 mL1.1151 mL

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