h2ax

h-NTPDase-IN-2 is a broad-spectrum NTPDase inhibitor that inhibits multiple h-NTPDas isoforms.

OfChi-h-IN-2 (compound TQ19) is a potent inhibitor of OfChi-h, exhibiting a K i of 0.33 μM, and significantly impairs the growth and development of Ostrinia nubilalis larvae. This compound is relevant for research in agricultural insecticides [1].

pFR-pNA, chromogenic substrate for the determination of plasma kallikrein-like activity. CAS Number (net): 64816-19-9.

H-Phe(2-Me)-OH is a useful organic compound for research related to life sciences and the catalog number is T66208.

1,7'-Dimethyl-2'-propyl-1H,1'H-2,5'-bibenzo[d]imidazole is a useful organic compound for research related to life sciences. The catalog number is T65771 and the CAS number is 152628-02-9.

H-DL-Phg(2-Cl)-OH is a useful organic compound for research related to life sciences. The catalog number is T64955 and the CAS number is 88744-36-9.

H-Phe(2-F)-OH is a useful organic compound for research related to life sciences. The catalog number is T67305 and the CAS number is 19883-78-4.

H-Val-Pro-Pro-OH(TFA), a proline peptide derivative from milk, is an ACE inhibitor with IC50 of 9 M.

H-Phe(2-Cl)-OH is a useful organic compound for research related to life sciences. The catalog number is T65656 and the CAS number is 103616-89-3.

(H-Tyr-Ile-Asn-Leu-Cys-Thr-Arg-Nva-Arg-Tyr-NH2)2 trifluoroacetate is a useful organic compound for research related to life sciences and the catalog number is T64688.

H-D-Phe(2-Cl)-OH is a useful organic compound for research related to life sciences. The catalog number is T66206 and the CAS number is 80126-50-7.

(2'R,7R,8R,10S,13S,14S)-Methyl 10,13-dimethyl-3,5'-dioxo-1,2,3,4',5',6,7,8,10,12,13,14,15,16-tetradecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-7-carboxylate is a useful organic compound for research related to life sciences. The catalog number is T65404 and the CAS number is 95716-70-4.

H-D-2-Pal-OH is an amino acid derivative and has a wide range of applications in life science related research.

H-2-Pal-OH is an amino acid derivative and has a wide range of applications in life science related research.

BMH-21, a small molecule DNA intercalator, binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription and not affects phosphorylation of H2AX.

RHPS4 (RHPS 4 methosulfate) is a potent inhibitor of Telomerase at submicromolar.

Prexasertib dihydrochloride (LY2606368) is an ATP-competitive CHK1 inhibitor (Ki: 0.9 nmol/L). in the cell-free assay, its IC50 values are 8 nM and 9 nM for CHK2 and RSK, respectively.

Antitumor agent-37 exhibits potent anti-proliferative and anti-metastatic effects. antitumor agent-37 induces severe DNA damage, leading to high expression of γ-H2AX and p53. antitumor agent-37 induces apoptosis by exploiting the mitochondrial apoptosis pathway Bcl-2/Bax/caspase3. Antitumor agent-37 inhibits PD-L1 expression, increases CD3+ and CD8+ T-infiltrating cells in tumour tissue and significantly improves the immune response.

Antitumor agent-36 exhibits strong anti-proliferative and anti-metastasis capabilities, causing significant DNA damage that results in elevated levels of γ-H2AX and p53. It promotes tumor cell apoptosis via the mitochondrial apoptotic pathway involving Bcl-2/Bax/caspase3 and enhances immune response by inhibiting PD-L1 expression, thereby increasing CD3+ and CD8+ T cell infiltration in tumor tissues [1].

SFOM-0046 is an anticancer agent. SFOM-0046 arrests the cell cycle in S-phase and causes DNA replication stress, resulting in the phosphorylation of H2AX into gamma-H2AX.

Rigosertib sodium (ON-01910), a non-ATP-competitive inhibitor of PLK1(IC50=9 nM), exhibits 30-fold higher specificity activity over Plk2 and no effect on Plk3.

OTS186935 hydrochloride is a potent inhibitor of the protein methyltransferase SUV39H2 (IC50: 6.49 nM). oTS186935 hydrochloride significantly inhibited tumor growth in a mouse xenograft model with no apparent toxicity. oTS193320 OTS193320 hydrochloride was able to modulate γ-H2AX production in cancer cells.

Rigosertib (ON-01910) is a selective and non-ATP-competitive inhibitor of PLK1 (IC50: 9 nM). Rigosertib is a multi-kinase inhibitor and a selective anti-cancer agent, which induces apoptosis by inhibition of the PI3 kinase/Akt pathway, promotes the phosphorylation of histone H2AX and induces G2/M arrest in the cell cycle.

S39625, an E-ring camptothecin keto analogue, is a stable, potent, and selective topoisomerase I inhibitor without being substrates of drug efflux transporters. Nanomolar concentrations of S39625 induces intense and persistent histone gamma-H2AX. The chem

OTS193320, an imidazopyridine compound, acts as an inhibitor of SUV39H2 methyltransferase activity. It effectively reduces global histone H3 lysine 9 tri-methylation levels in breast cancer cells, promoting apoptotic cell death. When combined with Doxorubicin (DOX; HY-15142A), OTS193320 enhances the reduction of γ-H2AX levels and decreases cancer cell viability more significantly than when either agent is used alone.

Prexasertib (LY2606368) is an inhibitor of checkpoint kinase 1 (chk1) with potential antineoplastic activity.