pomalidomide 4' peg2 azide 

Pomalidomide 4'-PEG2-azide is a synthetic E3 ligase ligand-linker conjugate, comprising a Pomalidomide-based cereblon ligand and a linker.

Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- (4-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]butanoic acid) is a Cereblon ligand with alkyl linker and terminal acid for onward chemistry.

Pomalidomide-PEG2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based CRBN ligand and linker used in PROTAC technology.

Pomalidomide-PEG2-OH enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology.

Azide-PEG-azide (MW 20000) is a polyethylene glycol (PEG)-based linker compound used in the synthesis of Proteolysis Targeting Chimeras (PROTACs)[1].

Azide-PEG-amine (MW 3500) is a polyethylene glycol (PEG) linker compound, designed for the synthesis of proteolysis targeting chimeric molecules (PROTACs)[1].

Pomalidomide 4'-alkylC6-azide, a Pomalidomide-based cereblon (CRBN) ligand, facilitates the recruitment of CRBN protein. It is designed to attach to a protein through a linker, enabling the formation of PROTAC [1].

Pomalidomide-PEG2-Tos is a compound that consists of an E3 ligase ligand-linker conjugate. It is composed of a cereblon ligand conjugated to a two-unit PEG linker[1].

(S,R,S)-AHPC-(C3-PEG)2-C6-Cl is a small molecule HaloPROTAC incorporating the (S,R,S)-AHPC-based VHL ligand and a 2-unit PEG linker, capable of inducing degradation of GFP-HaloTag7 in cell-based assays [1].

2-(Azido-PEG2-amido)-13-propandiol is a Polyethylene glycol (PEG)-based PROTAC linker used for synthesizing PROTACs[1].

Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH is a chemically synthesized E3 ligase ligand-linker conjugate, incorporating the cereblon ligand from Pomalidomide and a linker used in PROTAC technology. It facilitates targeted protein degradation by modulating E3 ligase activity, thereby enabling the selective elimination of specific proteins of interest.

N-(Boc-PEG2)-N-bis(PEG3-azide) is a polyethylene glycol (PEG)-derived linker utilized in the synthesis of proteolysis targeting chimeras (PROTACs)[1].

t-Boc-Aminooxy-PEG2-azide is a polyethylene glycol (PEG) derived linker compound used for the synthesis of proteolysis targeting chimeras (PROTACs)[1].

Azide-PEG2-Ms is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Thalidomide 4'-ether-PEG1-azide, a Thalidomide-based cereblon ligand, facilitates the recruitment of CRBN protein. This compound is capable of being linked to a protein ligand via a linker to construct PROTACs [1].

m-PEG-azide (MW 10000), a PEG-based linker for PROTACs, joins two essential ligands crucial for forming PROTAC molecules, enabling selective protein degradation through the ubiquitin-proteasome system within cells.

Biotin-PEG2-C6-azide is a PEG-based PROTAC linker used in the synthesis of PROTAC.

m-PEG2-4-nitrophenyl carbonate, a PEG-derived linker, is utilized in PROTACs synthesis [1].

N-(Acid-PEG2)-N-bis(PEG3-azide) is a polyethylene glycol (PEG)-based linker used in synthesizing proteolysis targeting chimeras (PROTACs), a unique class of molecules designed for targeted protein degradation[1].

m-PEG-azide (MW 5000) is a PEG-based linker for PROTACs, facilitating the conjugation of two essential ligands to enable selective protein degradation via the ubiquitin-proteasome system in cells.

m-PEG-azide (MW 2000) is a PEG-based linker used in PROTACs to join two essential ligands, facilitating the selective degradation of target proteins through the ubiquitin-proteasome system within cells.

Hydroxy-PEG2-(CH2)2-Boc is an uncleavable ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs).

m-PEG2-azide, a PEG-based PROTAC linker, is utilized in the synthesis of PROTACs.

Pomalidomide-PEG3-azide is a chemically synthesized conjugate comprised of a cereblon ligand based on Pomalidomide, an E3 ligase ligand-linker, and a 3-unit PEG linker. This conjugate is specifically designed for use in PROTAC technology.

Functionalized cereblon ligand for PROTAC research and development; incorporates an E3 ligase ligand plus a PEG2 linker with terminal amine ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

DSPE-PEG-2-Aminoethyl-alpha-mannopyranoside (MW 2000) is a polyethylene glycol (PEG) derived linker used in the synthesis of proteolysis targeting chimeras (PROTACs) [1].

Azido-PEG2-azide, a PEG-based PROTAC linker, is utilized in PROTAC synthesis.

Pyrene-PEG2-azide is a PEG-based linker for PROTACs, connecting two essential ligands necessary for PROTAC molecule formation and facilitating selective protein degradation via the ubiquitin-proteasome system within cells.

Lenalidomide 4'-PEG2-azide, a Lenalidomide-derived Cereblon ligand, facilitates the recruitment of CRBN protein. This compound can be tethered via a linker to a protein ligand, enabling the formation of PROTAC [1].

Lenalidomide 4'-alkyl-C3-azide (compound 4a), a chemically modified version of the orally active immunomodulator lenalidomide, is engineered for the synthesis of PROTACs. This compound, serving as a ligand for the ubiquitin E3 ligase cereblon (CRBN), integrates an Azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-bearing molecules. Additionally, it can undergo strain-promoted alkyne-azide cycloaddition reactions (SPAAC) with molecules containing DBCO or BCN groups [1].

DBCO-(PEG2-VC-PAB-MMAE)2 consists of Monomethyl auristatin E (MMAE), a potent tubulin inhibitor and toxin payload in antibody-drug conjugate [1], conjugated to the cleavable linker DBCO-(PEG2-VC-PAB)2, serving as the cytotoxic component in this formulation.

Aminooxy-PEG2-azide, a PEG-based PROTAC linker, is utilized for the synthesis of PROTACs[1] and serves as a non-cleavable 2-unit PEG ADC linker in the synthesis of antibody-drug conjugates (ADCs)[2].

Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 is a synthetic conjugate that combines a Thalidomide-based cereblon ligand and a linker, commonly utilized in PROTAC technology. This compound serves as a connector between the target protein and the E3 ligase, facilitating targeted protein degradation.

Functionalized cereblon ligand for PROTAC research and development; incorporates an E3 ligase ligand plus an alkylC8 linker with terminal acid ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

UV Cleavable Biotin-PEG2-Azide, a PEG-based PROTAC linker, enables the synthesis of PROTACs[1].

Benzyl-PEG2-azide, a PEG-based PROTAC linker, is utilized in the synthesis of PROTACs.

Boc-N-Amido-PEG2-C2-azide is a polyethylene glycol (PEG)-based linker used in the synthesis of proteolysis-targeting chimeras (PROTACs) [1].

Fluorescein-thiourea-PEG2-azide is a PEG-derived linker commonly used in the synthesis of PROTACs[1].

Pomalidomide-PEG1-azide is an E3 ligase ligand-linker conjugate that combines the cereblon ligand based on Pomalidomide with a linker. This compound is instrumental in designing PROTAC BRD4 Degrader-1[1].

Bromo-PEG2-C2-azide is a non-cleavable ADC linker employed in the synthesis of antibody-drug conjugates (ADCs)[1].

(2-Pyridyldithio)-PEG2-Boc is a polyethylene glycol-based PROTAC linker used in the synthesis of PROTACs [1].

Pomalidomide 4'-PEG5-amine, a cereblon ligand designed for PROTAC research and development, features an integrated E3 ligase ligand and a PEG5 linker ending in an amine for easy conjugation to target protein ligands. It is among a series of functionalized tool molecules specifically crafted for PROTAC R&D.

Pomalidomide 4'-PEG5-azide, a cereblon (CRBN) ligand based on Pomalidomide, facilitates the recruitment of CRBN protein. It can be conjugated through a linker to another ligand, forming a proteolysis-targeting chimera (PROTAC) [1].

1,1,1-Trifluoroethyl-PEG2-azide is a polyethylene glycol-based azide linker compound used in synthesizing proteolysis-targeting chimeras (PROTACs)[1].

Azide-PEG-azide (MW 2000) is a polyethylene glycol (PEG)-based linker used for synthesizing proteolysis-targeting chimeras (PROTACs)[1].

Azide-PEG-alcohol, a polyethylene glycol (PEG)-based PROTAC linker with a molecular weight of 2000, functions as a versatile option for the synthesis of PROTACs[1].

Azide-PEG-amine (MW 2000) is a Polyethylene Glycol (PEG)-derived linker compound used in the synthesis of Proteolysis Targeting Chimeras (PROTACs)[1].

4-Methyl-4-(pyridin-2-yldisulfanyl)pentanoic acid is a cleavable linker compound used in the synthesis of antibody-drug conjugates (ADCs) [1].