T1791 |
LDK378HOT |
Ceritinib (LDK378) is a specific ALK inhibitor (IC50: 0.2 nM). |
T1918 |
TAE226 |
NVP-TAE226 is an effective FAK inhibitor (IC50: 5.5 nM) and most effective to Pyk2(IC50: 3.5 nM); 10- to 100-fold less effective against IGF-1R, InsR, c-Met, an...
|
T2085 |
PQ401 |
PQ401 suppresses autophosphorylation of IGF-1R domain(IC50<1 μM). |
T2349 |
BMS-754807 |
Dual IGF-1R/InsR Inhibitor BMS-754807 is an oral small molecule inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (InsR) tyrosine...
|
T2642 |
PD173074 |
PD173074 is an effective FGFR1 inhibitor (IC50: 25 nM) and also inhibits VEGFR2 (IC50: 100-200 nM) in cell-free assays. The selectivity is higher ~1000-fold fo...
|
T2693 |
AG1024 |
AG-1024 (Tyrphostin) suppresses IGF-1R autophosphorylation(IC50=7 μM),and is less potent for IR(IC50=57 μM). |
T3059 |
AP26113 |
Brigatinib is a excellently effective and specific ALK inhibitor( IC50 =0.6 nM). |
T3079 |
GSK1838705A |
GSK1838705A is an effective IGF-1R inhibitor (IC50: 2.0 nM), modestly potent to IR (IC50: 1.6 nM) and ALK (IC50: 0.5 nM), respectively, and little inhibition to...
|
T3621 |
Brigatinib |
Brigatinib is a highly potent and selective ALK inhibitor. |
T6003 |
GSK1904529A |
GSK1904529A is a specific inhibitor of IGF-1R (IC50=27 nM) and IR(IC50=25 nM) . |
T6017 |
Linsitinib |
OSI-906 (Linsitinib) is an orally bioavailable small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) with potential antineoplastic acti...
|
T6057 |
URMC-099 |
URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM...
|
T6080 |
NVP-AEW541 |
NVP-AEW541, a potent inhibitor of IGF-1R(IC50=150 nM) and InsR(IC50=140 nM), exhibits excellent efficiency and specificity for IGF-1R in a cell-based assay. |
T6419 |
BMS-536924 |
BMS-536924 is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM, modest activity for Mek, Fak, and Lck with very little activity for Akt1, MAPK1/...
|
T6932 |
PD168393 |
PD168393 is an irreversible EGFR inhibitor (IC50: 0.70 nM), irreversibly alkylate Cys-773; inactive against PKC, FGFR, PDGFR, and insulin. |
T6943 |
Picropodophyllin |
Picropodophyllin (PPP) is a specific IGF-1R inhibitor (IC50: 1 nM). Picropodophyllin specifically inhibits the activity and downregulates the cellular expressio...
|
T4324 |
PQ401 hydrochloride (196868-63-0(free base)) |
PQ401 inhibits autophosphorylation of IGF-1R domain with IC50 of <1 μM. |
T3S0027 |
Picropodophyllotoxin |
Picropodophyllin is a cyclolignan alkaloid found in the mayapple plant family (Podophyllum peltatum), and a small molecule inhibitor of the insulin-like growth ...
|
T6S1487 |
Ginsenoside Rg5 |
1. Ginsenoside Rg5 could be a beneficial agent for the treatment of Alzheimer's disease. 2. Ginsenoside Rg5 suppresses LPS-induced nitric oxide (NO) production ...
|
T6079 |
NVP-ADW742 |
NVP-ADW742 is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and...
|
T8221 |
INSULIN |
INSULIN is a polypeptide hormone that regulates the level of glucose. |
T14142 |
AGL-2263 |
AGL-2263 is a blocker of insulin receptor (IR) |
TN4675 |
Nortrachelogenin |
Nortrachelogenin is a novel agent for prostate cancer therapy with ability to inhibit Akt membrane localization and activity as well as the activation of growth...
|
TP1125 |
Insulin(cattle) |
Insulin cattle (Insulin from bovine pancreas) is a two-chain polypeptide hormone produced in vivo in the pancreatic β cells。It has often been used as growth...
|