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HPK1-IN-35 is a potent, selective inhibitor of HPK1, demonstrating an IC50 value of 3.5 nM. This compound reduces p-SLP76 expression and facilitates the secretion of IL-2 [1].
Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,520 | 8-10 weeks | |
50 mg | $1,980 | 8-10 weeks | |
100 mg | $2,500 | 8-10 weeks |
Description | HPK1-IN-35 is a potent, selective inhibitor of HPK1, demonstrating an IC50 value of 3.5 nM. This compound reduces p-SLP76 expression and facilitates the secretion of IL-2 [1]. |
Targets&IC50 | HPK1:3.5 nM |
In vitro | HPK1-IN-35 (compound 31) reduces anti-CD3 antibody (1 µg/mL)-stimulated p-SLP76 expression dose-dependently at concentrations of 0.1, 0.3, 1, and 3 µM after 1 hour of treatment [1]. Furthermore, HPK1-IN-35 enhances IL-2 secretion from Jurkat cells in a dose-dependent manner within the range of 0-10 µM over 24 hours, with an EC50 value of 1.19 µM [1]. |
Molecular Weight | 584.69 |
Formula | C30H32N8O3S |
Cas No. | 2935903-77-6 |
Storage | Shipping with blue ice. |
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