jms-17-2

JMS-17-2 is a potent and selective antagonist of CX3CR1 (IC50: 0.32 nM).

JMS-17-2 hydrochloride, a highly potent and selective CX3CR1 antagonist with an IC 50 value of 0.32 nM, effectively impedes the metastatic seeding and colonization process of breast cancer cells.

2-chloro-5-(16,18-dioxo-17-azapentacyclo[6.6.5.0~2,7~.0~9,14~.0~15,19~]nonadeca-2,4,6,9,11,13-hexaen-17-yl)benzoic acid can be used to synthesize a variety of organic compounds.

6-[(3S,8S,9S,10R,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxo-1H-pyridine-3,4-dicarbonitrile is a biologically active compound, which is utilized for research in the fields of chemistry and life sciences.

Compound 3h, also known as SARS-CoV-2 3CLpro-IN-17, is a selective inhibitor of the SARS-CoV-2 3CL protease, demonstrating an IC50 of 0.322 μM [1].

SARS-CoV-2-IN-17 (Compound 16) is a highly effective inhibitor of the SARS-CoV-2 nucleocapsid protein (NPro), demonstrating potent antiviral activity with an EC50 value of 2.18 μM and binding to NPro with a low Kd value of 7.82 μM, underscoring its potency as a NPro ligand [1].

Dynorphin (2-17) (porcine), a Prodynorphin-derived peptide, can alleviate somatic symptoms of Morphine dependence during withdrawal [1].

Dynorphins are a class of opioid peptides that arise from the precursor protein prodynorphin. When prodynorphin is cleaved during processing by proprotein convertase 2 (PC2), multiple active peptides are released: dynorphin A, dynorphin B, and α/β-neo-end

VEGFR-2-IN-17 (Compound 15a) is a highly potent inhibitor of Vascular Endothelial Growth Factor Receptor 2 (VEGFR-2) with an IC50 of 67.25 nM and exhibits significant antitumor properties [1].

[3-(tetrahydro-2H-pyran-2-yloxy)androstan-17-yl]methanol is a useful organic compound for research related to life sciences and the catalog number is T131410.

(3S,8S,9S,10R,13R,14S,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl (Z)-octadec-9-en-1-yl carbonate is a useful organic compound for research related to life sciences. The catalog number is T65075 and the CAS number is 17110-51-9.

(2b,3a,5a,16b,17b)-17-Acetoxy-3-hydroxy-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane is a useful organic compound for research related to life sciences. The catalog number is T66654 and the CAS number is 119302-24-8.

17-(iodomethyl)-3-(tetrahydro-2H-pyran-2-yloxy)androstane is a useful organic compound for research related to life sciences and the catalog number is T131409.

COX-2-IN-17 is a potent, blood-brain barrier permeable COX-2 (cyclooxygenase-2) inhibitor (IC50: 0.02 μM) with anti-inflammatory and analgesic activity.

Dynorphin (2-17), amide (porcine) is a dynorphin derivative from the opioid peptide class, synthesized from the precursor protein dynorphinogen, and exhibits analgesic properties, playing a pivotal role in regulating pain, addiction, and mood [1].