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Cannabinoid Receptor

Cannabinoid receptors are of a class of cell membrane receptors in the G protein-coupled receptor superfamily. As is typical of G protein-coupled receptors, the cannabinoid receptors contain seven transmembrane spanning domains. Cannabinoid receptors are activated by three major groups of ligands: endocannabinoids, produced by the mammillary body;[citation needed] plant cannabinoids (such as cannabidiol, produced by the cannabis plant); and synthetic cannabinoids (such as HU-210). All of the endocannabinoids and phytocannabinoids (plant based cannabinoids) are lipophilic, such as fat soluble compounds.
Cat. No. Product name CAS No. Purity Chemical Structure
T9114 β-Caryophyllene 87-44-5 97.31%
β-Caryophyllene acts as an CB2 receptor agonist.
T1915 AM251 183232-66-8 97.88%
AM251 is a effective CB1 receptor antagonist (IC50/Ki: 8 /7.49 nM) that displays 306-fold selectivity over CB2 receptors; also effective GPR55 agonist (EC50: 39 ...
T2635 Org 27569 868273-06-7 98%
Org 27569, an allosteric modulator of cannabinoid CB1 receptor, can induce a CB1 receptor state that is characterized by decreased inverse agonist affinity and e...
T5996 CB1-IN-1 1429239-98-4 98%
CB1-IN-1 is a peripherally restricted CB1R antagonist, for CB1R and CB2R with Ki of 0.3 nM and 21 nM,respectively.
T7375 A-836339 959746-77-1 98%
A-836339 acts as a potent cannabinoid receptor full agonist which has a higher affinity for the peripheral CB2 receptor (Ki = 0.64 nM) over the central CB1 recep...
T28468 PSNCBAM-1 877202-74-9 98.18%
PSNCBAM-1 is a CB1 receptor negative allosteric modulator (EC50 = 0.1 μM) with hypophagic effects in vivo. PSNCBAM-1 can be used for obesity studies.
T2264 AM281 202463-68-1 98.6%
AM 281, a cannabinoid antagonist, reduces neurologic dysfunction and mortality rate after cecal ligation and puncture in rats.
T7316 LY2828360 1231220-79-3 98.61%
LY2828360 is a cannabinoid (CB) receptor 2 agonist (Ki = 40.3 nM). It selectively activates CB2 over CB1 in a GTPγS binding assay (EC50s = 20.1 and >100,000 nM, ...
T6755 AM1241 444912-48-5 98.72%
AM-1241 is a selective cannabinoid CB2 receptor agonist with Ki of 3.4 nM, exhibits 82-fold selectivity over CB1 receptor.
T2S0271 Voacamine 3371-85-5 98.73%
Voacamine is an indole alkaloid. Voacamine exhibits potent cannabinoid CB1 receptor antagonistic activity. Voacamine also inhibits P-glycoprotein (P-gp) action i...
T8975 PSB-SB-487 1399049-81-0 98.78%
PSB-SB-487 is antagonist of GPR55.
T4453 JD-5037 1392116-14-1 98.87%
JD-5037 is a novel, peripherally restricted CB1R antagonist with an IC50 of 1.5 nM.
T10696 CB2 modulator 1 666261-80-9 99.02%
CB2 modulator 1 is a potent CB2 modulator. It can be used for the research for immune disorders, osteoporosis, inflammation, renal ischemia.
T21380 Pravadoline 92623-83-1 99.20%
Pravadoline is a cannabinoid receptor agonist. Pravadoline inhibited the PGs synthesis in mouse brain and displayed antinociceptive activity in rodents subjected...
TP1901L1 Hemopressin (rat) acetate(568588-77-2 free base) TP1901L1 99.37%
Hemopressin (rat) acetate is a nonapeptide derived from the α1-chain of hemoglobin, is originally isolated from rat brain homogenates. Hemopressin is orally acti...
T3530 Otenabant 686344-29-6 99.44%
Otenabant has been investigated for the treatment of Obesity.
T12307 OMDM-6 616884-67-4 99.49%
OMDM-6 is a dual agonist of TRPV1(EC50 = 75 nM) and CB1 (Ki = 3.2 μM). OMDM-6 inhibits anandamide cellular uptake with a Ki of 7.0 μM.
T0851 Pregnenolone 145-13-1 99.5%
Pregnenolone is an endogenous steroid hormone synthesized from cholesterol, used in the treatment of Alzheimer's disease.
T6417 BML-190 2854-32-2 99.51%
BML-190 is a specific CB2 receptor inverse agonist (Ki: 435 nM), with 50-fold selectivity over CB1 receptor.
T8571 ML-184 794572-10-4 99.53%
ML-184 is a potent synthetic agonist of GPR55 with EC50 of 0.26 µM.
β-Caryophyllene
T9114
β-Caryophyllene acts as an CB2 receptor agonist.
AM251
T1915
AM251 is a effective CB1 receptor antagonist (IC50/Ki: 8 /7.49 nM) that displays 306-fold selectivity over CB2 receptors; also effective GPR55 agonist (EC50: 39 ...
Org 27569
T2635
Org 27569, an allosteric modulator of cannabinoid CB1 receptor, can induce a CB1 receptor state that is characterized by decreased inverse agonist affinity and e...
CB1-IN-1
T5996
CB1-IN-1 is a peripherally restricted CB1R antagonist, for CB1R and CB2R with Ki of 0.3 nM and 21 nM,respectively.
A-836339
T7375
A-836339 acts as a potent cannabinoid receptor full agonist which has a higher affinity for the peripheral CB2 receptor (Ki = 0.64 nM) over the central CB1 recep...
PSNCBAM-1
T28468
PSNCBAM-1 is a CB1 receptor negative allosteric modulator (EC50 = 0.1 μM) with hypophagic effects in vivo. PSNCBAM-1 can be used for obesity studies.
AM281
T2264
AM 281, a cannabinoid antagonist, reduces neurologic dysfunction and mortality rate after cecal ligation and puncture in rats.
LY2828360
T7316
LY2828360 is a cannabinoid (CB) receptor 2 agonist (Ki = 40.3 nM). It selectively activates CB2 over CB1 in a GTPγS binding assay (EC50s = 20.1 and >100,000 nM, ...
AM1241
T6755
AM-1241 is a selective cannabinoid CB2 receptor agonist with Ki of 3.4 nM, exhibits 82-fold selectivity over CB1 receptor.
Voacamine
T2S0271
Voacamine is an indole alkaloid. Voacamine exhibits potent cannabinoid CB1 receptor antagonistic activity. Voacamine also inhibits P-glycoprotein (P-gp) action i...
PSB-SB-487
T8975
PSB-SB-487 is antagonist of GPR55.
JD-5037
T4453
JD-5037 is a novel, peripherally restricted CB1R antagonist with an IC50 of 1.5 nM.
CB2 modulator 1
T10696
CB2 modulator 1 is a potent CB2 modulator. It can be used for the research for immune disorders, osteoporosis, inflammation, renal ischemia.
Pravadoline
T21380
Pravadoline is a cannabinoid receptor agonist. Pravadoline inhibited the PGs synthesis in mouse brain and displayed antinociceptive activity in rodents subjected...
Hemopressin (rat) acetate(568588-77-2 free base)
TP1901L1
Hemopressin (rat) acetate is a nonapeptide derived from the α1-chain of hemoglobin, is originally isolated from rat brain homogenates. Hemopressin is orally acti...
Otenabant
T3530
Otenabant has been investigated for the treatment of Obesity.
OMDM-6
T12307
OMDM-6 is a dual agonist of TRPV1(EC50 = 75 nM) and CB1 (Ki = 3.2 μM). OMDM-6 inhibits anandamide cellular uptake with a Ki of 7.0 μM.
Pregnenolone
T0851
Pregnenolone is an endogenous steroid hormone synthesized from cholesterol, used in the treatment of Alzheimer's disease.
BML-190
T6417
BML-190 is a specific CB2 receptor inverse agonist (Ki: 435 nM), with 50-fold selectivity over CB1 receptor.
ML-184
T8571
ML-184 is a potent synthetic agonist of GPR55 with EC50 of 0.26 µM.
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