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COX

Cyclooxygenase (COX), officially known as prostaglandin-endoperoxide synthase (PTGS), is an enzyme (specifically, a family of isozymes) that is responsible for formation of prostanoids, including thromboxane and prostaglandins such as prostacyclin, from arachidonic acid. A member of the animal-type heme peroxidase family, it is also known as prostaglandin G/H synthase.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
TN1622 Ermanin 20869-95-8 98.46%
Ermanin
Ermanin is a flavonoid isolated from Tanacetum microphyllum.Ermanin inhibits platelet aggregation and has anti-tuberculosis and anti-viral/bacterial properties.E...
T16328 Nitroaspirin 175033-36-0 98.45%
Nitroaspirin
Nitroaspirin (NCX 4016) is a nitric oxide donor and a nitro-derivative of Aspirin, which combines with Nitroaspirin to inhibit cyclooxygenase. Nitroaspirin induc...
TN1524 Continentalic acid 19889-23-7 98.39%
Continentalic acid
Continentalic acid from Aralia continentalis has minimum inhibitory concentrations (MICs) of approximately 8-16 µg/mL against S. aureus, including the Methicilli...
T0859 Fenbufen 36330-85-5 98.35%
Fenbufen
Fenbufen (Lederfen) is a non-steroidal anti-inflammatory drug used primarily to treat inflammation in osteoarthritis, ankylosing spondylitis, and tendinitis. It ...
T0004 Salicylamide 65-45-2 98.33%
Salicylamide
Salicylamide (2-Hydroxybenzamide) is an over-the-counter drug with analgesic and antipyretic properties, which has similar medicinal properties to aspirin. In th...
T0463 Loxoprofen 68767-14-6 98.25%
Loxoprofen
Loxoprofen (Koloxo) is an anti-inflammatory non-steroidal medicine.
T3S0006 (E)-Ferulic acid methyl ester 22329-76-6 98.22%
(E)-Ferulic acid methyl ester
(E)-Ferulic acid methyl ester (Methyl (E)-ferulate) is a possible inhibitor of the mitogen activated phosphor kinase pathway, it could be a potential anti-inflam...
T23403 Sulindac sulfone 59864-04-9 98.19%
Sulindac sulfone
Sulindac sulfone is a metabolite of the nonsteroidal anti-inflammatory drug sulindac.
T125120 Cyclo(L-Pro-L-Val) 2854-40-2 98.18%
Cyclo(L-Pro-L-Val)
Cyclo(L-Pro-L-Val), a 2,5-diketopiperazine extracted from the fruits of Mycobacterium chiliolyticum AZ2 and Mycobacterium leprae, possesses anti-inflammatory act...
T1280 Nepafenac 78281-72-8 98.16%
Nepafenac
Nepafenac (AHR 9434) is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of nepafenac is as a Cyclooxygenase Inhibitor. The chemical classification...
TN6672 Cyclo(L-Phe-L-Pro) 3705-26-8 98.14%
Cyclo(L-Phe-L-Pro)
Cyclo(L-Phe-L-Pro) shows broad-spectrum antibacterial and antifungal activities. Cyclo(L-Phe-L-Pro) exhibits activity against methicillin-resistant S. aureus and...
T6S1652 Benzoylpaeoniflorin 38642-49-8 98.14%
Benzoylpaeoniflorin
1. Benzoylpaeoniflorin is active against cyclooxygenase-1 and cyclooxygenase-2 enzymes.
T36683 Vedaprofen 71109-09-6 98.12%
Vedaprofen
Vedaprofen (PM 150) inhibits COX-1 and reduces prostaglandin H2 synthesis with anti-inflammatory activities. Vedaprofen is an inhibitor of Escherichia coli slidi...
T1423 3-Methylsalicylic acid 83-40-9 98.11%
3-Methylsalicylic acid
3-Methylsalicylic acid (o-Cresotic acid) is a long-acting salicylate derivative with antilipidemic properties. Hydroxytoluic acid has been shown to lower plasma ...
T0435 Sulfinpyrazone 57-96-5 98.1%
Sulfinpyrazone
Sulfinpyrazone (NSC-75925) is a uricosuric drug that is used to reduce the serum urate levels in gout therapy. It lacks anti-inflammatory, analgesic, and diureti...
T77618 COX-2-IN-34 2788578-71-0 98.08%
COX-2-IN-34
COX-2-IN-34 is a selective, orally potent COX-2 inhibitor that shows anti-inflammatory activity without gastric ulcer toxicity during experiments in mice.
T13597 (-)-Catechin 18829-70-4 98.06%
(-)-Catechin
(-)-Catechin ((-)-Cianidanol), an isomer of catechin, inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM.
T0907 Sulfasalazine 599-79-1 98.05%
Sulfasalazine
Sulfasalazine (Azulfidine) is a synthetic salicylic acid derivative with affinity for connective tissues containing elastin and formulated as a prodrug
T5759 S-(+)-Marmesin 13849-08-6 98.00%
S-(+)-Marmesin
S-(+)-Marmesin (marmesin) is a coumarin originally isolated from the mature bark of A. marmelos,exhibiting COX-2/5-LOX dual inhibitory activity.
T8236 RHC 80267 83654-05-1 98%
RHC 80267
RHC 80267 (U-57908) is a selective inhibitor of DAGL (IC50 : 4 μM in canine platelets)
Ermanin
TN1622
Ermanin is a flavonoid isolated from Tanacetum microphyllum.Ermanin inhibits platelet aggregation and has anti-tuberculosis and anti-viral/bacterial properties.E...
Nitroaspirin
T16328
Nitroaspirin (NCX 4016) is a nitric oxide donor and a nitro-derivative of Aspirin, which combines with Nitroaspirin to inhibit cyclooxygenase. Nitroaspirin induc...
Continentalic acid
TN1524
Continentalic acid from Aralia continentalis has minimum inhibitory concentrations (MICs) of approximately 8-16 µg/mL against S. aureus, including the Methicilli...
Fenbufen
T0859
Fenbufen (Lederfen) is a non-steroidal anti-inflammatory drug used primarily to treat inflammation in osteoarthritis, ankylosing spondylitis, and tendinitis. It ...
Salicylamide
T0004
Salicylamide (2-Hydroxybenzamide) is an over-the-counter drug with analgesic and antipyretic properties, which has similar medicinal properties to aspirin. In th...
Loxoprofen
T0463
Loxoprofen (Koloxo) is an anti-inflammatory non-steroidal medicine.
(E)-Ferulic acid methyl ester
T3S0006
(E)-Ferulic acid methyl ester (Methyl (E)-ferulate) is a possible inhibitor of the mitogen activated phosphor kinase pathway, it could be a potential anti-inflam...
Sulindac sulfone
T23403
Sulindac sulfone is a metabolite of the nonsteroidal anti-inflammatory drug sulindac.
Cyclo(L-Pro-L-Val)
T125120
Cyclo(L-Pro-L-Val), a 2,5-diketopiperazine extracted from the fruits of Mycobacterium chiliolyticum AZ2 and Mycobacterium leprae, possesses anti-inflammatory act...
Nepafenac
T1280
Nepafenac (AHR 9434) is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of nepafenac is as a Cyclooxygenase Inhibitor. The chemical classification...
Cyclo(L-Phe-L-Pro)
TN6672
Cyclo(L-Phe-L-Pro) shows broad-spectrum antibacterial and antifungal activities. Cyclo(L-Phe-L-Pro) exhibits activity against methicillin-resistant S. aureus and...
Benzoylpaeoniflorin
T6S1652
1. Benzoylpaeoniflorin is active against cyclooxygenase-1 and cyclooxygenase-2 enzymes.
Vedaprofen
T36683
Vedaprofen (PM 150) inhibits COX-1 and reduces prostaglandin H2 synthesis with anti-inflammatory activities. Vedaprofen is an inhibitor of Escherichia coli slidi...
3-Methylsalicylic acid
T1423
3-Methylsalicylic acid (o-Cresotic acid) is a long-acting salicylate derivative with antilipidemic properties. Hydroxytoluic acid has been shown to lower plasma ...
Sulfinpyrazone
T0435
Sulfinpyrazone (NSC-75925) is a uricosuric drug that is used to reduce the serum urate levels in gout therapy. It lacks anti-inflammatory, analgesic, and diureti...
COX-2-IN-34
T77618
COX-2-IN-34 is a selective, orally potent COX-2 inhibitor that shows anti-inflammatory activity without gastric ulcer toxicity during experiments in mice.
(-)-Catechin
T13597
(-)-Catechin ((-)-Cianidanol), an isomer of catechin, inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM.
Sulfasalazine
T0907
Sulfasalazine (Azulfidine) is a synthetic salicylic acid derivative with affinity for connective tissues containing elastin and formulated as a prodrug
S-(+)-Marmesin
T5759
S-(+)-Marmesin (marmesin) is a coumarin originally isolated from the mature bark of A. marmelos,exhibiting COX-2/5-LOX dual inhibitory activity.
RHC 80267
T8236
RHC 80267 (U-57908) is a selective inhibitor of DAGL (IC50 : 4 μM in canine platelets)
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TargetMol