T60675 |
AMPK activator 2
|
2410961-69-0
|
98%
|
|
AMPK activator 2 is a chloroformin derivative with potential anticancer activity, which can up-regulate AMPK signaling pathway and down-regulate mTOR/4EBP1/p70S6...
|
T20232 |
Kazinol B
|
99624-27-8
|
98%
|
|
Kazinol B is an inhibitor of nitric oxide (NO) production, an isopentenylated flavan with a dimethylpyran ring.Kazinol B improves insulin sensitivity by activati...
|
TN3042 |
4-Hydroxycinnamamide
|
194940-15-3
|
98%
|
|
4-Hydroxycinnamamide has antioxidant activity. 4-Hydroxycinnamamide derivatives are specific inhibitors of tyrosine-specific protein kinases.
|
T79232 |
MARK4 inhibitor 2
|
|
98%
|
|
MARK4 Inhibitor 2 is a potent inhibitor of Microtubule Affinity-Regulating Kinase 4 (MARK4), exhibiting a Kₘ of 6.3×10⁷ and an IC₅₀ of 0.82 μM. It effectively in...
|
T82165 |
HTH-02-006
|
|
98%
|
|
HTH-02-006, a NUAK2 inhibitor (IC50 = 126 nM), decreases phosphorylated MYPT1 levels in HuCCT-1 cells and inhibits YAP-driven cell proliferation, hepatomegaly, a...
|
T83125 |
AMPK-α1β1γ1 activator 1
|
1943510-86-8
|
98%
|
|
AMPK-α1β1γ1 activator 1 (M1), an acyl glucuronide metabolite derived from an Indole-3-carboxylic Acid-based AMPK activator, selectively activates the β1 isoforms...
|
T83127 |
AMPK activator 13
|
|
98%
|
|
AMPK Activator 13 is a potent activator of the AMPK pathway, effectively inhibiting mitotic clonal expansion in 3T3-L1 cells and enhancing mitochondrial oxygen c...
|
TN5013 |
Shizukaol D
|
142279-42-3
|
98%
|
|
Shizukaol D exerts a growth inhibition effect on liver cancer cells in a dose- and time-dependent manner by modulating wnt signalling pathway. Shizukaol D may be...
|
T10105 |
3α-Hydroxymogrol
|
1343402-73-2
|
98%
|
|
3α-Hydroxymogrol is a triterpenoid isolated from Siraitia grosvenorii Swingle. It is a potent AMPK activator and enhances AMPK phosphorylation.
|
T11570 |
HL271
|
1422365-52-3
|
98%
|
|
HL271, a derivative of metformin, is a potent AMPK activator that increases AMPK phosphorylation. HL271 attenuates aging-associated cognitive impairment.
|
T22460 |
XMD-17-51
|
1628614-50-5
|
98%
|
|
XMD-17-51 is a potent and highly selective NUAK1 inhibitor.
|
TN4382 |
Kazinol A
|
99624-28-9
|
98%
|
|
Kazinol A shows strong inhibition of arachidonic acid (AA)-induced platelet aggregation. It also exhibits potent inhibition with IC50 values ranging 0.6-164 M ag...
|
T10312 |
Ampkinone
|
1233082-79-5
|
98%
|
|
Ampkinone is an indirect AMPK activator.
|
TL0014 |
Pinusolide
|
31685-80-0
|
98%
|
|
Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, a...
|
TN1868 |
Ligupurpuroside A
|
147396-01-8
|
98%
|
|
Ligupurpuroside A has antioxidant,and hypolipidemic effects, it can significantly inhibit lipid accumulation in HepG2 cell at the concentration of 50 μMol/L.
|
T1456 |
Doxorubicin
|
23214-92-8
|
98%
|
|
Doxorubicin (Adriamycin) is a Topoisomerase II (Top2) inhibitor with antineoplastic activity.
|
T16113 |
ML753286
|
1699720-89-2
|
98%
|
|
ML753286 has high permeability and low to medium clearance in rodent and human liver S9 fractions. ML753286 is an orally active and selective inhibitor of BCRP (...
|
TN1870 |
Ligupurpuroside C
|
1194056-33-1
|
98%
|
|
Ligupurpuroside C can significantly inhibit lipid accumulation in HepG2 cell at the concentration of 50 μMol/L.
|
T16166 |
N-[(4-Aminophenyl)methyl]adenosine
|
95523-13-0
|
98%
|
|
N-[(4-Aminophenyl)methyl]adenosine is an adenosine receptor inhibitor (Ki: 29 nM for Rat ecto-5′-Nucleotidase).
|
TN1670 |
Ganodermanondiol
|
107900-76-5
|
98%
|
|
Ganodermanondiol exhibits potent cytoprotective effects on t-BHP-induced hepatotoxicity in human liver-derived HepG2 cells, presumably through Nrf2-mediated anti...
|