COX

Cyclooxygenase (COX), officially known as prostaglandin-endoperoxide synthase (PTGS), is an enzyme (specifically, a family of isozymes) that is responsible for formation of prostanoids, including thromboxane and prostaglandins such as prostacyclin, from arachidonic acid. A member of the animal-type heme peroxidase family, it is also known as prostaglandin G/H synthase.

Cat. No.	Product name	CAS No.	Purity
T15645	Pamicogrel	101001-34-7	98.96%
T15645	Pamicogrel (KBT3022) is an inhibitor of COX.
T12784	RWJ 63556	190967-35-2	98.91%
T12784	RWJ 63556 is an orally active inhibitor of COX-2 selective/5-lipoxygenase, shows anti-inflammatory activities.
T1258	Nabumetone	42924-53-8	98.91%
T1258	Nabumetone (BRL14777)(BRL14777) is a non-steroidal anti-inflammatory drug and its active metabolite 6MNA inhibits the enzymes cyclo-oxygenase I and II.
T4S2126	Ginkgetin	481-46-9	98.91%
T4S2126	1. Ginkgetin has anti-influenza virus and anti-fungal activities. 2. Ginkgetin has anti-inflammatory activity, can down-regulates COX-2 induction in vivo against...
T10032	COX-2-IN-2	134729-13-8	98.85%
T10032	COX-2-IN-2, a selective inducible COX2 inhibitor, exhibits potent inhibition with an IC50 of 0.24 μM. Meanwhile, COX-2-IN-1 functions as an anti-inflammatory age...
T6S0722	Isoorientin	4261-42-1	98.84%
T6S0722	Isoorientin (Homoorientin) has antioxidant activity.
T4092	AG126	118409-62-4	98.72%
T4092	AG126 (Tyrphostin AG126) selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42) at 25-50 μM. It blocks the production of TNF-α in vitro2 and in vi...
T16817	S-2474	158089-95-3	98.72%
T16817	S-2474 is an inhibitor of COX-2 and 5-lipoxygenase (IC50s: 11 nM and 27 μM for COX-2 and COX-1 in human intact cells).
T68136	(Iso)-Samixogrel	133276-52-5	98.67%
T68136	(Iso)-Samixogrel shows activity against Carbonic anhydrase and Cyclooxygenase 2.
T6677	Sophocarpine	6483-15-4	98.67%
T6677	Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.
T6S0413	Pectolinarigenin	520-12-7	98.67%
T6S0413	1. Pectolinarigenin (Pectolinaringenin) exhibits hepatoprotective activity mainly via SOD antioxidant mechanism. 2. Pectolinarigenin possesses anti-inflammatory ...
TN1579	Dihydrocucurbitacin B	13201-14-4	98.67%
TN1579	Dihydrocucurbitacin B (23,24-dihydrocucurbitacin B) is isolated from the roots of Cayaponia tayuya with anti-cancer activity.
TN1291	7,3',4'-Tri-O-methylluteolin	29080-58-8	98.66%
TN1291	7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone) has anti-inflammatory, antibacterial and antifungal activities, it also shows moderate antitry...
T5431	[10]-Shogaol	36752-54-2	98.62%
T5431	[10]-Shogaol (10-Shogaol) is an extract from ginger displaying antioxidant activity. It also may contain hypolipidemic and insulin-sensitizing effects.
T62061	COX-2-IN-6	2756347-91-6	98.62%
T62061	COX-2-IN-6 is a potent, selective, and orally available cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 0.84 μM and a Ki of 69 nM.COX-2-IN-6 inhibits COX-2-dr...
T7081	CCCP	555-60-2	98.55%
T7081	CCCP (Carbonyl Cyanide m-Chlorophenylhydrazone) is an oxidative phosphorylation (OXPHOS) inhibitor and mitochondrial proton carrier uncoupler. CCCP inhibits the ...
T3884	Neoandrographolide	27215-14-1	98.52%
T3884	Neoandrographolide (Neoandrographiside) has potent hypolipidemic effect and protects the cardiovascular without significant liver damage.Neoandrographolide has a...
T26109	Robenacoxib	220991-32-2	98.51%
T26109	Robenacoxib (Onsior) is a non-steroidal compound with strong selectivity for cyclooxygenase-2 and anti-inflammatory activity.
T21294	Polmacoxib	301692-76-2	98.49%
T21294	Polmacoxib (CG 100649) is a first-in-class NSAID drug candidate, is a dual inhibitor of carbonic anhydrase (CA) and COX-2. Polmacoxib inhibits premalignant and m...
TN1622	Ermanin	20869-95-8	98.46%
TN1622	Ermanin is a flavonoid isolated from Tanacetum microphyllum.Ermanin inhibits platelet aggregation and has anti-tuberculosis and anti-viral/bacterial properties.E...