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COX

Cyclooxygenase (COX), officially known as prostaglandin-endoperoxide synthase (PTGS), is an enzyme (specifically, a family of isozymes) that is responsible for formation of prostanoids, including thromboxane and prostaglandins such as prostacyclin, from arachidonic acid. A member of the animal-type heme peroxidase family, it is also known as prostaglandin G/H synthase.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T0778 Phenacetin 62-44-2 100%
Phenacetin
Phenacetin (Acetophenetidin) is a phenylacetamide that was formerly used in ANALGESICS but nephropathy and METHEMOGLOBINEMIA led to its withdrawal from the marke...
T3866 Macelignan 107534-93-0 100%
Macelignan
Macelignan (Anwuligan) is a lignan isolated from nutmeg with antimicrobial and anticariogenic activity against Streptococcus mutans and other streptococcus speci...
T0463L Loxoprofen sodium 80382-23-6 100%
Loxoprofen sodium
Loxoprofen sodium (CS-600) is an effective and oral sodium inhibitor of COX-1 and COX-2 with IC50 of 6.5 and 13.5 μM, respectively. Loxoprofen sodium works by re...
T0050 Ampyrone 83-07-8 100%
Ampyrone
Ampyrone (4-Aminoantipyrine) is a reagent for glucose determination in the presence of peroxidase and phenol.
T6S2023 Harpagoside 19210-12-9 100%
Harpagoside
1. Harpagoside has anti-inflammatory activity. 2. Harpagoside at 3 mM concentration, shows moderate inhibition of seed germination. 3. Harpagoside can inhibit li...
T0005 Aspirin 50-78-2 100%
Aspirin
Aspirin (Acetylsalicylic Acid) is a potent and selective inhibitor of COX with various pharmacological activities, such as anti-inflammation and pain relief. Asp...
T0448 (S)-(+)-Ibuprofen 51146-56-6 100%
(S)-(+)-Ibuprofen
(S)-(+)-Ibuprofen (Dexibuprofen) , is a non-steroidal anti-inflammatory drug (NSAID), inhibiting cyclooxygenase (COX).
T0484 Deracoxib 169590-41-4 100%
Deracoxib
Deracoxib (SC 46) is a non-steroidal, non-narcotic anti-inflammatory drug. It is also a selective cyclooxygenase-2 inhibitor, and IC50 Value: 70 to 150 μM(inhibi...
T68126 Pemedolac 114716-16-4 100%
Pemedolac
Pemedolac (Dexpemedolac) is a small molecule COX inhibitor used to treat neurological disorders, skin and musculoskeletal disorders.
TJS1779 Protosappanin A 102036-28-2 100%
Protosappanin A
Protosappanin A (PTA) has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IκB/NF-κB inf...
T16950 Sudoxicam 34042-85-8 100%
Sudoxicam
Sudoxicam (4-Hydroxy-2-methyl-N-2-thiazolyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide) is a reversible antagonist of COX with anti-inflammatory, anti-edema,...
T1209 Flunixin meglumine 42461-84-7 100%
Flunixin meglumine
Flunixin meglumine (Banamine) is an effective inhibitor of the enzyme cyclooxygenase with anti-inflammatory and antipyretic activity.
T3682 (-)-Catechin gallate 130405-40-2 100%
(-)-Catechin gallate
(-)-Catechin gallate ((-)-Catechin 3-O-gallate) displays inhibition of 6PGD, IDH. (-)-Catechin gallate ((-)-Catechin 3-O-gallate) displays inhibition of human Be...
T1586 Tenoxicam 59804-37-4 100%
Tenoxicam
Tenoxicam (Tilcotil), an antiinflammatory agent with analgesic and antipyretic properties, is used to treat osteoarthritis and control acute pain.
T15181 DuP-697 88149-94-4 100%
DuP-697
DuP-697 is an irreversible and specific inhibitor of COX-2 with IC50 values of 10 nM and 800 nM for human COX-2 and COX-1. DuP-697 shows antiproliferative activi...
T1582L Naproxen sodium 26159-34-2 100%
Naproxen sodium
Naproxen sodium (Anaprox) is a COX inhibitor for COX-1 and COX-2 with analgesic and antipyretic properties.
T0839 Ketoprofen 22071-15-4 100%
Ketoprofen
Ketoprofen (RP-19583) is a propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic effects. Ket...
T0058 2-Ethoxybenzamide 938-73-8 100%
2-Ethoxybenzamide
2-Ethoxybenzamide (Anovigam) is white or almost-white crystalline powder. Almost odorless. Tasteless. It is widely used as an antipyretic anodyne.
T10033 COX-2-IN-1 787623-48-7 100%
COX-2-IN-1
COX-2-IN-1 is a potent and selective COX-2 inhibitor (IC50: 3.9 μM).
T7207 FK 3311 116686-15-8
FK 3311
FK 3311 (COX-2 Inhibitor V) is a cell permeable and orally available sulfonanilide that acts as a COX-2 inhibitor and non-steroidal anti-inflammatory drug (NSAID...
Phenacetin
T0778
Phenacetin (Acetophenetidin) is a phenylacetamide that was formerly used in ANALGESICS but nephropathy and METHEMOGLOBINEMIA led to its withdrawal from the marke...
Macelignan
T3866
Macelignan (Anwuligan) is a lignan isolated from nutmeg with antimicrobial and anticariogenic activity against Streptococcus mutans and other streptococcus speci...
Loxoprofen sodium
T0463L
Loxoprofen sodium (CS-600) is an effective and oral sodium inhibitor of COX-1 and COX-2 with IC50 of 6.5 and 13.5 μM, respectively. Loxoprofen sodium works by re...
Ampyrone
T0050
Ampyrone (4-Aminoantipyrine) is a reagent for glucose determination in the presence of peroxidase and phenol.
Harpagoside
T6S2023
1. Harpagoside has anti-inflammatory activity. 2. Harpagoside at 3 mM concentration, shows moderate inhibition of seed germination. 3. Harpagoside can inhibit li...
Aspirin
T0005
Aspirin (Acetylsalicylic Acid) is a potent and selective inhibitor of COX with various pharmacological activities, such as anti-inflammation and pain relief. Asp...
(S)-(+)-Ibuprofen
T0448
(S)-(+)-Ibuprofen (Dexibuprofen) , is a non-steroidal anti-inflammatory drug (NSAID), inhibiting cyclooxygenase (COX).
Deracoxib
T0484
Deracoxib (SC 46) is a non-steroidal, non-narcotic anti-inflammatory drug. It is also a selective cyclooxygenase-2 inhibitor, and IC50 Value: 70 to 150 μM(inhibi...
Pemedolac
T68126
Pemedolac (Dexpemedolac) is a small molecule COX inhibitor used to treat neurological disorders, skin and musculoskeletal disorders.
Protosappanin A
TJS1779
Protosappanin A (PTA) has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IκB/NF-κB inf...
Sudoxicam
T16950
Sudoxicam (4-Hydroxy-2-methyl-N-2-thiazolyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide) is a reversible antagonist of COX with anti-inflammatory, anti-edema,...
Flunixin meglumine
T1209
Flunixin meglumine (Banamine) is an effective inhibitor of the enzyme cyclooxygenase with anti-inflammatory and antipyretic activity.
(-)-Catechin gallate
T3682
(-)-Catechin gallate ((-)-Catechin 3-O-gallate) displays inhibition of 6PGD, IDH. (-)-Catechin gallate ((-)-Catechin 3-O-gallate) displays inhibition of human Be...
Tenoxicam
T1586
Tenoxicam (Tilcotil), an antiinflammatory agent with analgesic and antipyretic properties, is used to treat osteoarthritis and control acute pain.
DuP-697
T15181
DuP-697 is an irreversible and specific inhibitor of COX-2 with IC50 values of 10 nM and 800 nM for human COX-2 and COX-1. DuP-697 shows antiproliferative activi...
Naproxen sodium
T1582L
Naproxen sodium (Anaprox) is a COX inhibitor for COX-1 and COX-2 with analgesic and antipyretic properties.
Ketoprofen
T0839
Ketoprofen (RP-19583) is a propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic effects. Ket...
2-Ethoxybenzamide
T0058
2-Ethoxybenzamide (Anovigam) is white or almost-white crystalline powder. Almost odorless. Tasteless. It is widely used as an antipyretic anodyne.
COX-2-IN-1
T10033
COX-2-IN-1 is a potent and selective COX-2 inhibitor (IC50: 3.9 μM).
FK 3311
T7207
FK 3311 (COX-2 Inhibitor V) is a cell permeable and orally available sulfonanilide that acts as a COX-2 inhibitor and non-steroidal anti-inflammatory drug (NSAID...
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TargetMol