compound 35

Compounds 35 are superior inhibitors of Ebola (Mayinga) and Marburg (Angola) infectious viruses.

Compound Fr12380 is a useful organic compound for research related to life sciences. The catalog number is Fr12380 and the CAS number is 3622-35-3.

Questiomycin A derivatives 22 is a useful organic compound for research related to life sciences. The catalog number is T67721 and the CAS number is 1807725-35-4.

mTOR inhibitor 11 is a useful organic compound for research related to life sciences. The catalog number is T9309 and the CAS number is 1195785-35-3.

CP-609754 (LNK-754) is a potent and reversible farnesyltransferase inhibitor with potential anticancer activity. It inhibits farnesylation of recombinant human H-Ras (IC50=0.57 ng mL) and K-Ras (IC50=46 ng mL)[1]. In 3T3 H-ras (61L)-transfected cell lines, CP-609754 exhibits a slow on off rate, inhibiting mutant H-Ras farnesylation with an IC50 of 1.72 ng mL[1]. The compound is competitive for the prenyl acceptor (H-Ras protein) and noncompetitive for the prenyl donor farnesyl PPI, selectively inhibiting farnesylation of both H- and K-Ras proteins in 3T3 transfectants[1]. In vivo, CP-609754 shows antitumor activity against 3T3 H-ras (61L) tumors, with tumor regression achieved at 100 mg kg twice daily and an ED50 for tumor growth inhibition at 28 mg kg[1]. Continuous i.p. infusion of CP-609754 inhibits tumor growth by over 50% and reduces tumor farnesyltransferase activity by over 30% when plasma concentration is maintained above 118 ng mL[1]. [1]. Stacy L Moulder, et al. A phase I open label study of the farnesyltransferase inhibitor CP-609,754 in patients with advanced malignant tumors. Clin Cancer Res. 2004 Nov 1;10(21):7127-35.

Biotinylated A8-35 is a useful organic compound for research related to life sciences. The catalog number is TF0054 and the CAS number is 1423685-21-5.

Phenyl hydrogen ((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate is a useful organic compound for research related to life sciences. The catalog number is T67229 and the CAS number is 379270-35-6.

Nepadutant is a useful organic compound for research related to life sciences. The catalog number is T71693 and the CAS number is 183747-35-5.

Ganoderitriol M is a useful organic compound for research related to life sciences. The catalog number is T126126 and the CAS number is 1265906-35-1.

Fruquintinib-d3 is a deuterated compound of Fruquintinib. Fruquintinib has a CAS number of 1194506-26-7. Fruquintinib is an orally available, small molecule inhibitor of vascular endothelial growth factor receptors (VEGFRs), with potential anti-angiogenic and antineoplastic activities.

AChE-IN-35 (compound 5g) is an acetylcholinesterase inhibitor with an IC50 value of 5.88 μM [1].

PI3K-IN-35 (Compound 6l) is a highly selective inhibitor of PI3K, targeting PI3K-α (IC50: 13.98 μM), PI3K-β (IC50: 7.22 μM), and PI3K-δ (IC50: 10.94 μM). It blocks the cell cycle in the G2 M phase and induces apoptosis, making it useful for studying leukemia.

LmCPB-IN-1 (compound 35) is a highly effective and reversible covalent inhibitor of Leishmania mexicana cysteine protease B (LmCPB), exhibiting a strong binding affinity with a pK i value of 9.7 [1].

HIV-1 inhibitor-16 (compound 7a) is a potent HIV-1 inhibitor with an EC50 of 1.3 nM against wild-type HIV-1, and exhibits inhibitory activity against HIV-1 K103N, E138K, Y181C, and L100I strains with EC50s of 5.4 nM, 9.2 nM, 22 nM, and 35 nM, respectively. It demonstrates good solubility, hepatic microsomal stability, and lacks significant CYP enzyme inhibitory activity or acute toxicity.

HDAC-IN-35 (Compound 14) is a potent and selective inhibitor of VEGFR-2 and HDAC, exhibiting IC50 values of 13.2 μM for VEGFR-2 and 0.166 μM for HDAC6.

5-HT1A antagonist 1 (compound 6f) is a potent and selective 5-HT1A receptor antagonist (Ki: 35 nM) and can be utilized in the study of central nervous system disorders.

(Met(O)35)-Amyloid β-Protein (1-42) is the oxidized form of Methionine 35 in Aβ42, capable of producing an oligomer size distribution similar to Aβ40. This compound is utilized in Alzheimer’s disease (AD) research [1].

TRAP1-IN-1 (compound 35) is a potent, selective TRAP1 inhibitor affecting the mitochondrial variant of Hsp90. It exhibits over 250-fold greater selectivity for TRAP1 compared to Grp94, destabilizes TRAP1 tetramers, and promotes the degradation of TRAP1 client proteins. Additionally, TRAP1-IN-1 impedes mitochondrial complex I activity involved in oxidative phosphorylation (OXPHOS), compromises the mitochondrial membrane potential, and augments glycolytic metabolism [1].

Compound 35 (PAP-IN-2) is a purple acid phosphatase (PAP) inhibitor with an inhibition constant (Ki) of 186 nM, potentially useful in the development of anti-osteoporotic compounds [1].

eeAChE eqBuChE-IN-1 (compound 3F) serves as a reversible dual inhibitor of eeAChE eqBuChE, exhibiting IC50 values of 1.3 μM and 0.81 μM, respectively. In addition, this compound demonstrates anti-inflammatory properties and provides neuroprotective effects against Aβ25-35-induced injury in PC12 cells [1].

STING agonist-35 (Compound 1a) is an agonist for stimulator of interferon genes (STING), activating wild type STING and mutated type STING (R232H) at rates of 99% and 92%, respectively. It is a potent payload for ADC [1].

Gefitinib-d6 is a deuterated compound of Gefitinib. Gefitinib has a CAS number of 184475-35-2. Gefitinib is an EGFR tyrosine kinase inhibitor and can inhibit Tyr1173, Tyr992, Tyr1173 and Tyr992 (IC50s: 37/37/26/57 nM).

Saccatoside is a useful organic compound for research related to life sciences. The catalog number is T124080 and the CAS number is 85819-35-8.

Dactylorhin B is an active compound isolated from Coeloglossum Viride. Dactylorhin B reduces the toxic effects of β -amyloid fragments (25-35) on neuron cells and isolated rat brain mitochondria, which play an important role in neurodegenerative diseases.

Antibiotic LL-D253gamma is a useful organic compound for research related to life sciences. The catalog number is T125005 and the CAS number is 34288-35-2.

4-Hydroxyphthalic acid is a useful organic compound for research related to life sciences. The catalog number is T67158 and the CAS number is 610-35-5.

HPK1-IN-35 is a potent, selective inhibitor of HPK1, demonstrating an IC50 value of 3.5 nM. This compound reduces p-SLP76 expression and facilitates the secretion of IL-2 [1].

VEGFR-2-IN-35 (compound 7) is a potent VEGFR-2 inhibitor with an IC50 of 37 nM, and it also inhibits MCF-7 and HCT 116 cancer cell lines with IC50 values of 10.56 μM and 7.07 μM, respectively [1].

Antiviral agent 35 (compound 4d) is a potent oral inhibitor of the influenza virus, targeting early stages of viral replication. It suppresses influenza-induced ROS accumulation, autophagy, apoptosis, and the inflammatory response mediated by the RIG-1 pathway in a mouse model of pulmonary infection. Its cytotoxicity is minimal in MDCK cells, with a CC50 greater than 800 μM, and it has anti-H1N1 (A Weiss 43) activity with an EC50 of 2.28 μM [1].

COX-2-IN-35 (compound 7) is a selective COX-2 inhibitor with anti-inflammatory activity, exhibiting an inhibitory concentration (IC 50) of 4.37 nM [1].

Antitumor agent-54 (Compound C11) is a 14-3-3η protein inhibitor (KD: 35 μM). antitumor agent-54 inhibits several typical human hepatocellular carcinoma cell lines. antitumor agent-54 blocks the cell cycle in the G1-S phase and induces apoptosis, showing good metabolic stability. It exhibits good metabolic stability.

GSK-3β inhibitor 9 (Compound 9b) is a highly selective, orally bioavailable and potent GSK-3β inhibitor with the IC 50 of 35 nM. GSK-3β inhibitor 9 exhibits good pharmacokinetic profiles including favorable BBB penetration. GSK-3β inhibitor 9 is able to be used for the research of Alzheimer’s disease [1].

N6-Bz-5'-O-DMTr-2'-O-hexadecanyl adenosine 3'-CED phosphoramidite, with catalog number TNU1652 and CAS number 2382942-35-8, is an essential organic compound used in life sciences research.

N2,N2-Dimethylamino-6-deamino adenosine, with catalog number TNU1644 and CAS number 105208-35-3, is a valuable organic compound for life sciences research.

KRAS G12C Inhibitor 35 is a potent suppressor of KRAS G12C, targeting a crucial member of the Ras protein family which significantly impacts cellular growth and development. This compound holds promise for investigating cancer driven by KRAS G12C mutations.

FINDY, an inhibitor selective for the folding intermediate of DYRK1A, effectively blocks Ser97 autophosphorylation, exhibiting an IC50 of 35 μM. This compound is utilized in neurological disorder research.

Diprovocim-X (compound 35), a robust TLR1/TLR2 (toll-like receptor 1/2) agonist, exhibits EC 50 values of 0.14 nM for hTLR1/TLR2 and 0.75 nM for mTLR1/TLR2. As a potent in vivo adjuvant in mice, it effectively stimulates the adaptive immune response [1].

IFN-γ Antagonist 1 (AYCRDGKIGPPKLDIRKEEKQI), an interferon γ (IFN γ) antagonist, effectively inhibits IFN-γ induced HLR/DR antigen expression in Colon 205 cells, demonstrating an IC50 of approximately 35 μM. This compound shows promise for applications in immune regulation [1].

ZLMT-12 (compound 35) is a tacrine derivative and a potent inhibitor of CDK2 (IC50: 0.011 μM) and CDK9 (IC50: 0.002 μM). ZLMT-12 weakly inhibits AChE (IC50: 19.023 μM) and BuChE (IC50: 2.768 μM). ZLMT-12 has anti-proliferative activity and low cytotoxicity. ZLMT-12 blocks the cell cycle in S-phase and G2/M-phase and induces apoptosis.

IFN-γ Antagonist 1 (AYCRDGKIGPPKLDIRKEEKQI) acetate, an interferon γ (IFN γ) antagonist, effectively inhibits the expression of HLR DR antigen in Colon 205 cells induced by IFN-γ, with an IC50 of approximately 35 μM. This compound holds promise for applications in immune regulation [1].

Ciwujianoside D1 is a useful organic compound for research related to life sciences. The catalog number is T126335 and the CAS number is 114912-35-5.

(S)-2-Amino-2-methyl-3-phenylpropanoic acid, catalog number T65082 and CAS number 23239-35-2, is a valuable organic compound for life sciences research.

SulfaMethoxypyridazine-d3 is a deuterated compound of SulfaMethoxypyridazine. SulfaMethoxypyridazine has a CAS number of 80-35-3. Sulfamethoxypyridazine is a sulfanilamide antibacterial agent.

Bonaniol A is a useful organic compound for research related to life sciences. The catalog number is T123836 and the CAS number is 96917-35-0.

4,5,6,7-Tetrahydro-2H-isoindole is a useful organic compound for research related to life sciences. The catalog number is T66325 and the CAS number is 51649-35-5.

URAT1 inhibitor 6 (Compound 1h), with an IC50 of 35 nM for hURAT1, demonstrates 200-fold and 8-fold greater potency compared to Lesinurad and Benzbromarone, respectively. This compound is utilized in the study of inflammation [1].

Estrogen receptor α antagonist 1 (compound 35) is a highly selective antagonist of estrogen receptor α, demonstrating an IC50 of 0.02 μM against this receptor and also affecting estrogen receptor β. This compound is utilized in tumor research.

(S)-tert-Butyl 2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-hydroxypropanoate is a useful organic compound for research related to life sciences. The catalog number is T65351 and the CAS number is 110797-35-8.

Lp-PLA2-IN-5 is a potent lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor and an inhibitor of platelet-activating factor acetylhydrolase (PAF-AH), a phospholipase A2 involved in lipoprotein lipid or phospholipid hydrolysis. Lp-PLA2-IN-5 (Compound 35) may have potential applications in studying diseases linked to Lp-PLA2 activity, including Alzheimer's disease and atherosclerosis.

Fellutanine A is a useful organic compound for research related to life sciences. The catalog number is T129801 and the CAS number is 175414-35-4.