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COX

Cyclooxygenase (COX), officially known as prostaglandin-endoperoxide synthase (PTGS), is an enzyme (specifically, a family of isozymes) that is responsible for formation of prostanoids, including thromboxane and prostaglandins such as prostacyclin, from arachidonic acid. A member of the animal-type heme peroxidase family, it is also known as prostaglandin G/H synthase.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T3402 20(S)-Ginsenoside Rg3 14197-60-5
20(S)-Ginsenoside Rg3
20(S)-Ginsenoside Rg3 (Rg3) possess an ability to inhibit the lung metastasis of tumor cells via inhibition of the adhesion and invasion of tumor cells. It inhib...
T1867 Otenaproxesul 1226895-20-0
Otenaproxesul
Otenaproxesul (ATB 346) is a novel hydrogen sulphide-releasing derivative of naproxen with markedly reduced toxicity.
T2230 Paeoniflorin 23180-57-6
Paeoniflorin
Paeoniflorin (Peoniflorin) is a herbal constituent extracted from the root of Paeonia albiflora Pall.
T6687 Suprofen 40828-46-4 98%
Suprofen
Suprofen (Suprol) is an IBUPROFEN-type anti-inflammatory analgesic and antipyretic. It inhibits prostaglandin synthesis and has been proposed as an anti-arthriti...
T0980 Nifenazone 2139-47-1 98%
Nifenazone
Nifenazone (Nicodone) is a pyrazole drug, used in the in the treatment of rheumatic disorders.
T3883 Roburic acid 6812-81-3 98%
Roburic acid
Roburic acid and phenethyl-trans-ferulate inhibit COX-1 and COX-2.
T0867 Bufexamac 2438-72-4 98%
Bufexamac
Bufexamac (Bufexamic acid) is a COX inhibitor for IFN-α release with anti-inflammatory, analgesic, and antipyretic action.
TN2330 Phenethyl ferulate 71835-85-3 98%
Phenethyl ferulate
Phenethyl ferulate (Caffeic Acid 3-Methyl Phenethyl Ester) has chemopreventive properties against chemically induced colon carcinogenesis. It enhances apoptosis ...
T19672 Amtolmetin guacil 87344-06-7 98%
Amtolmetin guacil
Amtolmetin guacil (ST-679) inhibits prostaglandin synthesis and cyclooxygenase. Amtolmetin guacil has similar NSAID properties like tolmetin with additional anal...
T2569 Chlorotrianisene 569-57-3 98%
Chlorotrianisene
Chlorotrianisene (tri-p-anisylchloroethylene) is an orally bioavailable, highly lipophilic, synthetic triphenylethylene (TPE) derivative and selective estrogen r...
T12862 SC58451 168433-84-9 98%
SC58451
SC58451 is a novel potent, orally active and selective COX-2 inhibitor.SC58451 showed anti-inflammatory activity in a rat model of arthritis.
T83628 TNF/IFNγ-IN-1 876013-29-5 98%
TNF/IFNγ-IN-1
TNF/IFNγ-IN-1 (TGA) is a dual inhibitor of TNF and IFN-γ. TNF/IFNγ-IN-1 has potential antioxidant and anti-inflammatory activities for neurodegenerative diseases...
T30937 Cimicoxib 265114-23-6 98%
Cimicoxib
Cimicoxib (UR8880) is a potent and selective inhibitor of COX-2 with anti-inflammatory and analgesic activity.
T6498 Fenoprofen calcium hydrate 71720-56-4 98%
Fenoprofen calcium hydrate
Fenoprofen calcium hydrate (Progesic dihydrate) is a non-steroidal anti-inflammatory drug (NSAID).
T4A2456 Gamabufotalin 465-11-2 98%
Gamabufotalin
1. Gamabufotalin (Gamabufagin) , a major bufadienolide of Chansu, has been used for treatment of COX-2-mediated diseases and cancer therapy due to its desirable ...
TN4583 Moringin 73255-40-0 98%
Moringin
Moringin is an isothiocyanate obtained from myrosinase-mediated hydrolysis of the glucosinolate precursor glucoMoringin present in Moringa oleifera seeds. Moring...
T6574 Lumiracoxib 220991-20-8 98%
Lumiracoxib
Lumiracoxib (Prexige) is a novel, selective COX-2 inhibitor with IC50 and Ki of 0.14 μM and 0.06 μM, exhibits 515-fold selectivity over COX-1. Phase 4.
T0726 Benzydamine hydrochloride 132-69-4 98%
Benzydamine hydrochloride
Benzydamine hydrochloride (AF864), a locally-acting nonsteroidal anti-inflammatory drug, has local anaesthetic and analgesic properties.
T0184 Fenoprofen calcium dihydrate 53746-45-5 98%
Fenoprofen calcium dihydrate
Fenoprofen calcium is a propionic acid derivative that is used as a non-steroidal anti-inflammatory agent.
TC0036 Compound Lup-20(29)-en-3-yl acetate TC0036 98%
Compound Lup-20(29)-en-3-yl acetate
Lupeol acetate, a derivative of Lupeol, inhibits the progression of rheumatoid arthritis by downregulating TNF-α, IL-1β, MCP-1, COX-2, VEGF and granzyme B.
20(S)-Ginsenoside Rg3
T3402
20(S)-Ginsenoside Rg3 (Rg3) possess an ability to inhibit the lung metastasis of tumor cells via inhibition of the adhesion and invasion of tumor cells. It inhib...
Otenaproxesul
T1867
Otenaproxesul (ATB 346) is a novel hydrogen sulphide-releasing derivative of naproxen with markedly reduced toxicity.
Paeoniflorin
T2230
Paeoniflorin (Peoniflorin) is a herbal constituent extracted from the root of Paeonia albiflora Pall.
Suprofen
T6687
Suprofen (Suprol) is an IBUPROFEN-type anti-inflammatory analgesic and antipyretic. It inhibits prostaglandin synthesis and has been proposed as an anti-arthriti...
Nifenazone
T0980
Nifenazone (Nicodone) is a pyrazole drug, used in the in the treatment of rheumatic disorders.
Roburic acid
T3883
Roburic acid and phenethyl-trans-ferulate inhibit COX-1 and COX-2.
Bufexamac
T0867
Bufexamac (Bufexamic acid) is a COX inhibitor for IFN-α release with anti-inflammatory, analgesic, and antipyretic action.
Phenethyl ferulate
TN2330
Phenethyl ferulate (Caffeic Acid 3-Methyl Phenethyl Ester) has chemopreventive properties against chemically induced colon carcinogenesis. It enhances apoptosis ...
Amtolmetin guacil
T19672
Amtolmetin guacil (ST-679) inhibits prostaglandin synthesis and cyclooxygenase. Amtolmetin guacil has similar NSAID properties like tolmetin with additional anal...
Chlorotrianisene
T2569
Chlorotrianisene (tri-p-anisylchloroethylene) is an orally bioavailable, highly lipophilic, synthetic triphenylethylene (TPE) derivative and selective estrogen r...
SC58451
T12862
SC58451 is a novel potent, orally active and selective COX-2 inhibitor.SC58451 showed anti-inflammatory activity in a rat model of arthritis.
TNF/IFNγ-IN-1
T83628
TNF/IFNγ-IN-1 (TGA) is a dual inhibitor of TNF and IFN-γ. TNF/IFNγ-IN-1 has potential antioxidant and anti-inflammatory activities for neurodegenerative diseases...
Cimicoxib
T30937
Cimicoxib (UR8880) is a potent and selective inhibitor of COX-2 with anti-inflammatory and analgesic activity.
Fenoprofen calcium hydrate
T6498
Fenoprofen calcium hydrate (Progesic dihydrate) is a non-steroidal anti-inflammatory drug (NSAID).
Gamabufotalin
T4A2456
1. Gamabufotalin (Gamabufagin) , a major bufadienolide of Chansu, has been used for treatment of COX-2-mediated diseases and cancer therapy due to its desirable ...
Moringin
TN4583
Moringin is an isothiocyanate obtained from myrosinase-mediated hydrolysis of the glucosinolate precursor glucoMoringin present in Moringa oleifera seeds. Moring...
Lumiracoxib
T6574
Lumiracoxib (Prexige) is a novel, selective COX-2 inhibitor with IC50 and Ki of 0.14 μM and 0.06 μM, exhibits 515-fold selectivity over COX-1. Phase 4.
Benzydamine hydrochloride
T0726
Benzydamine hydrochloride (AF864), a locally-acting nonsteroidal anti-inflammatory drug, has local anaesthetic and analgesic properties.
Fenoprofen calcium dihydrate
T0184
Fenoprofen calcium is a propionic acid derivative that is used as a non-steroidal anti-inflammatory agent.
Compound Lup-20(29)-en-3-yl acetate
TC0036
Lupeol acetate, a derivative of Lupeol, inhibits the progression of rheumatoid arthritis by downregulating TNF-α, IL-1β, MCP-1, COX-2, VEGF and granzyme B.
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TargetMol