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By Target- Autophagy
- Mitophagy(1)
- p38 MAPK(1)
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Results for "
rwj-64809
" in TargetMol Product Catalog- Inhibitors & Agonists2
Adezmapimod
Cited
T1764152121-47-6
Adezmapimod (SB 203580) is a selective, ATP-competitive p38 MAPK inhibitor (IC50=0.3-0.5 μM) that activates autophagy and mitochondrial autophagy, with more than 100-fold higher selectivity over PKB, LCK, and GSK-3β.
- $30
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QTY
CitedSB 203580 hydrochloride
T21675869185-85-3
Adezmapimod (SB 203580) hydrochloride is a selective ATP-competitive inhibitor of p38 MAPK, with IC50 values of 50 nM for SAPK2a p38 and 500 nM for SAPK2b p38β2. This compound also inhibits LCK, GSK3β, and PKBα with IC50 values 100-500 times higher than those for SAPK2a p38. Additionally, Adezmapimod hydrochloride acts as an activator of autophagy and mitophagy [1].
- $36
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