2,5dimethyl celecoxib

2,2-Dimethyl-5-(2,5-xylyloxy)valeramide (5-(2,5-dimethylphenoxy)-2,2-dimethylpentanamide) is a compound of the phenoxy family. It has been shown to have stimulatory effects on the nervous system, including increased neuronal firing rates, increased synaptic transmission and increased neurotransmitter release. It has also been shown to have stimulatory effects on the cardiovascular system, including increased heart rate and blood pressure.

1,3-Dimethyl-2-oxobenzimidazole-5-carbaldehyde serves as an intermediate.

6-[(3S,8S,9S,10R,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxo-1H-pyridine-3,4-dicarbonitrile is a biologically active compound, which is utilized for research in the fields of chemistry and life sciences.

3-[7 ,7- dimethyl-5-oxo -6H-pyrrolo[3,4-b]pyridin-2-yI]-1H-indole-7 -carbonitrile is an androgen receptor modulator.

rel-5-(4-Chloro-2-fluorophenyl)-2,3-dimethyl-7-[(2R,4S)-tetrahydro-2-(1-methyl-1H-pyrazol-4-yl)-2H-pyran-4-yl]pyrido[3,4-b]pyrazine has an EC50 value of ≤ 0.05 μM and an E.max value of > 250 μM for TREM2.

N-(2-chloro-3-((3,5-dimethyl-4-oxo-3,4-dihydroquinazolin-6-yl)oxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethanesulfonamide is a useful organic compound for research in chemistry and life sciences.

(4R,4aS,5aS,6aR,6bS,7aR)-4-Hydroxy-3,6b-dimethyl-5-methylene-4,4a,5,5a,6,6a,7,7a-octahydrocyclopropa[2,3]indeno[5,6-b]furan-2(6bH)-one is a sesquiterpene lactone featuring a complex bicyclic structure [1].

2,5-Dimethyl-3(2H)-furanone (2,5-Dimethyl-2,3-dihydrofuran-3-one) is a non-genotoxic flavoring substance [1].

Compound 7a, (Z)-(1R,3R,4R,4aS,8R,8aR)-3,4,8,8a-tetramethyl-7-oxo-4-(2-(5-oxo-2,5-dihydrofuran-3-yl)ethyl)decahydronaphthalen-1-yl 2-methylbut-2-enoate, is a clerodane diterpene [1].

2,5-Dimethyl-4-methoxy-3(2H)-furanone is a natural product.

4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one (Fenugreck Lactone) is a kind of food spice mainly used in caramel, brown sugar, whisky, marshmallow, coffee, toffee and other flavors.

2,5-dimethyl Celecoxib is a derivative of celecoxib that does not inhibit COX-2 (IC50 = >100 μM).1 It does inhibit microsomal prostaglandin E synthase-1 (mPGES-1) in HeLa cells (IC50 = 15.6 μM) and reduces prostaglandin E2 production in HeLa, A549, and HCA-7 cells (IC50s = 0.64, 0.83, and 3.08 μM, respectively).2 It inhibits proliferation of drug-sensitive RPMI8226 and multidrug-resistant 8226/Dox40 multiple myeloma cells, as well as increases the rate of apoptosis when used at concentrations of 20 and 30 μM.3 2,5-dimethyl Celecoxib reduces the expression of survivin, cyclin A, cyclin B, MEK1, and MEK2 in 8226/Dox40 cells. The antiproliferative effect of 2,5-dimethyl celecoxib is independent of mPGES-1 inhibition.2References1. Zhu, J., Song, X., Lin, H.-P., et al. Using cyclooxygenase-2 inhibitors as molecular platforms to develop a new class of apoptosis-inducing agents. J. Natl. Cancer Inst. 94(23), 1745-1757 (2002).2. Wobst, I., Schiffmann, S., Birod, K., et al. Dimethylcelecoxib inhibits prostaglandin E2 production. Biochem. Pharmacol. 76(1), 62-69 (2008).3. Kardosh, A., Soriano, N., Liu, Y.-T., et al. Multitarget inhibition of drug-resistant multiple myeloma cell lines by dimethyl-celecoxib (DMC), a non-COX-2 inhibitory analog of celecoxib. Blood 106(13), 4330-4338 (2005). 2,5-dimethyl Celecoxib is a derivative of celecoxib that does not inhibit COX-2 (IC50 = >100 μM).1 It does inhibit microsomal prostaglandin E synthase-1 (mPGES-1) in HeLa cells (IC50 = 15.6 μM) and reduces prostaglandin E2 production in HeLa, A549, and HCA-7 cells (IC50s = 0.64, 0.83, and 3.08 μM, respectively).2 It inhibits proliferation of drug-sensitive RPMI8226 and multidrug-resistant 8226/Dox40 multiple myeloma cells, as well as increases the rate of apoptosis when used at concentrations of 20 and 30 μM.3 2,5-dimethyl Celecoxib reduces the expression of survivin, cyclin A, cyclin B, MEK1, and MEK2 in 8226/Dox40 cells. The antiproliferative effect of 2,5-dimethyl celecoxib is independent of mPGES-1 inhibition.2 References1. Zhu, J., Song, X., Lin, H.-P., et al. Using cyclooxygenase-2 inhibitors as molecular platforms to develop a new class of apoptosis-inducing agents. J. Natl. Cancer Inst. 94(23), 1745-1757 (2002).2. Wobst, I., Schiffmann, S., Birod, K., et al. Dimethylcelecoxib inhibits prostaglandin E2 production. Biochem. Pharmacol. 76(1), 62-69 (2008).3. Kardosh, A., Soriano, N., Liu, Y.-T., et al. Multitarget inhibition of drug-resistant multiple myeloma cell lines by dimethyl-celecoxib (DMC), a non-COX-2 inhibitory analog of celecoxib. Blood 106(13), 4330-4338 (2005).

3',5'-Di-O-acetyl-2'-deoxy-5,N3-dimethyl uridine is a Nucleoside Derivative - N-Alkylated nucleoside.

4,4-Dimethyl-2-cyclopenten-1-one, derived from Apocyniveneti Folium, exhibits enhanced tumor-specific cytotoxicity [1].

1,3-Dioxane, 5,5-dimethyl-2-phenyl- is a bioactive chemical.

N-(4-Chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethyl propanamide belongs to Heterocyclic Compounds - Purine; Intermediates and Building Blocks - Nucleoside base, Electrophile; Scaffold and Template.

N-(2-(Diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide is a useful organic compound for research related to life sciences. The catalog number is T66203 and the CAS number is 356068-86-5.

7-[(7-Methoxy-3,7-dimethyl-2,5-octadienyl)oxy]-2H- is a useful organic compound for research related to life sciences. The catalog number is T125949 and the CAS number is 1388140-07-5.

(R)-2,5-Ddioxopyrrolidin-1-yl 2-((tert-butoxycarbonyl)amino)-3-phenylpropanoate is a useful organic compound for research related to life sciences. The catalog number is T66773 and the CAS number is 3674-18-8.

N3,5-Dimethyl-2’-O-(2-methoxyethyl) uridine, a purine nucleoside analog, exhibits broad antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms include the inhibition of DNA synthesis and the induction of apoptosis, among others [1].

2-Amino-3',5'-di-O-acetyl-N6,N6-dimethyl-2'-O-methyl adenosine is a Nucleoside Derivative - 6-Modified purine nucleoside; 2'-Modified nucleoside.

2-(5-(3-(5-Carboxypentyl)-1,1-dimethyl-1,3-dihydro-2H-benzo[e]indol-2-ylidene)penta-1,3-dien-1-yl)-1,1,3-trimethyl-1H-benzo[e]indol-3-ium is a useful organic compound for research related to life sciences and the catalog number is T64625.

2,4-Dihydroxy-6-(5,7-dimethyl-2-oxo-3,5-nonadienyl is a useful organic compound for research related to life sciences and the catalog number is T130895.

2-Methoxy-1,6-dimethyl-5-vinyl-9,10-dihydrophenanthren-7-ol is a natural product for research related to life sciences. The catalog number is TN5697 and the CAS number is 2266586-31-4.

8-(7-Hydroxy-3,7-dimethyl-2,5-octadienyloxy)psoralen is a natural product for research related to life sciences. The catalog number is TN3267 and the CAS number is 144398-34-5.

Nucleoside Derivatives - 2-Modified purine nucleosides; 2’-Modified nucleosides; N-Alkylated nucleosides

tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-3,4-dihydro-2H-pyran-3-yl)carbamate is a useful organic compound for research related to life sciences. The catalog number is T66644 and the CAS number is 1172623-98-1.

1,7'-Dimethyl-2'-propyl-1H,1'H-2,5'-bibenzo[d]imidazole is a useful organic compound for research related to life sciences. The catalog number is T65771 and the CAS number is 152628-02-9.

2',3',5'-Tri-O-acetyl-5,N3-dimethyl uridine is a Nucleoside Derivative - N-Alkylated nucleoside.

2-(3-hexyl-2,5-dihydro-4-methyl-2,5-dioxo-1H-pyrro is a useful organic compound for research related to life sciences. The catalog number is T125222 and the CAS number is 2431889-83-5.

(4aR,4bS,6aS,7S,9aS,9bS,11aR)-4a,6a-Dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid is a useful organic compound for research related to life sciences. The catalog number is T66996 and the CAS number is 104239-97-6.

3,5-Dimethyl-4-methoxy-2-pyridinemethanol is a useful organic compound for research related to life sciences. The catalog number is T67354 and the CAS number is 86604-78-6.

(S)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine is a useful organic compound for research related to life sciences. The catalog number is T65715 and the CAS number is 132335-44-5.

2-Amino-3’,5’-di-O-acetyl-N6,N6-dimethyl-2’-O-methyladenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine , Clofarabine , Fludarabine phosphate and Vidarabine [1] .

5,6-dimethyl-2-Thiouracil is a heterocyclic building block that has been used in the synthesis of anti-HIV-1 pyrimidinones.1 It has also been used as an internal standard for the quantification of thyreostats, including 2-thiouracil, in bovine plasma.2 |1. Navrotskii, M.B. Synthesis and anti-HIV-1 activity of new 2-[(2-phthalimidoethyl)thio]-4(3H)-pyrimidinone derivatives. Pharm. Chem. J. 39(9), 466-467 (2005).|2. Schmidt, K.S. In-house validation and factorial effect analysis of a liquid chromatography-tandem mass spectrometry method for the determination of thyreostats in bovine blood plasma. Anal. Bioanal. Chem. 406(3), 735-743 (2014).

1-Hydroxybisabola-2,10-dien-4-one is a natural product for research related to life sciences. The catalog number is TN5398 and the CAS number is 124898-71-1.

(4aR,4bS,6aS,7S,9aS,9bS,11aR)-4a,6a-Dimethyl-2-oxohexadecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid is a useful organic compound for research related to life sciences. The catalog number is T67601 and the CAS number is 103335-55-3.

Ethyl (4-(2-(3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamido)ethyl)phenyl)sulfonylcarbamate is a useful organic compound for research related to life sciences. The catalog number is T65924 and the CAS number is 318515-70-7.

Methyl 4-(((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)-2-methoxybenzoate is a useful organic compound for research related to life sciences. The catalog number is T67213 and the CAS number is 205448-64-2.

tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate is a useful organic compound for research related to life sciences. The catalog number is T66457 and the CAS number is 951127-25-6.

6-Amino-2,5-dihydro-2-(b-D-ribofuranosyl)-4H-pyrazolo[3,4-d]pyrimidin-4-one is a Nucleoside Derivative - 7-deaza-8-aza purine nucleoside.

N3,5-Dimethyl-2'-O-(2-methoxyethyl) uridine is a Nucleoside Derivative - 2'-Modified nucleoside, N-Methylated/ alkylated nucleoside.

Nucleoside Derivatives - 6-Modified purine nucleosides, 2’-Modified nucleosides；N-Methylated nucleosides；Naturally modified ribo-nucleosides

8-(1,1-Dimethyl-2-propenyl)-3'-methoxykaempferol is a natural product for research related to life sciences. The catalog number is TN5521 and the CAS number is 1859979-00-2.

2-Chloro-N6,N6-dimethyl-2'-deoxyadenosine is a Nucleoside Derivative - Halo-nucleoside, 2-Modified purine nucleoside, 6-Modified purine nucleoside.

Cyclo[N1'-(1,1-dimethyl-2-propenyl)tryptophyltrypt is a useful organic compound for research related to life sciences. The catalog number is T125220 and the CAS number is 244066-05-5.

(3S,8S,9S,10R,13R,14S,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl (Z)-octadec-9-en-1-yl carbonate is a useful organic compound for research related to life sciences. The catalog number is T65075 and the CAS number is 17110-51-9.

Ethyl (S)-2-[(S)-4-Methyl-2,5-dioxo-3-oxazolidinyl]-4-phenylbutanoate is a useful organic compound for research related to life sciences. The catalog number is T67596 and the CAS number is 84793-24-8.

Dimethyl (2-oxo-4-phenylbutyl)phosphonate is a useful organic compound for research related to life sciences. The catalog number is T65121 and the CAS number is 41162-19-0.

tert-Butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate is a useful organic compound for research related to life sciences. The catalog number is T66277 and the CAS number is 289042-12-2.