14,15leukotriene d4

14,15-Leukotriene D4 (14,15-LTD4) is a member of an alternate class of LTs synthesized by a pathway involving the dual actions of 15- and 12-lipoxygenases (15- and 12-LOs) on arachidonic acid via 15-HpETE and 14,15-LTA4 intermediates. 14,15-LTD4 is classified as an eoxin (EXD4), because it is formed mostly by eosinophils. However, mast cells and nasal polyps can synthesize 14,15-LTD4 as well. Little is known about the physiological actions of 14,15-LTD4. It has weak contractile activity on both guinea pig ileum and pulmonary parenchyma in contrast to the effects of 5-LO-derived LTs. However, in an in vitro permeability assay, 14,15-LTD4 can increase vascular permeability of human endothelial cell monolayers, with similar potency to that of 5-LO-derived LTs, resulting in plasma leakage, a hallmark of inflammation.

Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside can moderately inhibit α-amylase activity, with the IC50 value of 0.03 umol/ml.

d[Cha4]-AVP acetate is a potent and selective human vasopressin V1B receptor agonist (Ki values are 1.2, 151, 240 and 750 nM for V1B, V1A, Oxytocin and V2 receptors respectively). Stimulates ACTH and corticosterone secretion and exhibits negligible vasopr

1-{1H-pyrrolo[2,3-d]pyrimidin-4-yl}piperazine dihydrochloride (1-PPZ-DHC) is a compound used as a molecular structural unit. It is an analog of the natural product piperazine and has a wide range of biological activities, including anti-inflammatory, anti-tumor and antibacterial activities. It has also been studied for the treatment of neurological disorders such as Alzheimer's and Parkinson's.

4-Chlorothieno[3,2-d]pyrimidine is a useful organic compound for research related to life sciences. The catalog number is T7256 and the CAS number is 16269-66-2.

2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidine serves as an intermediate.

7-benzyl-5,6-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine is a inhibitor of Hepatitis C Virus(HCV).

4-Amino-5-Bromopyrrolo[2,3-D]Pyrimidine (5-bromo-1H-pyrrolo[2,3-d]pyrimidin-4-amine) is a marine derived natural products found in Echinodictyum sp.

5-phenylthieno[2,3-d]pyrimidin-4-amine is a heterocyclic compound. It inhibits a variety of enzymes such as kinases and phosphodiesterases and has potential therapeutic activity for a variety of diseases.

4-Fluoro-D-phenylalanine HCl (4-Fluorophenylalanine) is an amino acid salt.

Epipinoresinol-4'-O-β-D-glucoside (Simplocosin) is a glucoside compound[1].

2H-Naphth[2′,1′:4,5]indeno[1,2-d][1,3]dioxole, pregn-4-ene-3,20-dione deriv showed high local anti-inflammatory potency and high lung selectivity when tested on Sprague Dawley rats.

3-(2,6-dichlorophenyl)-1-methyl-7-(methylsulfanyl)-1H,2H,3H,4H-pyrimido[4,5-d][1,3]diazin-4-one is a compound that has been extensively investigated for the treatment of a variety of disorders including tumors, Alzheimer's and Parkinson's diseases, anti-inflammatory drugs, and analgesic agents.

1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)thieno[3,2-d]pyrimidin-2-yl)phenyl)-3-(pyridin-4-yl)urea is a useful organic compound for research related to life sciences. The catalog number is T67700 and the CAS number is 1144075-47-7.

Pyrazinecarboxamide, 3,4-dihydro-4-[5-O-[hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl]-β-D-ribofuranosyl]-3-oxo- is a useful organic compound for research related to life sciences. The catalog number is TNU0422L and the CAS number is 356783-01-2.This compound is unstable in powder form and other related salt forms are recommended.

D-erythrose 4-sodium phosphate is the sodium phosphate of the monosaccharide erythrose. Erythritol is actually converted to D-erythrose 4-phosphate involving three isomerases.

[D-Pro4,D-Trp7,9,10] Substance P (4-11) serves as a potent antagonist of the tachykinin family of neuropeptides [1].

Cimifugin 4'-O-beta-D-glucopyranoside is a natural product

3-O-Methylquercetin 4',7-di-β-D-glucopyranoside, a flavonoside, is isolated from Ophioglossum pedunculosum [1].

4-Methylumbelliferyl β-D-N,N'-diacetylchitobioside (4-μU-(GlcNAc)2) is a fluorogenic substrate for chitinases and chitobiosidases. 4-μU-(GlcNAc)2 is cleaved by chitinases and chitobiosidases to release the fluorescent moiety 4-μU. 4-μU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high pH (7.12-10.3), respectively, and an emission maximum ranging from 445 to 455 nm, increasing as pH decreases.

(+)-Pinoresinol monomethyl ether 4-O-β-D-glucoside is a natural product.

Quinovic acid 3-O-(3',4'-O-isopropylidene)-beta-D-fucopyranoside is a natural product for research related to life sciences. The catalog number is TN4885 and the CAS number is 182132-59-8.

2-Acetamido-2,4-dideoxy-4-fluoro-α-D-glucopyranose (compound 13) functions as a potent hepatic glycosaminoglycan biosynthesis inhibitor.

4-Nitrophenyl β-D-cellotrioside is a chromogenic substrate for endoglucanases and cellobiohydrolases. Hydrolysis of this substrate by these enzymes liberates 4-nitrophenol, which generates a yellow color that is measured by monitoring absorbance at 405 nm.

D-erythritol 4-phosphate is a phosphorylated component isolated from the hydrolysate.

D-myo-Inositol-4-phosphate (Ins(4)P1) is a member of the inositol phosphate (InsP) molecular family that play critical roles as small, soluble second messengers in the transmission of cellular signals. The most studied InsP, Ins(1,4,5)P3, is a second messenger produced in cells by phospholipase C (PLC)-mediated hydrolysis of phosphatidylinositol-4,5-diphosphate. Binding of Ins(1,4,5)P3 to its receptor on the endoplasmic reticulum results in opening of the calcium channels and an increase in intracellular calcium. Ins(4)P1 can be formed by dephosphorylation of Ins(1,4)P2 by inositol polyphosphate 1-phosphatase or dephosphorylated to inositol by inositol monophosphatase.

Cortistatin-14 is a neuropeptide have structural similarity to somatostatin-14. It is produced in the cortex and hippocampus of central nervous system.

2,4-Dihydroxyallylbenzene-2-O-β-D-glucopyranoside is a phenylpropanoid glycoside [1].

3-O-Feruloyl-6′-O-(4-O-β-D-glucopyranosylferuloyl)sucrose, a natural compound, is isolable from Lilium henryi Baker [1].

[D-Arg2]Dermorphin-(1-4) amide is an N-terminal truncated peptide of [D-Arg2]dermorphin noted for its hypothermic and analgesic effects. This compound also demonstrates degradation when subjected to soluble mouse liver and brain extracts [1].

4-(β-D-Glucopyranosyloxy)benzoic acid, a phenolic glucoside, can be isolated from fennel seeds [1].

Protoapigenin 4′-O-β-D-glucoside, a flavonoid glycoside, is isolatable from Thelypteris torresiana [1].

Narciclasine-4-O-β-D-glucopyranoside, a compound with anticancer activity [1], can be isolated from Pancratium maritimum.

Matairesinol 4′-O-β-D-glucopyranoside is a natural product isolated from Trachelospermum jasminoides.

3,3'-Di-O-methylellagic acid 4'-glucoside is a natural product

Resveratrol-4'-O-D-Glucuronide has anti-fat accumulation properties, is metabolized by resveratrol, and can be used in metabolism-related studies.

[D-Pro4,D-Trp7,9] Substance P (4-11) acts as a potent antagonist to Substance P, significantly reducing plasma aldosterone (ALDO) concentrations[1].

Leukotrienes (LTs) are a group of acute inflammatory mediators derived from arachidonic acid in leukocytes. The majority of these metabolites are formed through the 5-lipoxygenase (5-LO) pathway. 14,15-LTE4 is a metabolite of 14,15-LTC4 and 14,15-LTD4, an alternate class of LTs synthesized by a pathway involving the dual actions of 15- and 12-LOs on arachidonic acid via 15-HpETE and 14,15-LTA4 intermediates. These metabolites are classified as eoxins because they are formed mostly by eosinophils. Mast cells and nasal polyps can synthesize 14,15-LTC4 as well, however metabolism to 14,15-LTE4 in these cells and tissue has not been documented. 14,15-LTE4 increases vascular permeability of human endothelial cell monolayers with about 10-fold less potency than LTC4, but approximately 100-fold greater potency than histamine.

(D-Trp8,D-Cys14)-Somatostatin-14, a synthetic analogue of somatostatin, is utilized in the study of metabolic-related diseases [1] [2].

Kaempferol-4'-O-beta-D-glucopyranoside is an antihypertensive agent.

4-O-D-Glucopyranosyl-p-coumaric acid is a useful organic compound for research related to life sciences. The catalog number is T126288 and the CAS number is 117405-49-9.

[D-Trp8] Somatostatin-14 is a potent tetradecapeptide analog of native somatostatin, exhibiting increased efficacy [1].

Compound 1, (25R)-Ruscogenin-3-yl α-L-rhamnopyranosyl-(1→2)-[β-D-xylopyranosyl-(1→4)]-β-D-glucopyranoside, is a steroidal saponin that can be isolated from the roots of Ophiopogon japonicus [1].

4-Chloro-3-methoxy-5-methylphenyl 6-O-(6-deoxy-β-L-mannopyranosyl)-β-D-glucopyranoside (compound 3), a natural anticancer agent extracted from Lilium regale, exhibits potent inhibitory effects on the proliferation of A549 lung cancer cells and holds promise for applications in cancer research [1].

Oxyresveratrol 4-O-β-D-glucopyranoside (Compound 3) is a natural product extracted from the root bark of Morus atropurpurea, with potential applications in the research of diabetes, arthritis, rheumatism, cough, and headache [1].

(2′S)-4′-O-β-D-apiofuranosyl-(1→6)-O-β-D-glucopyranosylvisamminol, a chromone glycoside, can be isolated from the roots of Saposhnikovia divaricata and exhibits weak anti-cancer activity in human cancer cell lines [1].

11-trans Leukotriene D4 (11-trans LTD4) is a C-11 double bond isomer of LTD4. LTD4 undergoes slow temperature-dependent isomerization to 11-trans LTD4 during storage. 11-trans LTD4 retains about 10-25 % of the potency for contraction of guinea pig ileum, trachea and parenchyma compared to LTD4. It exhibits an ED50 ranging between 12-60 nM for contraction of guinea pig trachea.

4(15),5,10(14)-Germacratrien-1-ol is a natural product for research related to life sciences. The catalog number is TN2997 and the CAS number is 81968-62-9.

[Deamino-4-valine, 8-D-arginine]-Vasopressin (dVDAVP) is a highly potent and specific antidiuretic agent, exhibiting prolonged effects [1] [2].

4-Nitrophenyl α-D-galactopyranoside (PNP-alpha-D-Gal) (PNP-alpha-D-Gal) is an artificial substrate of 4-nitrophenyl (pNP) glycopyranoside for detecting α-galactosidase activity. The amount of released pNP is significantly increased when PNP-alpha-D-Gal is used as substrates.