COX

Cyclooxygenase (COX), officially known as prostaglandin-endoperoxide synthase (PTGS), is an enzyme (specifically, a family of isozymes) that is responsible for formation of prostanoids, including thromboxane and prostaglandins such as prostacyclin, from arachidonic acid. A member of the animal-type heme peroxidase family, it is also known as prostaglandin G/H synthase.

Cat. No.	Product name	CAS No.	Purity
T2405	Revaprazan hydrochloride	178307-42-1	99.64%
T2405	Revaprazan hydrochloride (YH1885) is the hydrochloride salt form of a lipophilic, weak base with potassium-competitive acid blocking (P-CAB) activity.
T22790	FR 122047	130717-51-0	99.63%
T22790	FR 122047 (1-[(4,5-Bis(4-methoxyphenyl-2-thiazoyl)carbonyl]-4-methylpiperazine, Hydrochloride) is a potent and selective inhibitor of COX-1 with IC50 of 28 nM an...
T9042	Teriflunomide impurity 3	1011244-72-6	99.62%
T9042	Teriflunomide impurity 3 (4-Amino-N-(4-trifluoromethylphenyl)benzamide) is a selective COX-1 inhibitor(IC50 of 30 μM). It is less active against COX-2 (IC50>100 ...
TN1723	Hamaudol	735-46-6	99.62%
TN1723	Hamaudol is a chromone isolated from Saposhnikovia divaricata,has analgesic and anti-inflammary activities, it showed inhibitory activity on COX-1 and COX-2 acti...
T0705	Triflusal	322-79-2	99.61%
T0705	Triflusal (UR1501) is a 2-acetoxy-4-trifluoromethylbenzoic acid and it is an aspirin chemically-related molecule but not a derivative.
TN1273	7,4'-Dihydroxyflavone	2196-14-7	99.6%
TN1273	7,4'-Dihydroxyflavone (4',7-Dihydroxyflavone) can induce transcription of nodulation (nod) genes in Rhizobium meliloti. It has inhibitory activities against COX-...
T0758	Piroxicam	36322-90-4	99.59%
T0758	Piroxicam (CP-16171) is a non-specific COX inhibitor.
TN1377	α-Spinasterol	481-18-5	99.58%
TN1377	α-Spinasterol is a transient receptor potential vanilloid 1 (TRPV1) antagonist, has anti-inflammatory, antidepressant, antioxidant and antinociceptive effects. α...
T0498	Salsalate	552-94-3	99.57%
T0498	Salsalate (Sasapyrine) is an orally available salicylate and non-steroidal anti-inflammatory drug (NSAID), with anti-inflammatory, analgesic and antipyretic acti...
T0319	Suxibuzone	27470-51-5	99.56%
T0319	Suxibuzone (Suxibuzona) is a drug used for joint and muscular pain. It is a prodrug of the non steroidal anti inflammatory drug phenylbutazone, and is commonly u...
T0477	Zileuton	111406-87-2	99.56%
T0477	Zileuton (A 64077) is a synthetic derivative of hydroxyurea with antiasthmatic properties. The leukotriene inhibitor zileuton blocks 5-lipoxygenase, which cataly...
T62061	COX-2-IN-6	2756347-91-6	99.56%
T62061	COX-2-IN-6 is a potent, selective, and orally available cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 0.84 μM and a Ki of 69 nM.COX-2-IN-6 inhibits COX-2-dr...
TN3500	Beta-Amyrone	638-97-1	99.55%
TN3500	beta-Amyrone (β-Amyron) has antifungal activity against Chikungunya virus replication with an EC50 of 86 uM. beta-Amyrone has anti-inflammatory activity through ...
T0888	Felbinac	5728-52-9	99.55%
T0888	Felbinac (Dapson), a topical medicine, is an active metabolite of fenbufen. It is belonging to the family of medicines known as non-steroidal anti-inflammatory d...
T2758	Madecassic acid	18449-41-7	99.55%
T2758	Madecassic acid (L-fucopyranose) is extracted from the whole herb of Centella asiatica.
T0212	Seratrodast	112665-43-7	99.54%
T0212	Seratrodast (ABT-001) (INN), a thromboxane A2 (TXA2) receptor (TP receptor) antagonist, is mainly used in the therapy of asthma. It was the first TP receptor ant...
T0798	Triamcinolone	124-94-7	99.54%
T0798	Triamcinolone (Aristocort) is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. Upon cell entry, triamcinolone binds to and acti...
T3805	Prim-O-glucosylcimifugin	80681-45-4	99.54%
T3805	Prim-O-glucosylcimifugin (Cimifugin 7-glucoside) can inhibit the proliferation of SMC(smooth muscle cell) stimulated by TNF-alpha, increase the proportion of G0/...
T1468	Lornoxicam	70374-39-9	99.53%
T1468	Lornoxicam (Chlortenoxicam) (chlortenoxicam) is a new nonsteroidal anti-inflammatory drug (NSAID) of the oxicam class with analgesic, anti-inflammatory, and anti...
T0459	Sulindac	38194-50-2	99.49%
T0459	Sulindac (Sulindac sulfoxide) is a sulfinylindene derivative prodrug with potential antineoplastic activity. Converted in vivo to an active metabolite, sulindac,...