Cannabinoid Receptor

Cannabinoid receptors are of a class of cell membrane receptors in the G protein-coupled receptor superfamily. As is typical of G protein-coupled receptors, the cannabinoid receptors contain seven transmembrane spanning domains. Cannabinoid receptors are activated by three major groups of ligands: endocannabinoids, produced by the mammillary body;[citation needed] plant cannabinoids (such as cannabidiol, produced by the cannabis plant); and synthetic cannabinoids (such as HU-210). All of the endocannabinoids and phytocannabinoids (plant based cannabinoids) are lipophilic, such as fat soluble compounds.

Cat. No.	Product name	CAS No.	Purity
T9114	β-Caryophyllene	87-44-5	97.31%
T9114	β-Caryophyllene acts as an CB2 receptor agonist.
T1915	AM251	183232-66-8	97.88%
T1915	AM251 is a effective CB1 receptor antagonist (IC50/Ki: 8 /7.49 nM) that displays 306-fold selectivity over CB2 receptors; also effective GPR55 agonist (EC50: 39 ...
T2635	Org 27569	868273-06-7	98%
T2635	Org 27569, an allosteric modulator of cannabinoid CB1 receptor, can induce a CB1 receptor state that is characterized by decreased inverse agonist affinity and e...
T5996	CB1-IN-1	1429239-98-4	98%
T5996	CB1-IN-1 is a peripherally restricted CB1R antagonist, for CB1R and CB2R with Ki of 0.3 nM and 21 nM,respectively.
T7375	A-836339	959746-77-1	98%
T7375	A-836339 acts as a potent cannabinoid receptor full agonist which has a higher affinity for the peripheral CB2 receptor (Ki = 0.64 nM) over the central CB1 recep...
T28468	PSNCBAM-1	877202-74-9	98.18%
T28468	PSNCBAM-1 is a CB1 receptor negative allosteric modulator (EC50 = 0.1 μM) with hypophagic effects in vivo. PSNCBAM-1 can be used for obesity studies.
T2264	AM281	202463-68-1	98.6%
T2264	AM 281, a cannabinoid antagonist, reduces neurologic dysfunction and mortality rate after cecal ligation and puncture in rats.
T7316	LY2828360	1231220-79-3	98.61%
T7316	LY2828360 is a cannabinoid (CB) receptor 2 agonist (Ki = 40.3 nM). It selectively activates CB2 over CB1 in a GTPγS binding assay (EC50s = 20.1 and >100,000 nM, ...
T6755	AM1241	444912-48-5	98.72%
T6755	AM-1241 is a selective cannabinoid CB2 receptor agonist with Ki of 3.4 nM, exhibits 82-fold selectivity over CB1 receptor.
T2S0271	Voacamine	3371-85-5	98.73%
T2S0271	Voacamine is an indole alkaloid. Voacamine exhibits potent cannabinoid CB1 receptor antagonistic activity. Voacamine also inhibits P-glycoprotein (P-gp) action i...
T8975	PSB-SB-487	1399049-81-0	98.78%
T8975	PSB-SB-487 is antagonist of GPR55.
T4453	JD-5037	1392116-14-1	98.87%
T4453	JD-5037 is a novel, peripherally restricted CB1R antagonist with an IC50 of 1.5 nM.
T10696	CB2 modulator 1	666261-80-9	99.02%
T10696	CB2 modulator 1 is a potent CB2 modulator. It can be used for the research for immune disorders, osteoporosis, inflammation, renal ischemia.
T21380	Pravadoline	92623-83-1	99.20%
T21380	Pravadoline is a cannabinoid receptor agonist. Pravadoline inhibited the PGs synthesis in mouse brain and displayed antinociceptive activity in rodents subjected...
TP1901L1	Hemopressin (rat) acetate(568588-77-2 free base)	TP1901L1	99.37%
TP1901L1	Hemopressin (rat) acetate is a nonapeptide derived from the α1-chain of hemoglobin, is originally isolated from rat brain homogenates. Hemopressin is orally acti...
T3530	Otenabant	686344-29-6	99.44%
T3530	Otenabant has been investigated for the treatment of Obesity.
T12307	OMDM-6	616884-67-4	99.49%
T12307	OMDM-6 is a dual agonist of TRPV1(EC50 = 75 nM) and CB1 (Ki = 3.2 μM). OMDM-6 inhibits anandamide cellular uptake with a Ki of 7.0 μM.
T0851	Pregnenolone	145-13-1	99.5%
T0851	Pregnenolone is an endogenous steroid hormone synthesized from cholesterol, used in the treatment of Alzheimer's disease.
T6417	BML-190	2854-32-2	99.51%
T6417	BML-190 is a specific CB2 receptor inverse agonist (Ki: 435 nM), with 50-fold selectivity over CB1 receptor.
T8571	ML-184	794572-10-4	99.53%
T8571	ML-184 is a potent synthetic agonist of GPR55 with EC50 of 0.26 µM.