COX

Cyclooxygenase (COX), officially known as prostaglandin-endoperoxide synthase (PTGS), is an enzyme (specifically, a family of isozymes) that is responsible for formation of prostanoids, including thromboxane and prostaglandins such as prostacyclin, from arachidonic acid. A member of the animal-type heme peroxidase family, it is also known as prostaglandin G/H synthase.

Cat. No.	Product name	CAS No.	Purity
T3P2855	Chamigrenal	19912-84-6
T3P2855	β-Chamigrenal has anti-inflammatory activity, it has inhibitory effects on lipopolysaccharide-induced nitric oxide and prostaglandin E2 production in RAW 264.7 m...
TN1660	Ganoderic acid C1	95311-97-0
TN1660	Ganoderic acid C1 has anti-inflammatory activity, has potential for treating TNF-α± mediated inflammation in asthma and other inflammatory diseases. Ganoderic ac...
TN4592	Murrangatin	37126-91-3	98%
TN4592	Murrangatin may be a valuable anti-tumor-promoting agent, it can significantly inhibit Epstein-Barr virus early antigen (EBV-EA) activation, and preserve the hig...
TN5248	Voleneol	70389-88-7	98%
TN5248	1β,6α-Dihydroxyeudesm-4(15)-ene (Voleneol,DE) can attenuate the lipopolysaccharide (LPS)-induced inflammation in BV2 microglial cells, it also can dose-dependent...
T12800	(S)-(+)-Ibuprofen D3	1329643-44-8	98%
T12800	(S)-(+)-Ibuprofen D3 is a deuterium labeled (S)-(+)-Ibuprofen. (S)-(+)-Ibuprofen is the S(+)-enantiomer of Ibuprofen ,it is an inhibitor of COX-1 and COX-2 activ...
TN3366	Ailanthoidol	156398-61-7	98%
TN3366	Ailanthoidol has anti-inflammatory activity, it inhibits inflammatory reactions by macrophages and protects mice from endotoxin shock. It also possesses potentia...
TN1694	Gliotoxin	67-99-2	98%
TN1694	Gliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signalin...
TN4938	Samidin	477-33-8	98%
TN4938	Samidin has anti-inflammatory properties through suppression of NF-ÎºB and AP-1-mediated-genes in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells.
T78705	COX-2-IN-30	1160498-08-7	98%
T78705	COX-2-IN-30, a benzenesulfonamide derivative, is an orally active, dual inhibitor of cyclooxygenase-2 (COX-2; IC50 = 49 nM) and cyclooxygenase-1 (COX-1; IC50 = 1...
T78706	COX-2-IN-31		98%
T78706	COX-2-IN-31 (compound 7b) is an orally active dual inhibitor targeting COX-2 (IC50=60 nM) and 5-LOX (IC50=1.9 μM). Additionally, it inhibits the activity of tran...
T78754	COX-2-IN-33		98%
T78754	COX-2-IN-33 (compound 5f) is a selective COX-2 inhibitor with an IC50 value of 45.5 nM and exhibits potential as an anti-inflammatory agent. It effectively suppr...
T79592	COX-1/2-IN-4		98%
T79592	COX-1/2-IN-4 (compound 2b) is a dual COX-1 and COX-2 inhibitor with respective IC50 values of 0.239 μM for COX-1 and 0.191 μM for COX-2. Additionally, it demonst...
T79594	COX-1/2-IN-5		98%
T79594	COX-1/2-IN-5 (compound 2a) functions as a dual inhibitor of COX1/2, demonstrating inhibitory concentrations (IC50) of 2.650 μM and 0.958 μM, respectively, and ex...
T79598	Anti-inflammatory agent 52		98%
T79598	Anti-inflammatory agent 52 (compound 7j) is an orally active, selective COX-2 inhibitor with the capability to induce G2/M phase arrest and exhibit anti-HT29 tra...
T79599	Anti-inflammatory agent 53		98%
T79599	Anti-inflammatory agent 52 (compound 7c) is an orally active, selective COX-2 inhibitor with demonstrated anti-HT29 metastatic activity, causing periodic arrest ...
T79670	Anti-inflammatory agent 56	2413127-32-7	98%
T79670	Anti-inflammatory agent 56 (Compound 9), a selective COX-2 inhibitor with an IC50 of 0.54 μM, exhibits anti-oxidant and anti-inflammatory properties by inhibitin...
T79760	COX-2-IN-35		98%
T79760	COX-2-IN-35 (compound 7) is a selective inhibitor of COX-2, demonstrating anti-inflammatory activity, with an inhibitory concentration (IC 50) of 4.37 nM [1].
T79915	Antioxidant agent-15	596-38-3	98%
T79915	Antioxidant agent-15 (Compound 4) demonstrates potent antioxidant inhibition activity, exhibiting an IC50 value of 15.44 nM. Furthermore, it effectively inhibits...
T79944	2-O-Sinapoyl makisterone A		98%
T79944	Compound 2, formally known as 2-O-Sinapoyl makisterone A, is a sinapinic acid-ecdysterone hybrid that acts as a selective inhibitor of COX-2, effectively suppres...
TN4465	Luvangetin	483-92-1	98%
TN4465	Luvangetin may have anti-inflammatory activity, it can inhibit NO and PGE2 production in LPS-stimulated BV2 cells. Luvangetin shows significant protection agains...