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AMPK

AMPK (AMP-activated protein kinase) is an enzyme that plays a role in cellular energy homeostasis. It consists of three proteins (subunits) that together make a functional enzyme. The net effect of AMPK activation is stimulation of hepatic fatty acid oxidation andketogenesis, inhibition of cholesterol synthesis, lipogenesis, and triglyceride synthesis, inhibition of adipocyte lipolysis and lipogenesis, stimulation of skeletal muscle fatty acid oxidation and muscle glucose uptake by pancreatic beta-cells. AMPK acts as a metabolic master switch regulating several intracellular systems including the cellular uptake of glucose, the β-oxidation of fatty acids and the biogenesis of glucose transporter 4 (GLUT4) and mitochondria.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
TN2097 Pomolic acid 13849-91-7 96.84%
Pomolic acid
Pomolic acid has anti-cancer, anti-inflammatory and apoptotic activities, it can induce apoptosis in SK-OV-3 cells, which is mediated by the mitochondrial-mediat...
T60122 Aldometanib 2904601-67-6 100%
Aldometanib
Aldometanib (LXY-05-029) is an orally active aldolase inhibitor. Aldometanib prevents FBP from binding to v-ATPase-associated aldolase and activates lysosomal AM...
T73350 BAY-3827 2377576-35-5 100%
BAY-3827
BAY-3827 is a potent and selective AMPK inhibitor with potential antitumor activity, showing antiproliferative activity in an androgen-dependent prostate cancer ...
T6291 WZ4003 1214265-58-3 100%
WZ4003
WZ4003, a highly selective NUAK kinase inhibitor, is with IC50 of 20 nM and 100 nM for NUAK1 and NUAK2, respectively. It is no significant inhibition on 139 othe...
TP2312 MOTS-c(Human) Acetate(1627580-64-6 free) TP2312 100%
MOTS-c(Human) Acetate(1627580-64-6 free)
MOTS-c(Human) Acetate is a mitochondrial-derived peptide. MOTS-c(human) acetate induces the accumulation of AMP analog AICAR, increases activation of AMPK and ex...
T10789 Chitosan oligosaccharide 148411-57-8
Chitosan oligosaccharide
Chitosan oligosaccharide (COS) is an oligomer of β-(1→4)-linked D-glucosamine. It has the ability to activate AMPK and simultaneously inhibit inflammatory signal...
T2978 Mogroside V 88901-36-4
Mogroside V
Mogroside V is a widely used sweetener, has in vitro AMPK activating effect, it also has anti-inflammatory potential in murine macrophages and a murine ear edema...
TN6751 1-HEXACOSANOL 506-52-5
1-HEXACOSANOL
Hexacosanol activates AMPK and hepatic autophagy and inhibits SREBP2, resulting in hypocholesterolemic activities and improvement of hepatic steatosis.
T2750 Ginkgolide C 15291-76-6
Ginkgolide C
Ginkgolide C (BN-52022), a natural product, can enhance the cardiac function of rats in the body.
T7362 O-304 1261289-04-6
O-304
O-304 is a pan-activator of AMP-activated protein kinase (AMPK).
T1453 Phenformin hydrochloride 834-28-6 98%
Phenformin hydrochloride
Phenformin hydrochloride (Phenformin HCl) is an agent belonging to the biguanide class of antidiabetics with antihyperglycemic activity.
T60675L AMPK activator 2 hydrochloride( 2410961-69-0 Free base) 98%
AMPK activator 2  hydrochloride( 2410961-69-0  Free base)
AMPK activator 2 hydrochloride is a fluoroguanidine-containing derivative that up-regulates the AMPK signaling pathway and down-regulates mTOR/4EBP1/p70S6K.AMPK ...
T16099 MK8722 1394371-71-1 98%
MK8722
MK8722 is an effective and systemic activator of pan-AMPK.
T41162 ZLN 024 hydrochloride 1883548-91-1 98%
ZLN 024 hydrochloride
ZLN 024 hydrochloride is an AMPK allosteric activator and stimulates the inactive α1 subunit truncations α1 (1-394) and α1 (1-335) but not α1 (1-312).
T74643 RSS0680 2769753-48-0 98%
RSS0680
RSS0680 is a protein kinase degrader that degrades a variety of kinases and can be used to study diseases caused by kinase abnormalities.
T14149 AICAR phosphate 681006-28-0 98%
AICAR phosphate
AICAR phosphate (Acadesine phosphate) is an AMPK activator and inhibitor of autophagy, YAP, and mitophagy, as well as an adenosine analog that regulates glucose ...
T5793 Britannin 33627-28-0 98%
Britannin
Britannin, a sesquiterpene lactone, inhibits proliferation and induces apoptosis through the mitochondrial signaling pathway in human breast cancer cells.
T3676 Sesamol 533-31-3 98%
Sesamol
Sesamol (1,3-Benzodioxol-5-ol) could decrease lung inflammation and lipopolysaccharide (LPS)-induced lung injury in rats. Sesamol ameliorates inflammatory and ox...
T13173 TMPA 1258275-73-8 98%
TMPA
TMPA is a nuclear receptor Nur77 and LKB1 interaction antagonist.
Pomolic acid
TN2097
Pomolic acid has anti-cancer, anti-inflammatory and apoptotic activities, it can induce apoptosis in SK-OV-3 cells, which is mediated by the mitochondrial-mediat...
Aldometanib
T60122
Aldometanib (LXY-05-029) is an orally active aldolase inhibitor. Aldometanib prevents FBP from binding to v-ATPase-associated aldolase and activates lysosomal AM...
BAY-3827
T73350
BAY-3827 is a potent and selective AMPK inhibitor with potential antitumor activity, showing antiproliferative activity in an androgen-dependent prostate cancer ...
WZ4003
T6291
WZ4003, a highly selective NUAK kinase inhibitor, is with IC50 of 20 nM and 100 nM for NUAK1 and NUAK2, respectively. It is no significant inhibition on 139 othe...
MOTS-c(Human) Acetate(1627580-64-6 free)
TP2312
MOTS-c(Human) Acetate is a mitochondrial-derived peptide. MOTS-c(human) acetate induces the accumulation of AMP analog AICAR, increases activation of AMPK and ex...
Chitosan oligosaccharide
T10789
Chitosan oligosaccharide (COS) is an oligomer of β-(1→4)-linked D-glucosamine. It has the ability to activate AMPK and simultaneously inhibit inflammatory signal...
Mogroside V
T2978
Mogroside V is a widely used sweetener, has in vitro AMPK activating effect, it also has anti-inflammatory potential in murine macrophages and a murine ear edema...
1-HEXACOSANOL
TN6751
Hexacosanol activates AMPK and hepatic autophagy and inhibits SREBP2, resulting in hypocholesterolemic activities and improvement of hepatic steatosis.
Ginkgolide C
T2750
Ginkgolide C (BN-52022), a natural product, can enhance the cardiac function of rats in the body.
O-304
T7362
O-304 is a pan-activator of AMP-activated protein kinase (AMPK).
Phenformin hydrochloride
T1453
Phenformin hydrochloride (Phenformin HCl) is an agent belonging to the biguanide class of antidiabetics with antihyperglycemic activity.
AMPK activator 2 hydrochloride( 2410961-69-0 Free base)
T60675L
AMPK activator 2 hydrochloride is a fluoroguanidine-containing derivative that up-regulates the AMPK signaling pathway and down-regulates mTOR/4EBP1/p70S6K.AMPK ...
MK8722
T16099
MK8722 is an effective and systemic activator of pan-AMPK.
ZLN 024 hydrochloride
T41162
ZLN 024 hydrochloride is an AMPK allosteric activator and stimulates the inactive α1 subunit truncations α1 (1-394) and α1 (1-335) but not α1 (1-312).
RSS0680
T74643
RSS0680 is a protein kinase degrader that degrades a variety of kinases and can be used to study diseases caused by kinase abnormalities.
AICAR phosphate
T14149
AICAR phosphate (Acadesine phosphate) is an AMPK activator and inhibitor of autophagy, YAP, and mitophagy, as well as an adenosine analog that regulates glucose ...
Britannin
T5793
Britannin, a sesquiterpene lactone, inhibits proliferation and induces apoptosis through the mitochondrial signaling pathway in human breast cancer cells.
Sesamol
T3676
Sesamol (1,3-Benzodioxol-5-ol) could decrease lung inflammation and lipopolysaccharide (LPS)-induced lung injury in rats. Sesamol ameliorates inflammatory and ox...
TMPA
T13173
TMPA is a nuclear receptor Nur77 and LKB1 interaction antagonist.
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TargetMol