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hydroxy desmethyl bosentan

" in TargetMol Product Catalog
  • Inhibitor Products
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    TargetMol | Activity
Hydroxy desmethyl Bosentan
T11584253688-62-9
Hydroxy desmethyl Bosentan (Ro 64-105) is a Bosentan metabolism produced by the cytochrome P450 enzymes CYP2C9 and CYP3A4 in the liver.
  • $294
35 days
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Desmethyl Bosentan
T37351253688-61-8
Desmethyl bosentan is an active metabolite of the endothelin receptor antagonist bosentan .1Desmethyl bosentan (25 μM) activates the pregnane X receptor (PXR) in CV-1 monkey kidney cells expressing the human receptor in a reporter assay. 1.van Giersbergen, P.L.M., Gnerre, C., Treiber, A., et al.Bosentan, a dual endothelin receptor antagonist, activates the pregnane X nuclear receptorBr. J. Clin. Pharmacol.54(5)561-562(2002)
  • $296
35 days
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Hydroxy bosentan
T19360253688-60-7
Hydroxy bosentan (Ro 48-5033) is a primary metabolite of Bosentan (BOS) metabolized by the cytochrome P450 system in the liver. Hydroxy bosentan assists BOS pharmacologically, retaining 10%-20% activities.
  • $288
35 days
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