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Tyrosine Kinase/Adaptors IGF-1R

IGF-1R

The insulin-like growth factor 1 (IGF-1) receptor is a protein found on the surface of human cells. It is a transmembrane receptor that is activated by a hormone called insulin-like growth factor 1 (IGF-1) and by a related hormone called IGF-2. It belongs to the large class of tyrosine kinase receptors. This receptor mediates the effects of IGF-1, which is a polypeptide protein hormone similar in molecular structure to insulin. IGF-1 plays an important role in growth and continues to have anabolic effects in adults – meaning that it can induce hypertrophy of skeletal muscle and other target tissues. Mice lacking the IGF-1 receptor die late in development, and show a dramatic reduction in body mass, testifying to the strong growth-promoting effect of this receptor.
Cat No. product name
T1791 LDK378HOT Ceritinib (LDK378) is a specific ALK inhibitor (IC50: 0.2 nM).
T1918 TAE226 NVP-TAE226 is an effective FAK inhibitor (IC50: 5.5 nM) and most effective to Pyk2(IC50: 3.5 nM); 10- to 100-fold less effective against IGF-1R, InsR, c-Met, an...
T2085 PQ401 PQ401 suppresses autophosphorylation of IGF-1R domain(IC50<1 μM).
T2349 BMS-754807 Dual IGF-1R/InsR Inhibitor BMS-754807 is an oral small molecule inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (InsR) tyrosine...
T2642 PD173074 PD173074 is an effective FGFR1 inhibitor (IC50: 25 nM) and also inhibits VEGFR2 (IC50: 100-200 nM) in cell-free assays. The selectivity is higher ~1000-fold fo...
T2693 AG1024 AG-1024 (Tyrphostin) suppresses IGF-1R autophosphorylation(IC50=7 μM),and is less potent for IR(IC50=57 μM).
T3059 AP26113 Brigatinib is a excellently effective and specific ALK inhibitor( IC50 =0.6 nM).
T3079 GSK1838705A GSK1838705A is an effective IGF-1R inhibitor (IC50: 2.0 nM), modestly potent to IR (IC50: 1.6 nM) and ALK (IC50: 0.5 nM), respectively, and little inhibition to...
T3621 Brigatinib Brigatinib is a highly potent and selective ALK inhibitor.
T6003 GSK1904529A GSK1904529A is a specific inhibitor of IGF-1R (IC50=27 nM) and IR(IC50=25 nM) .
T6017 Linsitinib OSI-906 (Linsitinib) is an orally bioavailable small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) with potential antineoplastic acti...
T6057 URMC-099 URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM...
T6080 NVP-AEW541 NVP-AEW541, a potent inhibitor of IGF-1R(IC50=150 nM) and InsR(IC50=140 nM), exhibits excellent efficiency and specificity for IGF-1R in a cell-based assay.
T6419 BMS-536924 BMS-536924 is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM, modest activity for Mek, Fak, and Lck with very little activity for Akt1, MAPK1/...
T6932 PD168393 PD168393 is an irreversible EGFR inhibitor (IC50: 0.70 nM), irreversibly alkylate Cys-773; inactive against PKC, FGFR, PDGFR, and insulin.
T6943 Picropodophyllin Picropodophyllin (PPP) is a specific IGF-1R inhibitor (IC50: 1 nM). Picropodophyllin specifically inhibits the activity and downregulates the cellular expressio...
T4324 PQ401 hydrochloride (196868-63-0(free base)) PQ401 inhibits autophosphorylation of IGF-1R domain with IC50 of <1 μM.
T3S0027 Picropodophyllotoxin Picropodophyllin is a cyclolignan alkaloid found in the mayapple plant family (Podophyllum peltatum), and a small molecule inhibitor of the insulin-like growth ...
T6S1487 Ginsenoside Rg5 1. Ginsenoside Rg5 could be a beneficial agent for the treatment of Alzheimer's disease. 2. Ginsenoside Rg5 suppresses LPS-induced nitric oxide (NO) production ...
T6079 NVP-ADW742 NVP-ADW742 is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and...
T8221 INSULIN INSULIN is a polypeptide hormone that regulates the level of glucose.
T14142 AGL-2263 AGL-2263 is a blocker of insulin receptor (IR)
TN4675 Nortrachelogenin Nortrachelogenin is a novel agent for prostate cancer therapy with ability to inhibit Akt membrane localization and activity as well as the activation of growth...
LDK378 HOT
T1791CAS 1032900-25-6
Ceritinib (LDK378) is a specific ALK inhibitor (IC50: 0.2 nM).
TAE226
T1918CAS 761437-28-9
NVP-TAE226 is an effective FAK inhibitor (IC50: 5.5 nM) and most effective to Pyk2(IC50: 3.5 nM); 10- to 100-fold less effective against IGF-1R, InsR, c-Met, an...
PQ401
T2085CAS 196868-63-0
PQ401 suppresses autophosphorylation of IGF-1R domain(IC50<1 μM).
BMS-754807
T2349CAS 1001350-96-4
Dual IGF-1R/InsR Inhibitor BMS-754807 is an oral small molecule inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (InsR) tyrosine...
PD173074
T2642CAS 219580-11-7
PD173074 is an effective FGFR1 inhibitor (IC50: 25 nM) and also inhibits VEGFR2 (IC50: 100-200 nM) in cell-free assays. The selectivity is higher ~1000-fold fo...
AG1024
T2693CAS 65678-07-1
AG-1024 (Tyrphostin) suppresses IGF-1R autophosphorylation(IC50=7 μM),and is less potent for IR(IC50=57 μM).
AP26113
T3059CAS 1197958-12-5
Brigatinib is a excellently effective and specific ALK inhibitor( IC50 =0.6 nM).
GSK1838705A
T3079CAS 1116235-97-2
GSK1838705A is an effective IGF-1R inhibitor (IC50: 2.0 nM), modestly potent to IR (IC50: 1.6 nM) and ALK (IC50: 0.5 nM), respectively, and little inhibition to...
Brigatinib
T3621CAS 1197953-54-0
Brigatinib is a highly potent and selective ALK inhibitor.
GSK1904529A
T6003CAS 1089283-49-7
GSK1904529A is a specific inhibitor of IGF-1R (IC50=27 nM) and IR(IC50=25 nM) .
Linsitinib
T6017CAS 867160-71-2
OSI-906 (Linsitinib) is an orally bioavailable small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) with potential antineoplastic acti...
URMC-099
T6057CAS 1229582-33-5
URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM...
NVP-AEW541
T6080CAS 475489-16-8
NVP-AEW541, a potent inhibitor of IGF-1R(IC50=150 nM) and InsR(IC50=140 nM), exhibits excellent efficiency and specificity for IGF-1R in a cell-based assay.
BMS-536924
T6419CAS 468740-43-4
BMS-536924 is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM, modest activity for Mek, Fak, and Lck with very little activity for Akt1, MAPK1/...
PD168393
T6932CAS 194423-15-9
PD168393 is an irreversible EGFR inhibitor (IC50: 0.70 nM), irreversibly alkylate Cys-773; inactive against PKC, FGFR, PDGFR, and insulin.
Picropodophyllin
T6943CAS 477-47-4
Picropodophyllin (PPP) is a specific IGF-1R inhibitor (IC50: 1 nM). Picropodophyllin specifically inhibits the activity and downregulates the cellular expressio...
PQ401 hydrochloride (196868-63-0(free base))
T4324CAS T4324
PQ401 inhibits autophosphorylation of IGF-1R domain with IC50 of <1 μM.
Picropodophyllotoxin
T3S0027CAS 17434-18-3
Picropodophyllin is a cyclolignan alkaloid found in the mayapple plant family (Podophyllum peltatum), and a small molecule inhibitor of the insulin-like growth ...
Ginsenoside Rg5
T6S1487CAS 186763-78-0
1. Ginsenoside Rg5 could be a beneficial agent for the treatment of Alzheimer's disease. 2. Ginsenoside Rg5 suppresses LPS-induced nitric oxide (NO) production ...
NVP-ADW742
T6079CAS 475488-23-4
NVP-ADW742 is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and...
INSULIN
T8221CAS 11061-68-0
INSULIN is a polypeptide hormone that regulates the level of glucose.
AGL-2263
T14142CAS 638213-98-6
AGL-2263 is a blocker of insulin receptor (IR)
Nortrachelogenin
TN4675CAS 34444-37-6
Nortrachelogenin is a novel agent for prostate cancer therapy with ability to inhibit Akt membrane localization and activity as well as the activation of growth...