Autophagy

Autophagy is the natural, regulated mechanism of the cell that removes unnecessary or disfunctional components. It allows the orderly degradation and recycling of cellular components. Three forms of autophagy are commonly described: macroautophagy, microautophagy, and chaperone-mediated autophagy (CMA). In macroautophagy, expendable cytoplasmic constituents are targeted and isolated from the rest of the cell within a double-membraned vesicle known as an autophagosome, which, in time, fuses with an available lysosome, bringing its specialty process of waste management and disposal; and eventually the contents of the vesicle (now called an autolysosome) are degraded and recycled.

Cat. No.	Product name	CAS No.	Purity
T1637	Deferoxamine Mesylate	138-14-7	99.8%
T1637	Deferoxamine Mesylate (DFOM) is an iron chelator and iron death inhibitor. Deferoxamine Mesylate binds free iron into a stable complex and reduces iron accumulat...
T0147	Clemastine fumarate	14976-57-9	99.8%
T0147	Clemastine fumarate (Meclastine (fumarate)) is a synthetic ethanolamine with anticholinergic, sedative, and histamine H1 antagonistic properties.
T11741	KAN0438757	1451255-59-6	99.8%
T11741	KAN0438757 is a selective and potent inhibitor of the metabolic kinase PFKFB3 with an IC50 of 0.19 μM.
T11844	LG-100064	153559-46-7	99.79%
T11844	LG-100064 is an agonist of retinoid-X-receptor (RXR)(EC50s of 330 nM, 200 nM, and 260 nM for RXRα, RXRβ and RXRγ)
T6646	Rosiglitazone hydrochloride	302543-62-0	99.79%
T6646	Rosiglitazone hydrochloride (BRL-49653 HCl) is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells.
T2S2362	Dehydrocorydaline nitrate	13005-09-9	99.79%
T2S2362	1. Dehydrocorydaline(DHC) not only inhibits antibody-mediated allergic reactions but also influences cell-mediated allergic reactions, and the inhibitory effect ...
T12831L	SAR405	1523406-39-4	99.79%
T12831L	SAR-405 is a potent and selective PIK3C3/Vps34 inhibitor (IC50:1.2 nM; Kd:1.5 nM) that prevents autophagy and synergizes with MTOR inhibition in tumor cells. SAR...
T3354	BIA 10-2474	1233855-46-3	99.79%
T3354	BIA 10-2474 is a long-acting reversible inhibitor of fatty acid amide hydrolase (FAAH) that increases levels of the neurotransmitter anandamide in the central ne...
T2921	Sinomenine hydrochloride	6080-33-7	99.79%
T2921	Sinomenine hydrochloride (Kukoline hydrochloride) is extracted from Sinomenium Acutum Rehderett Wilson.
T7886	Nidufexor	1773489-72-7	99.79%
T7886	Nidufexor is an agonist for the farnesoid X receptor (FXR).
T3952	TPEN	16858-02-9	99.79%
T3952	TPEN (TPEDA) is a specific cell-permeable heavy metal chelator.
T72039	CLK1-IN-3	2922550-28-3	99.79%
T72039	Clk1-in-3 is a + selective and highly potent sexual Clk1 inhibitor with an IC50 of 5 nM and 300 pairs higher affinity than Dyrk1A. CLK1-IN-3 also showed highly e...
T1659	Melatonin	73-31-4	99.79%
T1659	Melatonin (Melatonine) is a biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion increases in...
T2527	Ulipristal acetate	126784-99-4	99.79%
T2527	Ulipristal acetate (CDB-2914) is an orally bioavailable, acetate salt of ulipristal, a selective progesterone receptor modulator with anti-progesterone activity....
T0097	MRT67307	1190378-57-4	99.79%
T0097	Through its effects on ULK1 and ULK2, MRT67307 blocks autophagy. MRT67307 prevents the phosphorylation of IRF3 and the production of IFN-β and increases toll-lik...
T19857	Glyphosate	1071-83-6	99.79%
T19857	Glyphosate (Atila) is an herbicide. It also is a possible carcinogen to humans.
T2326	Tolvaptan	150683-30-0	99.78%
T2326	Tolvaptan (OPC-41061) is an orally bioavailable, selective, arginine vasopressin receptor 2 (V2, AVPR2) antagonist that can be used to treat hyponatremia.
T7586	Trifarotene	895542-09-3	99.78%
T7586	Trifarotene (CD5789) is a potent and selective RARγ agonist with 65-fold and 16-fold selectivitiy for the RARγ (EC50=7.7 nM) over RARα (EC50=500 nM) and RARβ (EC...
T0209	Loperamide hydrochloride	34552-83-5	99.78%
T0209	Loperamide hydrochloride (ADL 2-1294) is a synthetic, piperidine derivative and opioid agonist with antidiarrheal activity.
T6858	Hydroxyprogesterone caproate	630-56-8	99.78%
T6858	Hydroxyprogesterone caproate (Delalutin) is a synthetic progestational agent. It binds to and activates nuclear progesterone receptors in the reproductive system...