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AMPK

AMPK (AMP-activated protein kinase) is an enzyme that plays a role in cellular energy homeostasis. It consists of three proteins (subunits) that together make a functional enzyme. The net effect of AMPK activation is stimulation of hepatic fatty acid oxidation andketogenesis, inhibition of cholesterol synthesis, lipogenesis, and triglyceride synthesis, inhibition of adipocyte lipolysis and lipogenesis, stimulation of skeletal muscle fatty acid oxidation and muscle glucose uptake by pancreatic beta-cells. AMPK acts as a metabolic master switch regulating several intracellular systems including the cellular uptake of glucose, the β-oxidation of fatty acids and the biogenesis of glucose transporter 4 (GLUT4) and mitochondria.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T3S0195 Nootkatone 4674-50-4 99.04%
Nootkatone
1. Nootkatone can provide effective tick control. 2. (+)-Nootkatone has antiallergic, anti-inflammatory, and antiplatelet activities. 3. Nootkatone can prevent o...
T0800 Danthron 117-10-2 99.03%
Danthron
Danthron (Antrapurol) is a natural product, regulates glucose, and lipid metabolism by activating AMPK.
T3546 STO-609 52029-86-4 98.95%
STO-609
STO-609 is a specific and cell-permeable inhibitor of the Ca2+/calmodulin-dependent protein kinase kinase (CaM-KK) for recombinant CaM-KKα/KKβ (Ki: 80/15 ng/mL)....
T5S2361 Epiberberine 6873-09-2 98.95%
Epiberberine
1. Epiberberine may be caused drug interactions based on CYP2D6 enzyme. 2. Epiberberine has anti-adipogenic effect is mediated by downregulation of the Raf/MEK1/...
TN1990 Norathyriol 3542-72-1 98.93%
Norathyriol
Norathyriol is a potent PTP1B inhibitor with good cell permeability and oral availability.
T6146 Dorsomorphin dihydrochloride 1219168-18-9 98.89%
Dorsomorphin dihydrochloride
Dorsomorphin dihydrochloride (BML-275 2HCl) is a potent, selective and ATP-competitive AMPK inhibitor (Ki: 109 nM) and does not exhibit significant activity on s...
TN2179 Saponarin 20310-89-8 98.84%
Saponarin
Saponarin (Petrocomoside) shows in vitro and in vivo hepatoprotective and antioxidant activity against CCl4-induced liver damage.
T6285 GSK-690693 937174-76-0 98.78%
GSK-690693
GSK-690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. Phase 1.
T2854 Phillyrin 487-41-2 98.76%
Phillyrin
Phillyrin (Forsythin) is a novel AMPK activator, has anti-obesity effects in nutritive obesity mice, it can prevent lipid accumulation in HepG2 cells by blocking...
T5497 AMAROGENTIN 21018-84-8 98.75%
AMAROGENTIN
Amarogentin is mainly extracted from Swertia and Gentiana roots. It plays cemopreventive/therapeutic role during liver carcinogenesis through modulation of cell ...
T19661 8-Chloroadenosine 34408-14-5 98.75%
8-Chloroadenosine
8-Chloroadenosine (NSC-354258) is a 5' AMP-activated protein kinase agonist potentially for the treatment of chronic lymphocytic leukemia. 8-chloroadenosine acti...
T7955 EB-3D 1839150-63-8 98.75%
EB-3D
EB-3D is a potent and selective choline kinase alpha 1 (ChoKα1) inhibitor(IC50 : 1 μM).with anti-cancer activity.
T2468 A-769662 844499-71-4 98.72%
A-769662
A-769662 is an effective, reversible AMPK activator(EC50=0.8 μM).
T8476 RSVA405 140405-36-3 98.71%
RSVA405
RSVA405 is an AMPK activator (EC50 = 1 μM), and is STAT3 inhibitor
T9219 WH-4-025 1876463-35-2 98.7%
WH-4-025
WH-4-025 is a Salt-inducible kinase (SIK) inhibitor.
T5187 MK-3903 1219737-12-8 98.63%
MK-3903
MK-3903 is a potent and selective AMPK activator (EC50: 8 nM).
T11947 MARK4 inhibitor 1 2271081-58-2 98.59%
MARK4 inhibitor 1
MARK4 inhibitor 1 inhibits cancer cell proliferation, metastasis and induces apoptosis. MARK4 inhibitor 1 is a potent microtubule affinity-regulating kinase 4 (M...
T4S0800 Demethyleneberberine 25459-91-0 98.54%
Demethyleneberberine
Demethyleneberberine, which is composed of a potential antioxidant structure, could penetrate the membrane of mitochondria and accumulate in mitochondria either ...
T5162 MRT67307 HCl (1190378-57-4(free base)) T5162 98.52%
MRT67307 HCl (1190378-57-4(free base))
MRT67307 is a kinase inhibitor of TBK1, MARK1-4, IKKε, and NUAK1 (IC50: 19, 27-52, 160, and 230 nM, respectively).
T6129 GSK-1070916 942918-07-2 98.51%
GSK-1070916
GSK-1070916 (GSK-1070916A) is a reversible and ATP-competitive inhibitor of Aurora B/C with IC50 of 3.5 nM/6.5 nM. It displays >100-fold selectivity against the ...
Nootkatone
T3S0195
1. Nootkatone can provide effective tick control. 2. (+)-Nootkatone has antiallergic, anti-inflammatory, and antiplatelet activities. 3. Nootkatone can prevent o...
Danthron
T0800
Danthron (Antrapurol) is a natural product, regulates glucose, and lipid metabolism by activating AMPK.
STO-609
T3546
STO-609 is a specific and cell-permeable inhibitor of the Ca2+/calmodulin-dependent protein kinase kinase (CaM-KK) for recombinant CaM-KKα/KKβ (Ki: 80/15 ng/mL)....
Epiberberine
T5S2361
1. Epiberberine may be caused drug interactions based on CYP2D6 enzyme. 2. Epiberberine has anti-adipogenic effect is mediated by downregulation of the Raf/MEK1/...
Norathyriol
TN1990
Norathyriol is a potent PTP1B inhibitor with good cell permeability and oral availability.
Dorsomorphin dihydrochloride
T6146
Dorsomorphin dihydrochloride (BML-275 2HCl) is a potent, selective and ATP-competitive AMPK inhibitor (Ki: 109 nM) and does not exhibit significant activity on s...
Saponarin
TN2179
Saponarin (Petrocomoside) shows in vitro and in vivo hepatoprotective and antioxidant activity against CCl4-induced liver damage.
GSK-690693
T6285
GSK-690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. Phase 1.
Phillyrin
T2854
Phillyrin (Forsythin) is a novel AMPK activator, has anti-obesity effects in nutritive obesity mice, it can prevent lipid accumulation in HepG2 cells by blocking...
AMAROGENTIN
T5497
Amarogentin is mainly extracted from Swertia and Gentiana roots. It plays cemopreventive/therapeutic role during liver carcinogenesis through modulation of cell ...
8-Chloroadenosine
T19661
8-Chloroadenosine (NSC-354258) is a 5' AMP-activated protein kinase agonist potentially for the treatment of chronic lymphocytic leukemia. 8-chloroadenosine acti...
EB-3D
T7955
EB-3D is a potent and selective choline kinase alpha 1 (ChoKα1) inhibitor(IC50 : 1 μM).with anti-cancer activity.
A-769662
T2468
A-769662 is an effective, reversible AMPK activator(EC50=0.8 μM).
RSVA405
T8476
RSVA405 is an AMPK activator (EC50 = 1 μM), and is STAT3 inhibitor
WH-4-025
T9219
WH-4-025 is a Salt-inducible kinase (SIK) inhibitor.
MK-3903
T5187
MK-3903 is a potent and selective AMPK activator (EC50: 8 nM).
MARK4 inhibitor 1
T11947
MARK4 inhibitor 1 inhibits cancer cell proliferation, metastasis and induces apoptosis. MARK4 inhibitor 1 is a potent microtubule affinity-regulating kinase 4 (M...
Demethyleneberberine
T4S0800
Demethyleneberberine, which is composed of a potential antioxidant structure, could penetrate the membrane of mitochondria and accumulate in mitochondria either ...
MRT67307 HCl (1190378-57-4(free base))
T5162
MRT67307 is a kinase inhibitor of TBK1, MARK1-4, IKKε, and NUAK1 (IC50: 19, 27-52, 160, and 230 nM, respectively).
GSK-1070916
T6129
GSK-1070916 (GSK-1070916A) is a reversible and ATP-competitive inhibitor of Aurora B/C with IC50 of 3.5 nM/6.5 nM. It displays >100-fold selectivity against the ...
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TargetMol