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COX

Cyclooxygenase (COX), officially known as prostaglandin-endoperoxide synthase (PTGS), is an enzyme (specifically, a family of isozymes) that is responsible for formation of prostanoids, including thromboxane and prostaglandins such as prostacyclin, from arachidonic acid. A member of the animal-type heme peroxidase family, it is also known as prostaglandin G/H synthase.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T6568 Licofelone 156897-06-2 99.49%
Licofelone
Licofelone (ML-3000) is a dual COX/LOX inhibitor potentially for the treatment of osteoarthritis. Licofelone is both an analgesic and an anti-inflammatory. Inhib...
T12860 SC57666 158959-32-1 99.48%
SC57666
SC57666 is a highly selective COX2 inhibitor (IC50 at 26 nM) that shows no activity against COX1.
T1325 Carprofen 53716-49-7 99.45%
Carprofen
Carprofen (Ridamyl) is a propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic activities.
T0436 6-Acetamidohexanoic acid 57-08-9 99.45%
6-Acetamidohexanoic acid
6-Acetamidohexanoic acid (Acexamic Acid) is a kind of amino acids deriviate.
TQ0288 Hexahydrocurcumin 36062-05-2 99.43%
Hexahydrocurcumin
Hexahydrocurcumin is a selective, orally active COX-2 inhibitor and inactive against COX-1.
T7113 Paradol 27113-22-0 99.43%
Paradol
Paradol ([6]-Gingerone) is a pungent phenolic substance found in ginger and other Zingiberaceae plants, and exhibits a variety of biological activities including...
T0808 Diflunisal 22494-42-4 99.42%
Diflunisal
Diflunisal (Dolobid) is a cyclooxygenase (COX) Inhibitor, used as an anti-inflammatory analgesic.
T21412 Ketorolac 74103-06-3 99.4%
Ketorolac
Ketorolac (Acuvail) is a non-steroidal anti-inflammatory drug (NSAID) in the family of heterocyclic acetic acid derivatives. It acts by inhibiting the bodily syn...
TN2139 Regaloside B 114420-67-6 99.4%
Regaloside B
Regaloside B, a phenylpropanoid isolated from Lilium longiflorum, exhibits anti-inflammatory activity by inhibiting the expression of iNOS (inducible nitric oxid...
T8293 γ-Tocopherol 54-28-4 99.39%
γ-Tocopherol
(+)-γ-Tocopherol ((+)-γ-Tocopherol) is one of the naturally occurring forms of Vitamin E. It is the most abundant Tocopherol in soybean and corn oils.
T83628 TNF/IFNγ-IN-1 876013-29-5 99.39%
TNF/IFNγ-IN-1
TNF/IFNγ-IN-1 (TGA) is a dual inhibitor of TNF and IFN-γ. TNF/IFNγ-IN-1 has potential antioxidant and anti-inflammatory activities for neurodegenerative diseases...
T4101 SC-560 188817-13-2 99.39%
SC-560
SC-560 is a member of the diaryl heterocycle class of cyclooxygenase (COX) inhibitors.
T0825 Ebselen 60940-34-3 99.38%
Ebselen
Ebselen (CCG-39161) is a organoselenium compound with anti-inflammatory, anti-oxidant and cytoprotective activity. Ebselen acts as a glutathione peroxidase mimet...
T16329 Nitroflurbiprofen 158836-71-6 99.38%
Nitroflurbiprofen
Nitroflurbiprofen (Nitroxybutyl flurbiprofen) is a NO-releasing COX inhibitor and modulates the increased intrahepatic vascular tone in portal hypertensive cirrh...
T12933 SM-276001 473930-22-2 99.37%
SM-276001
SM-276001 is a potent selective agonist of TLR7,and is an orally active interferon (IFN) inducer.
T2225 4-Hydroxyantipyrine 1672-63-5 99.37%
4-Hydroxyantipyrine
4-Hydroxyantipyrine is formed during oxidative deamination of aminopyrine.
T7670 Mavacoxib 170569-88-7 99.36%
Mavacoxib
Mavacoxib is a selective inhibitor of cyclooxygenase-2 (COX-2) ,with Anti-Tumour activity.
T3954 Adelmidrol 1675-66-7 99.35%
Adelmidrol
Adelmidrol is an anti-inflammatory ethanolamide derivative of azelaic acid.
T22398 Phenidone 92-43-3 99.34%
Phenidone
Phenidone (1-phenyl-3-pyrazolidinone) is a dual inhibitor of cyclooxygenases and lipoxygenases that ameliorates rat paralysis in experimental autoimmune encephal...
T5807 Stylopine hydrochloride 96087-21-7 99.34%
Stylopine hydrochloride
Stylopine is a protoberberine-type alkaloid that has potential biological activities, including anti-inflammatory activity.
Licofelone
T6568
Licofelone (ML-3000) is a dual COX/LOX inhibitor potentially for the treatment of osteoarthritis. Licofelone is both an analgesic and an anti-inflammatory. Inhib...
SC57666
T12860
SC57666 is a highly selective COX2 inhibitor (IC50 at 26 nM) that shows no activity against COX1.
Carprofen
T1325
Carprofen (Ridamyl) is a propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic activities.
6-Acetamidohexanoic acid
T0436
6-Acetamidohexanoic acid (Acexamic Acid) is a kind of amino acids deriviate.
Hexahydrocurcumin
TQ0288
Hexahydrocurcumin is a selective, orally active COX-2 inhibitor and inactive against COX-1.
Paradol
T7113
Paradol ([6]-Gingerone) is a pungent phenolic substance found in ginger and other Zingiberaceae plants, and exhibits a variety of biological activities including...
Diflunisal
T0808
Diflunisal (Dolobid) is a cyclooxygenase (COX) Inhibitor, used as an anti-inflammatory analgesic.
Ketorolac
T21412
Ketorolac (Acuvail) is a non-steroidal anti-inflammatory drug (NSAID) in the family of heterocyclic acetic acid derivatives. It acts by inhibiting the bodily syn...
Regaloside B
TN2139
Regaloside B, a phenylpropanoid isolated from Lilium longiflorum, exhibits anti-inflammatory activity by inhibiting the expression of iNOS (inducible nitric oxid...
γ-Tocopherol
T8293
(+)-γ-Tocopherol ((+)-γ-Tocopherol) is one of the naturally occurring forms of Vitamin E. It is the most abundant Tocopherol in soybean and corn oils.
TNF/IFNγ-IN-1
T83628
TNF/IFNγ-IN-1 (TGA) is a dual inhibitor of TNF and IFN-γ. TNF/IFNγ-IN-1 has potential antioxidant and anti-inflammatory activities for neurodegenerative diseases...
SC-560
T4101
SC-560 is a member of the diaryl heterocycle class of cyclooxygenase (COX) inhibitors.
Ebselen
T0825
Ebselen (CCG-39161) is a organoselenium compound with anti-inflammatory, anti-oxidant and cytoprotective activity. Ebselen acts as a glutathione peroxidase mimet...
Nitroflurbiprofen
T16329
Nitroflurbiprofen (Nitroxybutyl flurbiprofen) is a NO-releasing COX inhibitor and modulates the increased intrahepatic vascular tone in portal hypertensive cirrh...
SM-276001
T12933
SM-276001 is a potent selective agonist of TLR7,and is an orally active interferon (IFN) inducer.
4-Hydroxyantipyrine
T2225
4-Hydroxyantipyrine is formed during oxidative deamination of aminopyrine.
Mavacoxib
T7670
Mavacoxib is a selective inhibitor of cyclooxygenase-2 (COX-2) ,with Anti-Tumour activity.
Adelmidrol
T3954
Adelmidrol is an anti-inflammatory ethanolamide derivative of azelaic acid.
Phenidone
T22398
Phenidone (1-phenyl-3-pyrazolidinone) is a dual inhibitor of cyclooxygenases and lipoxygenases that ameliorates rat paralysis in experimental autoimmune encephal...
Stylopine hydrochloride
T5807
Stylopine is a protoberberine-type alkaloid that has potential biological activities, including anti-inflammatory activity.
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TargetMol