catl-2

SARS-CoV-2 Mpro-IN-5 is a dual inhibitor targeting Main Protease (M Pro) and Cathepsin L (CatL) with IC50 values of 1800 nM and 145 nM, respectively. This compound demonstrates antiviral activity by inhibiting SARS-CoV-2 replication in hACE2 expressing A549 cells, with an IC50 value of 14.7 nM.

SARS-CoV-2 Mpro-IN-4 is a dual inhibitor targeting Main Protease (M Pro) and Cathepsin L (CatL), exhibiting inhibition concentrations (IC50) of 900 nM and 60 nM, respectively. It demonstrates antiviral activity by effectively blocking SARS-CoV2 replication in hACE2-expressing A549 cells with an IC50 value of 8.2 nM.