hs-c-6-peg9-acid

HS-C6-PEG9-acid is a PEG-based linker (PROTACs) that joins two essential ligands, facilitating selective protein degradation via the ubiquitin-proteasome system within cells.

6-Maleimidocapronic acid, an alkyl chain-based PROTAC linker, is utilized in the synthesis of PROTACs (proteolysis-targeting chimeras).

6-Bromohexylphosphonic acid, an alkyl chain-based linker, is commonly used in the synthesis of PROTACs (proteolysis targeting chimeras) [1].

Boc-6-aminohexanoic acid, an alkyl ether-based linker, is utilized in PROTAC synthesis.

Fmoc-9-aminononanoic acid is an alkane chian with terminal Fmoc-protected amine and carboxylic acid groups. The compound can be used as a PROTAC linker in the synthesis of PROTACs and and other conjugation applications. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

6-Maleimidocaproic acid-PFP ester is a hydrocarbon-based PROTAC linker suitable for synthesizing PROTACs [1].

9-(Boc-amino)nonanoic Acid is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. The compound can be used as a PROTAC linker in the synthesis of PROTACs. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.

6-Maleimidocaproic acid sulfo-NHS serves as an alkyl/ether-based PROTAC linker, facilitating the synthesis of PROTACs.

m-PEG4-(CH2)6-Phosphonic acid is a polyethylene glycol-based linker compound designed for synthesizing proteolysis targeting chimeras (PROTACs)[1].

m-PEG6-(CH2)6-Phosphonic acid functions as a PEG-based PROTAC linker for PROTAC synthesis [1].