Cannabinoid Receptor

Cannabinoid receptors are of a class of cell membrane receptors in the G protein-coupled receptor superfamily. As is typical of G protein-coupled receptors, the cannabinoid receptors contain seven transmembrane spanning domains. Cannabinoid receptors are activated by three major groups of ligands: endocannabinoids, produced by the mammillary body;[citation needed] plant cannabinoids (such as cannabidiol, produced by the cannabis plant); and synthetic cannabinoids (such as HU-210). All of the endocannabinoids and phytocannabinoids (plant based cannabinoids) are lipophilic, such as fat soluble compounds.

Cat. No.	Product name	CAS No.	Purity
T4478	CID 16020046	834903-43-4	99.59%
T4478	CID 16020046 (C390-0219) is a selective GPR55 antagonist, inhibiting GPR55 constitutive activity with IC50 of 0.15 μM in yeast.
T36520	COR659	544450-68-2	99.56%
T36520	COR659 is a GABAB positive allosteric modulator (PAM) . COR659 suppresses alcohol and chocolate self-administration in rats[1]. COR659 apparently exerts its effe...
T8571	ML-184	794572-10-4	99.53%
T8571	ML-184 (CID2440433) is a potent synthetic agonist of GPR55 with EC50 of 0.26 μM.
T1796	Otenabant hydrochloride	686347-12-6	99.52%
T1796	Otenabant hydrochloride (Otenabant) (CP-945598) is a competitive, high affinity, selective antagonist of the CB1 receptor (Ki: 0.7 nM).
T67745	CB2R/FAAH modulator-2	2876918-68-0	99.52%
T67745	CB2R/FAAH modulator-2 (compound 26) is a dual modulator targeting at CB2R and FAAH. CB2R/FAAH modulator-2 acts as a CB2R agonist and FAAH inhibitor, the Ki value...
T6417	BML-190	2854-32-2	99.51%
T6417	BML-190 (Indomethacin morpholinylamide) is a specific CB2 receptor inverse agonist (Ki: 435 nM), with 50-fold selectivity over CB1 receptor.
T0851	Pregnenolone	145-13-1	99.5%
T0851	Pregnenolone (Arthenolone) is an endogenous steroid hormone synthesized from cholesterol, used in the treatment of Alzheimer's disease.
T1519	Rimonabant hydrochloride	158681-13-1	99.5%
T1519	Rimonabant hydrochloride (SR 141716A) is a cannabinoid receptor antagonist, binding selectively to central cannabinoid receptors (CB1) with high affinity.
T12307	OMDM-6	616884-67-4	99.49%
T12307	OMDM-6 is a dual agonist of TRPV1(EC50 = 75 nM) and CB1 (Ki = 3.2 μM). OMDM-6 inhibits anandamide cellular uptake with a Ki of 7.0 μM.
T41231	GP 1a	511532-96-0	99.44%
T41231	GP 1a is a potent agonist of cannabinoid receptor 2 (CB2) (EC50=7.1), as shown in cAMP, GTPγS and β-arrestin recruitment assays. GP 1a is approximately 30-fold m...
T30252	AZD1940	881413-29-2	99.43%
T30252	AZD1940 (UNII-0J0035E9FT) is a high affinity CB(1)/CB(2) receptor agonist of the cannabinoid with oral activity. Application in the study of orofacial pain.
T23097	O-1602	317321-41-8	99.4%
T23097	O-1602 is a novel GPR55 agonist, an atypical cannabinoid associated with the central nervous system and obesity, and is a candidate compound for the treatment of...
TP1901L1	Hemopressin (rat) acetate(568588-77-2 free base)	TP1901L1	99.37%
TP1901L1	Hemopressin (rat) acetate is a nonapeptide derived from the α1-chain of hemoglobin, is originally isolated from rat brain homogenates. Hemopressin is orally acti...
T13289	EHP-101	1818428-24-8	99.22%
T13289	EHP-101 (VCE-004.8) is a specific dual agonist of PPARγ and CB2 receptor with potent anti-inflammatory activity. EHP-101 attenuates adipogenesis and prevents die...
T21380	Pravadoline	92623-83-1	99.20%
T21380	Pravadoline (WIN48098-6) is a cannabinoid receptor agonist. Pravadoline inhibited the PGs synthesis in mouse brain and displayed antinociceptive activity in rode...
T2264	AM281	202463-68-1	99.2%
T2264	AM 281, a cannabinoid antagonist, reduces neurologic dysfunction and mortality rate after cecal ligation and puncture in rats.
T10694	CB1 inverse agonist 1	852315-00-5	99.12%
T10694	CB1 inverse agonist 1 (MRL-650) is an orally active and selective CB1 agonist. The IC50s for CB1 and CB2 are 7.5 nM and 4100 nM, respectively. CB1 inverse agonis...
T9114	β-Caryophyllene	87-44-5	99.11%
T9114	β-Caryophyllene ((-)-(E)-Caryophyllene) acts as an CB2 receptor agonist.
TN3575	(±)-Cannabichromene	20675-51-8	99.1%
TN3575	(±)-Cannabichromene is a major non-psychotropic phytocannabinoid that inhibits endocannabinoid inactivation and activates the transient receptor potential ankyri...
T67747	CB2R/FAAH modulator-3	2876918-67-9	99.02%
T67747	CB2R/FAAH modulator-3 (compound 27) is a modulator targeting at CB2R and FAAH. CB2R/FAAH modulator-3 acts as a CB2R agonist and FAAH inhibitor, the Ki values are...