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Cannabinoid Receptor

Cannabinoid receptors are of a class of cell membrane receptors in the G protein-coupled receptor superfamily. As is typical of G protein-coupled receptors, the cannabinoid receptors contain seven transmembrane spanning domains. Cannabinoid receptors are activated by three major groups of ligands: endocannabinoids, produced by the mammillary body;[citation needed] plant cannabinoids (such as cannabidiol, produced by the cannabis plant); and synthetic cannabinoids (such as HU-210). All of the endocannabinoids and phytocannabinoids (plant based cannabinoids) are lipophilic, such as fat soluble compounds.
Cat. No. Product name CAS No. Purity Chemical Structure
T0851 Pregnenolone 145-13-1 98%
Pregnenolone is an endogenous steroid hormone synthesized from cholesterol, used in the treatment of Alzheimer's disease.
T6417 BML-190 2854-32-2 98%
BML-190 is a specific CB2 receptor inverse agonist (Ki: 435 nM), with 50-fold selectivity over CB1 receptor.
T67745 CB2R/FAAH modulator-2 2876918-68-0 98%
CB2R/FAAH modulator-2 (compound 26) is a dual modulator targeting at CB2R and FAAH. CB2R/FAAH modulator-2 acts as a CB2R agonist and FAAH inhibitor, the Ki value...
T8571 ML-184 794572-10-4 98%
ML-184 is a potent synthetic agonist of GPR55 with EC50 of 0.26 µM.
T3S0738 Yangonin 500-62-9 98%
1. Yangonin is a novel CB receptor ligand, it exhibits affinity for the human recombinant CB receptor. 2. Yangonin could be a valuable candidate for the interv...
T5996 CB1-IN-1 1429239-98-4 98%
CB1-IN-1 is a peripherally restricted CB1R antagonist, for CB1R and CB2R with Ki of 0.3 nM and 21 nM,respectively.
T36520 COR659 544450-68-2 98%
COR659 is a GABAB positive allosteric modulator (PAM) . COR659 suppresses alcohol and chocolate self-administration in rats[1]. COR659 apparently exerts its effe...
T16928 SR144528 192703-06-3 98%
SR144528 is an antagonist of the CB2 receptor (Ki = 0.6 nM) and inhibits microsomal ACAT activity (IC50 = 3.6 μM).
T4478 CID 16020046 834903-43-4 98%
CID16020046 is a selective GPR55 antagonist, inhibiting GPR55 constitutive activity with IC50 of 0.15 μM in yeast.
T3699 Bay 59-3074 406205-74-1 98%
Bay 59-3074 is a CB1/CB2 receptor partial agonist (Ki: 48.3/45.5 nM). In rat models of chronic neuropathic and inflammatory pain, it displays anti-hyperalgesic a...
T12306 OMDM-5 616884-66-3 98%
OMDM-5 is a selective anandamide cellular uptake (ACU)inhibitor(Ki of 4.8 μM).
T22114 NESS 0327 494844-07-4 98%
NESS 0327 is a high selectivity antagonist of the cannabinoid CB1 receptor. NESS 0327 is more than 60,000-fold selective for the CB1 receptor.
T3736 Olivetol 500-66-3 98%
Olivetol (5-pentylresorcinol, 5-pentyl-1,3-benzenediol) is an organic compound found in certain species of lichen; it is also a precursor in various syntheses of...
TC0019 Pregnenolone acetate 1778-02-5 98%
Pregnenolone acetate is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. It acts as a signaling-specific inhibi...
T33452 ML192 460331-61-7 98%
ML192 is a selective GPR55 ligand antagonist. ML192 is an inhibitor that inhibits β-arrestin transport, ERK1/2 phosphorylation, and PKCβII translocation.
T1796 Otenabant hydrochloride 686347-12-6 98%
Otenabant hydrochloride (CP-945598) is a competitive, high affinity, selective antagonist of the CB1 receptor (Ki: 0.7 nM).
T22103 ML-193 713121-80-3 98%
ML-193 is a potent and selective GPR55 antagonist( IC50 : 221 nM). It shows more than 27-fold selectivity for GPR55 over GPR35, CB1 and CB2, and can improve the ...
T21861 Drinabant 358970-97-5 98%
Drinabant is an orally active CB1 receptor antagonist. Drinabant inhibits the agonist-stimulated calcium signal with IC50 values of 25 nM and 10 nM for the hCB1-...
T4654 (±)-Ibipinabant 362519-49-1 98%
SLV319 has been used in trials studying the treatment of Obesity and Obesity and Type 2 Diabetes.
TN2268 Tetrahydromagnolol 20601-85-8 98%
Tetrahydromagnolol can activate cannabinoid (CB) receptors.
Pregnenolone
T0851
Pregnenolone is an endogenous steroid hormone synthesized from cholesterol, used in the treatment of Alzheimer's disease.
BML-190
T6417
BML-190 is a specific CB2 receptor inverse agonist (Ki: 435 nM), with 50-fold selectivity over CB1 receptor.
CB2R/FAAH modulator-2
T67745
CB2R/FAAH modulator-2 (compound 26) is a dual modulator targeting at CB2R and FAAH. CB2R/FAAH modulator-2 acts as a CB2R agonist and FAAH inhibitor, the Ki value...
ML-184
T8571
ML-184 is a potent synthetic agonist of GPR55 with EC50 of 0.26 µM.
yangonin
T3S0738
1. Yangonin is a novel CB receptor ligand, it exhibits affinity for the human recombinant CB receptor. 2. Yangonin could be a valuable candidate for the interv...
CB1-IN-1
T5996
CB1-IN-1 is a peripherally restricted CB1R antagonist, for CB1R and CB2R with Ki of 0.3 nM and 21 nM,respectively.
COR659
T36520
COR659 is a GABAB positive allosteric modulator (PAM) . COR659 suppresses alcohol and chocolate self-administration in rats[1]. COR659 apparently exerts its effe...
SR144528
T16928
SR144528 is an antagonist of the CB2 receptor (Ki = 0.6 nM) and inhibits microsomal ACAT activity (IC50 = 3.6 μM).
CID 16020046
T4478
CID16020046 is a selective GPR55 antagonist, inhibiting GPR55 constitutive activity with IC50 of 0.15 μM in yeast.
Bay 59-3074
T3699
Bay 59-3074 is a CB1/CB2 receptor partial agonist (Ki: 48.3/45.5 nM). In rat models of chronic neuropathic and inflammatory pain, it displays anti-hyperalgesic a...
OMDM-5
T12306
OMDM-5 is a selective anandamide cellular uptake (ACU)inhibitor(Ki of 4.8 μM).
NESS 0327
T22114
NESS 0327 is a high selectivity antagonist of the cannabinoid CB1 receptor. NESS 0327 is more than 60,000-fold selective for the CB1 receptor.
Olivetol
T3736
Olivetol (5-pentylresorcinol, 5-pentyl-1,3-benzenediol) is an organic compound found in certain species of lichen; it is also a precursor in various syntheses of...
Pregnenolone acetate
TC0019
Pregnenolone acetate is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. It acts as a signaling-specific inhibi...
ML192
T33452
ML192 is a selective GPR55 ligand antagonist. ML192 is an inhibitor that inhibits β-arrestin transport, ERK1/2 phosphorylation, and PKCβII translocation.
Otenabant hydrochloride
T1796
Otenabant hydrochloride (CP-945598) is a competitive, high affinity, selective antagonist of the CB1 receptor (Ki: 0.7 nM).
ML-193
T22103
ML-193 is a potent and selective GPR55 antagonist( IC50 : 221 nM). It shows more than 27-fold selectivity for GPR55 over GPR35, CB1 and CB2, and can improve the ...
Drinabant
T21861
Drinabant is an orally active CB1 receptor antagonist. Drinabant inhibits the agonist-stimulated calcium signal with IC50 values of 25 nM and 10 nM for the hCB1-...
(±)-Ibipinabant
T4654
SLV319 has been used in trials studying the treatment of Obesity and Obesity and Type 2 Diabetes.
Tetrahydromagnolol
TN2268
Tetrahydromagnolol can activate cannabinoid (CB) receptors.
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