AMPK

AMPK (AMP-activated protein kinase) is an enzyme that plays a role in cellular energy homeostasis. It consists of three proteins (subunits) that together make a functional enzyme. The net effect of AMPK activation is stimulation of hepatic fatty acid oxidation andketogenesis, inhibition of cholesterol synthesis, lipogenesis, and triglyceride synthesis, inhibition of adipocyte lipolysis and lipogenesis, stimulation of skeletal muscle fatty acid oxidation and muscle glucose uptake by pancreatic beta-cells. AMPK acts as a metabolic master switch regulating several intracellular systems including the cellular uptake of glucose, the β-oxidation of fatty acids and the biogenesis of glucose transporter 4 (GLUT4) and mitochondria.

Cat. No.	Product name	CAS No.	Purity
T9219	WH-4-025	1876463-35-2	98.7%
T9219	WH-4-025 is a Salt-inducible kinase (SIK) inhibitor.
T5187	MK-3903	1219737-12-8	98.63%
T5187	MK-3903 is a potent and selective AMPK activator (EC50: 8 nM).
T11947	MARK4 inhibitor 1	2271081-58-2	98.59%
T11947	MARK4 inhibitor 1 inhibits cancer cell proliferation, metastasis and induces apoptosis. MARK4 inhibitor 1 is a potent microtubule affinity-regulating kinase 4 (M...
T4S0800	Demethyleneberberine	25459-91-0	98.54%
T4S0800	Demethyleneberberine, which is composed of a potential antioxidant structure, could penetrate the membrane of mitochondria and accumulate in mitochondria either ...
T5162	MRT67307 HCl (1190378-57-4(free base))	T5162	98.52%
T5162	MRT67307 is a kinase inhibitor of TBK1, MARK1-4, IKKε, and NUAK1 (IC50: 19, 27-52, 160, and 230 nM, respectively).
T6129	GSK-1070916	942918-07-2	98.51%
T6129	GSK-1070916 (GSK-1070916A) is a reversible and ATP-competitive inhibitor of Aurora B/C with IC50 of 3.5 nM/6.5 nM. It displays >100-fold selectivity against the ...
T3863	Chikusetsusaponin IVa	51415-02-2	98.46%
T3863	Chikusetsusaponin IVa (Calenduloside F) is a novel AMPK activator, can induce insulin secretion from βTC3 cells via GPR4 mediated calcium and PKC pathways, may b...
T0853L	Adenosine 5'-monophosphate monohydrate	18422-05-4	98.36%
T0853L	Adenosine 5'-monophosphate monohydrate (5'-AMP) , also known as 5'-adenylic acid, is a nucleotide that is used as a monomer in RNA. It is an ester of phosphoric ...
T6S1784	Brazilin	474-07-7	98.31%
T6S1784	1. Brazilin (Braziletto) exhibits anti-hepatotoxic, antiplatelet effects. 2. Brazilin has cancer preventive effect, may inhibit T24 cell growth and trigger cell ...
T1477	AICAR	2627-69-2	98.21%
T1477	AICAR (NSC105823) is an AMP-activated protein kinase activator which is used for the treatment of acute lymphoblastic leukemia and may have applications in treat...
T4427	PF-06409577	1467057-23-3	98.16%
T4427	PF-06409577 is an effective, orally active, and specific allosteric activator of AMPK (EC50: 7 nM, for α1β1γ1).
T15137	DK419	2102672-22-8	98.15%
T15137	DK419 is an orally active inhibitor of Wnt/β-catenin signaling, with an IC50 of 0.19 μM. DK419 decreases protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 an...
T13368	YLF-466D	1273323-67-3	98.04%
T13368	YLF-466D (C24) is a newly developed AMPK activator, which inhibits platelet aggregation.
T2133	Adenosine monophosphate	61-19-8	98.04%
T2133	Adenosine monophosphate (AMP) is a purine ribonucleoside 5'-monophosphates and a key cellular metabolite in signal transduction and regulation of energy homeosta...
T16156	MT 63-78	1179347-65-9	98.03%
T16156	MT 63-78 is a specific and effective direct AMPK activator (EC50: 25 μM). MT 63-78 blocks prostate cancer growth by inhibiting the lipogenesis and mTORC1 pathway...
T74643	RSS0680	2769753-48-0	98.02%
T74643	RSS0680 is a protein kinase degrader that degrades a variety of kinases and can be used to study diseases caused by kinase abnormalities.
T7535	RGX-202	353-09-3	98%
T7535	RGX-202 (β-GPA) is a creatine analog that alters skeletal muscle energy expenditure. It reduces cellular ATP, creatine, and phosphocreatine levels and stimulates...
T5793	Britannin	33627-28-0	98%
T5793	Britannin, a sesquiterpene lactone, inhibits proliferation and induces apoptosis through the mitochondrial signaling pathway in human breast cancer cells.
T7327	7-Methoxyisoflavone	1621-56-3	98%
T7327	7-Methoxyisoflavone is an activator of adenosine monophosphate-activated protein kinase (AMPK).
T3676	Sesamol	533-31-3	98%
T3676	Sesamol (1,3-Benzodioxol-5-ol) could decrease lung inflammation and lipopolysaccharide (LPS)-induced lung injury in rats. Sesamol ameliorates inflammatory and ox...