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Cannabinoid Receptor

Cannabinoid receptors are of a class of cell membrane receptors in the G protein-coupled receptor superfamily. As is typical of G protein-coupled receptors, the cannabinoid receptors contain seven transmembrane spanning domains. Cannabinoid receptors are activated by three major groups of ligands: endocannabinoids, produced by the mammillary body;[citation needed] plant cannabinoids (such as cannabidiol, produced by the cannabis plant); and synthetic cannabinoids (such as HU-210). All of the endocannabinoids and phytocannabinoids (plant based cannabinoids) are lipophilic, such as fat soluble compounds.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T6755 AM1241 444912-48-5 98.72%
AM1241
AM-1241 is a selective cannabinoid CB2 receptor agonist with Ki of 3.4 nM, exhibits 82-fold selectivity over CB1 receptor.
T19094 2,3-Butanediol 513-85-9 98.64%
2,3-Butanediol
2,3-Butanediol is a butanediol derived from the bioconversion of natural resources which has great potential for diverse industries, including chemical, cosmetic...
T29930 AM-1235 335161-27-8 98.62%
AM-1235
AM-1235 is a potent and selective cannabinoid receptor CB1 agonist.
T7316 LY2828360 1231220-79-3 98.61%
LY2828360
LY2828360 is a cannabinoid (CB) receptor 2 agonist (Ki = 40.3 nM). It selectively activates CB2 over CB1 in a GTPγS binding assay (EC50s = 20.1 and >100,000 nM, ...
T41230 CB 65 913534-05-1 98.39%
CB 65
CB 65 is a high affinity and selective CB2 receptor agonist with Ki values of 3.3 and > 1000 nM for CB2 and CB1 receptors respectively.
T28468 PSNCBAM-1 877202-74-9 98.18%
PSNCBAM-1
PSNCBAM-1 (PSNCBAM 1) is a CB1 receptor negative allosteric modulator (EC50 = 0.1 μM) with hypophagic effects in vivo. PSNCBAM-1 can be used for obesity studies....
T37075 CB2R PAM 2244579-87-9 98.17%
CB2R PAM
CB2R PAM is an orally active cannabinoid type 2 receptor (CB2Rs) positive mutational modulator that enhances CP 55940 and 2-Arachidonylglycerol-stimulated [35S]G...
T22009 CB2 receptor agonist 2 1314230-75-5 98.07%
CB2 receptor agonist 2
CB2 receptor agonist 2 (ZINC72105556) is a potent and selective agonist for the CB2 (cannabinoid type 2) receptor, Ki = 8.5 nM. CB2 receptor agonist 2 has high a...
T1519L Rimonabant 168273-06-1 98%
Rimonabant
Rimonabant (SR141716) is an inverse agonist for the cannabinoid receptor CB1. It is an anorectic anti-obesity drug produced and marketed by Sanofi-Aventis. Its m...
T2635 Org 27569 868273-06-7 98%
Org 27569
Org 27569, an allosteric modulator of cannabinoid CB1 receptor, can induce a CB1 receptor state that is characterized by decreased inverse agonist affinity and e...
T5996 CB1-IN-1 1429239-98-4 98%
CB1-IN-1
CB1-IN-1 (DBPR211) is a peripherally restricted CB1R antagonist, for CB1R and CB2R with Ki of 0.3 nM and 21 nM,respectively.
T3699 Bay 59-3074 406205-74-1 98%
Bay 59-3074
Bay 59-3074 is a CB1/CB2 receptor partial agonist (Ki: 48.3/45.5 nM). In rat models of chronic neuropathic and inflammatory pain, it displays anti-hyperalgesic a...
T7375 A-836339 959746-77-1 98%
A-836339
A-836339 acts as a potent cannabinoid receptor full agonist which has a higher affinity for the peripheral CB2 receptor (Ki = 0.64 nM) over the central CB1 recep...
T3S0738 Yangonin 500-62-9 98%
yangonin
Yangonin (Y100550) is a novel CB receptor ligand, it exhibits affinity for the human recombinant CB receptor. Yangonin (Y100550) could be a valuable candidate fo...
T1915 AM251 183232-66-8 97.88%
AM251
AM251 is a effective CB1 receptor antagonist (IC50/Ki: 8 /7.49 nM) that displays 306-fold selectivity over CB2 receptors; also effective GPR55 agonist (EC50: 39 ...
T9114 β-Caryophyllene 87-44-5 97.31%
β-Caryophyllene
β-Caryophyllene ((-)-(E)-Caryophyllene) acts as an CB2 receptor agonist.
T14302 Olorinab 1268881-20-4 97.13%
Olorinab
Olorinab (APD 371) (APD 371) is a highly potent, selective and fully efficacious cannabinoid receptor type 2 (CB2) agonist. With an EC50 of 6.2 nM for hCB2.
TN5131 Tetrahydrocannabivarin 31262-37-0 96.30%
Tetrahydrocannabivarin
Tetrahydrocannabivarin (CRM) is a neutral cannabis receptor subtype (CB1) receptor antagonist, it can increases neural responding to rewarding and aversive stimu...
T24771 SCH-336 447459-51-0 95.01%
SCH-336
SCH-336 is a CB2 receptor agonist (Ki-1.8 nM, EC50-2 nM) with effective, selective, and oral activity. SCH-336 is also bioactive against CB1 receptor, and is 100...
T8511 TM38837 1253641-65-4 100%
TM38837
TM38837 is an antagonist of cannabinoid receptor type 1 (CB1), with potential for the treatment of obesity and type 2 diabetes.
AM1241
T6755
AM-1241 is a selective cannabinoid CB2 receptor agonist with Ki of 3.4 nM, exhibits 82-fold selectivity over CB1 receptor.
2,3-Butanediol
T19094
2,3-Butanediol is a butanediol derived from the bioconversion of natural resources which has great potential for diverse industries, including chemical, cosmetic...
AM-1235
T29930
AM-1235 is a potent and selective cannabinoid receptor CB1 agonist.
LY2828360
T7316
LY2828360 is a cannabinoid (CB) receptor 2 agonist (Ki = 40.3 nM). It selectively activates CB2 over CB1 in a GTPγS binding assay (EC50s = 20.1 and >100,000 nM, ...
CB 65
T41230
CB 65 is a high affinity and selective CB2 receptor agonist with Ki values of 3.3 and > 1000 nM for CB2 and CB1 receptors respectively.
PSNCBAM-1
T28468
PSNCBAM-1 (PSNCBAM 1) is a CB1 receptor negative allosteric modulator (EC50 = 0.1 μM) with hypophagic effects in vivo. PSNCBAM-1 can be used for obesity studies....
CB2R PAM
T37075
CB2R PAM is an orally active cannabinoid type 2 receptor (CB2Rs) positive mutational modulator that enhances CP 55940 and 2-Arachidonylglycerol-stimulated [35S]G...
CB2 receptor agonist 2
T22009
CB2 receptor agonist 2 (ZINC72105556) is a potent and selective agonist for the CB2 (cannabinoid type 2) receptor, Ki = 8.5 nM. CB2 receptor agonist 2 has high a...
Rimonabant
T1519L
Rimonabant (SR141716) is an inverse agonist for the cannabinoid receptor CB1. It is an anorectic anti-obesity drug produced and marketed by Sanofi-Aventis. Its m...
Org 27569
T2635
Org 27569, an allosteric modulator of cannabinoid CB1 receptor, can induce a CB1 receptor state that is characterized by decreased inverse agonist affinity and e...
CB1-IN-1
T5996
CB1-IN-1 (DBPR211) is a peripherally restricted CB1R antagonist, for CB1R and CB2R with Ki of 0.3 nM and 21 nM,respectively.
Bay 59-3074
T3699
Bay 59-3074 is a CB1/CB2 receptor partial agonist (Ki: 48.3/45.5 nM). In rat models of chronic neuropathic and inflammatory pain, it displays anti-hyperalgesic a...
A-836339
T7375
A-836339 acts as a potent cannabinoid receptor full agonist which has a higher affinity for the peripheral CB2 receptor (Ki = 0.64 nM) over the central CB1 recep...
yangonin
T3S0738
Yangonin (Y100550) is a novel CB receptor ligand, it exhibits affinity for the human recombinant CB receptor. Yangonin (Y100550) could be a valuable candidate fo...
AM251
T1915
AM251 is a effective CB1 receptor antagonist (IC50/Ki: 8 /7.49 nM) that displays 306-fold selectivity over CB2 receptors; also effective GPR55 agonist (EC50: 39 ...
β-Caryophyllene
T9114
β-Caryophyllene ((-)-(E)-Caryophyllene) acts as an CB2 receptor agonist.
Olorinab
T14302
Olorinab (APD 371) (APD 371) is a highly potent, selective and fully efficacious cannabinoid receptor type 2 (CB2) agonist. With an EC50 of 6.2 nM for hCB2.
Tetrahydrocannabivarin
TN5131
Tetrahydrocannabivarin (CRM) is a neutral cannabis receptor subtype (CB1) receptor antagonist, it can increases neural responding to rewarding and aversive stimu...
SCH-336
T24771
SCH-336 is a CB2 receptor agonist (Ki-1.8 nM, EC50-2 nM) with effective, selective, and oral activity. SCH-336 is also bioactive against CB1 receptor, and is 100...
TM38837
T8511
TM38837 is an antagonist of cannabinoid receptor type 1 (CB1), with potential for the treatment of obesity and type 2 diabetes.
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TargetMol